iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/SKP1	SKP1	12169662; 12795696; 16983093

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/SKP1	1.40e-32	112.5	122	169

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/SKP1

   S: 1    ksLLdltcktVadmikgktpeeiRktFnienDftpeEeakvReEnqWA 48
           k+LLdltc+tVadmikgktpeeiRktFni+nDftpeEe++vR+EnqWA
   Q: 122  KGLLDLTCQTVADMIKGKTPEEIRKTFNIKNDFTPEEEEEVRRENQWA 169
           89*********************************************9 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation.

Protein Sequence
(Fasta)

MSTVRKITLK SSDGENFEID EAVALESQTI KHMIEDDCTD NGIPLPNVTS KILSKVIEYC 60
KRHVEAAEKS ETTADAAAAT TTTTVASGSS DEDLKTWDSE FIKVDQGTLF DLILAANYLN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGAATTAA TTTTCAGGTG TTTTCCTTTG AAAGAAAAAA ACAGAGAAAA TGTTTTAAAA 60
TGAAAATTTA TAGGTAAAAA AAGTCAATTG GGAATCGTTA GATCTCACTG GTTCAATGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0927--Auxin signaling pathway
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0936--Ethylene signaling pathway
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016897--SKP1
IPR001232--SKP1-like
IPR011333--SKP1/BTB/POZ
IPR016072--Skp1_comp_dimer
IPR016073--Skp1_comp_POZ

Pfam

PF01466--Skp1
PF03931--Skp1_POZ

SMART

SM00512--Skp1

Gene Ontology

GO:0005634--C:nucleus
GO:0009734--P:auxin-activated signaling pathway
GO:0007059--P:chromosome segregation
GO:0009793--P:embryo development ending in seed dormancy
GO:0009873--P:ethylene-activated signaling pathway
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process

KEGG

ath:AT5G42190

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000773	Aegilops tauschii	77.25	8.00e-66	241.00
IUUC-Aml-002023	Ailuropoda melanoleuca	54.12	5.00e-39	152.00
IUUC-Apl-003393	Anas platyrhynchos	54.12	5.00e-39	152.00
IUUC-Aca-004709	Anolis carolinensis	54.12	5.00e-39	152.00
IUUC-Aly-006066	Arabidopsis lyrata	94.15	3.00e-73	266.00
IUUC-Ame-011025	Astyanax mexicanus	54.71	3.00e-39	153.00
IUUC-Bta-013519	Bos taurus	54.12	5.00e-39	152.00
IUUC-Bdi-014448	Brachypodium distachyon	72.51	2.00e-55	207.00
IUUC-Cja-019785	Callithrix jacchus	53.90	2.00e-37	147.00
IUUC-Cfa-020931	Canis familiaris	54.71	1.00e-38	151.00
IUUC-Cpo-022487	Cavia porcellus	55.03	2.00e-37	147.00
IUUC-Cre-022751	Chlamydomonas reinhardtii	65.66	3.00e-54	203.00
IUUC-Csa-023459	Chlorocebus sabaeus	53.53	2.00e-38	150.00
IUUC-Cin-025538	Ciona intestinalis	53.25	6.00e-38	149.00
IUUC-Csv-025865	Ciona savignyi	55.03	1.00e-39	154.00
IUUC-Dre-027756	Danio rerio	54.71	3.00e-39	153.00
IUUC-Dno-028924	Dasypus novemcinctus	54.12	5.00e-39	152.00
IUUC-Dor-030847	Dipodomys ordii	52.94	4.00e-35	139.00
IUUC-Eca-033320	Equus caballus	54.12	5.00e-39	152.00
IUUC-Eeu-034817	Erinaceus europaeus	73.17	1.00e-14	70.10
IUUC-Fca-035423	Felis catus	54.12	5.00e-39	152.00
IUUC-Fal-036956	Ficedula albicollis	54.12	5.00e-39	152.00
IUUC-Gmo-039178	Gadus morhua	54.71	5.00e-39	152.00
IUUC-Ggr-039831	Gaeumannomyces graminis	47.17	1.00e-35	141.00
IUUC-Gga-040238	Gallus gallus	54.12	5.00e-39	152.00
IUUC-Gac-041965	Gasterosteus aculeatus	54.71	5.00e-39	152.00
IUUC-Gma-042996	Glycine max	77.19	3.00e-61	226.00
IUUC-Ggo-045025	Gorilla gorilla	54.12	5.00e-39	152.00
IUUC-Hsa-046875	Homo sapiens	54.12	5.00e-39	152.00
IUUC-Hvu-047497	Hordeum vulgare	73.05	1.00e-55	207.00
IUUC-Lch-050522	Latimeria chalumnae	53.71	2.00e-41	160.00
IUUC-Lpe-050940	Leersia perrieri	75.60	2.00e-53	200.00
IUUC-Loc-052596	Lepisosteus oculatus	54.71	5.00e-39	152.00
IUUC-Laf-053847	Loxodonta africana	54.12	5.00e-39	152.00
IUUC-Mtr-058763	Medicago truncatula	77.19	3.00e-68	249.00
IUUC-Mga-059864	Meleagris gallopavo	54.12	5.00e-39	152.00
IUUC-Mdo-062509	Monodelphis domestica	54.12	5.00e-39	152.00
IUUC-Mmu-063694	Mus musculus	54.71	5.00e-39	152.00
IUUC-Mac-064626	Musa acuminata	76.79	2.00e-63	233.00
IUUC-Mpu-065990	Mustela putorius furo	54.12	5.00e-39	152.00
IUUC-Mlu-068168	Myotis lucifugus	54.12	5.00e-39	152.00
IUUC-Nle-070101	Nomascus leucogenys	54.12	5.00e-39	152.00
IUUC-Opr-070881	Ochotona princeps	54.12	5.00e-39	152.00
IUUC-Ont-071529	Oreochromis niloticus	54.71	5.00e-39	152.00
IUUC-Ocu-073780	Oryctolagus cuniculus	54.12	5.00e-39	152.00
IUUC-Oba-075368	Oryza barthii	74.55	4.00e-60	222.00
IUUC-Ogl-077679	Oryza glaberrima	74.55	5.00e-60	222.00
IUUC-Ogu-078125	Oryza glumaepatula	73.94	2.00e-60	223.00
IUUC-Oin-079779	Oryza indica	73.94	9.00e-60	221.00
IUUC-Olo-080526	Oryza longistaminata	71.82	2.00e-51	194.00
IUUC-Ome-081330	Oryza meridionalis	73.94	6.00e-60	222.00
IUUC-Oni-082143	Oryza nivara	73.94	9.00e-60	221.00
IUUC-Opu-083354	Oryza punctata	77.25	7.00e-57	212.00
IUUC-Oru-084246	Oryza rufipogon	77.84	1.00e-54	204.00
IUUC-Osa-085416	Oryza sativa	73.94	9.00e-60	221.00
IUUC-Ola-087270	Oryzias latipes	54.71	5.00e-39	152.00
IUUC-Olu-087667	Ostreococcus lucimarinus	63.03	9.00e-51	191.00
IUUC-Oga-089073	Otolemur garnettii	54.12	5.00e-39	152.00
IUUC-Oar-089762	Ovis aries	44.86	8.00e-34	135.00
IUUC-Ptr-090872	Pan troglodytes	52.66	3.00e-36	143.00
IUUC-Pan-091780	Papio anubis	54.12	5.00e-39	152.00
IUUC-Psi-093135	Pelodiscus sinensis	54.12	5.00e-39	152.00
IUUC-Pfo-097529	Poecilia formosa	54.71	5.00e-39	152.00
IUUC-Pab-098533	Pongo abelii	54.12	5.00e-39	152.00
IUUC-Pop-098957	Populus trichocarpa	77.19	4.00e-68	249.00
IUUC-Ppe-101503	Prunus persica	77.78	3.00e-69	252.00
IUUC-Pva-102901	Pteropus vampyrus	54.12	5.00e-39	152.00
IUUC-Rno-105499	Rattus norvegicus	54.71	5.00e-39	152.00
IUUC-Smo-109307	Selaginella moellendorffii	69.59	4.00e-58	216.00
IUUC-Sit-110435	Setaria italica	73.05	3.00e-57	213.00
IUUC-Sar-112973	Sorex araneus	49.41	5.00e-32	129.00
IUUC-Sbi-114358	Sorghum bicolor	75.15	1.00e-53	201.00
IUUC-Tgu-116474	Taeniopygia guttata	54.12	5.00e-39	152.00
IUUC-Tru-118429	Takifugu rubripes	55.29	5.00e-39	152.00
IUUC-Tsy-118896	Tarsius syrichta	54.12	5.00e-39	152.00
IUUC-Tni-119960	Tetraodon nigroviridis	55.29	5.00e-39	152.00
IUUC-Tae-123642	Triticum aestivum	77.84	5.00e-66	242.00
IUUC-Tur-126200	Triticum urartu	75.45	3.00e-63	233.00
IUUC-Tbe-127720	Tupaia belangeri	54.12	5.00e-39	152.00
IUUC-Ttr-129035	Tursiops truncatus	54.12	5.00e-39	152.00
IUUC-Vpa-130128	Vicugna pacos	54.71	6.00e-39	152.00
IUUC-Vvi-130994	Vitis vinifera	78.36	2.00e-68	251.00
IUUC-Xtr-132393	Xenopus tropicalis	54.12	5.00e-39	152.00
IUUC-Xma-133603	Xiphophorus maculatus	54.71	5.00e-39	152.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence