• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064188
UUCD1 version UUC-MuM-00957
Ensembl Protein ID ENSMUSP00000124293.1
UniProt Accession Q9DBU5; B2RRR0; Q8K565; RNF6_MOUSE
Genbank Protein ID AAK84435.1; BAB23526.1; BAE29425.1; BAE30953.1; EDL05801.1; EDL05802.1; AAI38546.1
Protein Name E3 ubiquitin-protein ligase RNF6; RING-type E3 ubiquitin transferase RNF6; RLIM-like protein
Genbank Nucleotide ID AY039004; AK004745; AK150269; AK152106; CH466614; CH466614; BC138545
Gene Name Rnf6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029634.15 ENSMUST00000161859.7 ENSMUSP00000124293.1
ENSMUSG00000029634.15 ENSMUST00000162219.1 ENSMUSP00000123708.1
ENSMUSG00000029634.15 ENSMUST00000161574.7 ENSMUSP00000123730.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 4.10e-06 28.3 614 655
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C +d+   + ++ lpC H fh +C+ +w       s + +CP+Cr
   Q: 614  CSVCISDYvaGNKLRQLPCLHEFHIHCIDRW------LSENCTCPVCR 655
           9*******884449*****************......**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
 E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Protein Sequence
(Fasta)
MDPSRSRSGG SGEESSFQEN ERRWQQERLH REEAYYQFIN ELSDEDYRLM RDHNLLGTPG 60
EITSEELQQR LERAKEQLAS QPGSDSAASD GDSESLRAHS DEDSLLRWLN TFRRTGNVTR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064188|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTCCTGAAG CCGCCACGGG CTCTGAGTGC CTTGACCCGA GCCCGCGACA GCCGGACCTG 60
CGCACAGCAG ATGCGGAACT CGGGCGCCGC GGCTCGGCTT CCGGGGAGCG CCGTTTCCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064188|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0043231--C:intracellular membrane-bounded organelle
GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0050681--F:androgen receptor binding
GO:0003677--F:DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030517--P:negative regulation of axon extension
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044314--P:protein K27-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:74132
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000525 Aegilops tauschii 57.78 2.00e-11 60.10
IUUC-Aml-001415 Ailuropoda melanoleuca 72.97 0.00e+00 823.00
IUUC-Apl-003834 Anas platyrhynchos 53.42 3.00e-156 545.00
IUUC-Aca-004373 Anolis carolinensis 46.61 3.00e-127 448.00
IUUC-Ame-011730 Astyanax mexicanus 60.35 8.00e-79 288.00
IUUC-Bta-012763 Bos taurus 65.55 0.00e+00 711.00
IUUC-Bol-015739 Brassica oleracea 42.11 1.00e-15 76.60
IUUC-Bra-017535 Brassica rapa 42.11 9.00e-16 76.60
IUUC-Cja-018980 Callithrix jacchus 73.07 0.00e+00 863.00
IUUC-Cfa-020416 Canis familiaris 72.42 0.00e+00 820.00
IUUC-Cpo-022086 Cavia porcellus 69.77 5.00e-138 484.00
IUUC-Csa-023246 Chlorocebus sabaeus 73.11 0.00e+00 863.00
IUUC-Cho-024749 Choloepus hoffmanni 69.61 0.00e+00 675.00
IUUC-Dre-028428 Danio rerio 59.79 5.00e-76 279.00
IUUC-Dno-029617 Dasypus novemcinctus 69.77 0.00e+00 784.00
IUUC-Dor-030800 Dipodomys ordii 69.79 4.00e-109 389.00
IUUC-Ete-032882 Echinops telfairi 66.74 2.00e-132 466.00
IUUC-Eca-033892 Equus caballus 72.55 0.00e+00 885.00
IUUC-Eeu-034563 Erinaceus europaeus 69.11 3.00e-89 322.00
IUUC-Fca-035765 Felis catus 72.97 0.00e+00 811.00
IUUC-Fal-036981 Ficedula albicollis 52.53 4.00e-151 528.00
IUUC-Gmo-039344 Gadus morhua 59.93 7.00e-86 311.00
IUUC-Gga-041114 Gallus gallus 58.82 1.00e-98 353.00
IUUC-Gac-042220 Gasterosteus aculeatus 58.68 5.00e-87 315.00
IUUC-Ggo-044902 Gorilla gorilla 72.63 0.00e+00 876.00
IUUC-Hsa-046548 Homo sapiens 73.34 0.00e+00 878.00
IUUC-Hvu-047764 Hordeum vulgare 57.78 4.00e-14 72.00
IUUC-Itr-048447 Ictidomys tridecemlineatus 72.85 0.00e+00 878.00
IUUC-Lch-050541 Latimeria chalumnae 53.02 2.00e-93 337.00
IUUC-Lpe-051371 Leersia perrieri 51.67 5.00e-14 71.60
IUUC-Laf-054296 Loxodonta africana 68.24 0.00e+00 778.00
IUUC-Mcc-054858 Macaca mulatta 72.75 0.00e+00 869.00
IUUC-Meu-056296 Macropus eugenii 58.22 3.00e-116 412.00
IUUC-Mtr-058518 Medicago truncatula 40.79 2.00e-14 72.40
IUUC-Mga-059307 Meleagris gallopavo 56.57 3.00e-93 336.00
IUUC-Mvi-060211 Microbotryum violaceum 36.62 3.00e-09 58.50
IUUC-Mmr-060699 Microcebus murinus 74.93 0.00e+00 913.00
IUUC-Mdo-062162 Monodelphis domestica 59.76 0.00e+00 633.00
IUUC-Mac-065654 Musa acuminata 40.23 4.00e-13 68.60
IUUC-Mpu-065891 Mustela putorius furo 72.23 0.00e+00 822.00
IUUC-Mlu-067177 Myotis lucifugus 71.75 0.00e+00 809.00
IUUC-Nle-069127 Nomascus leucogenys 73.20 0.00e+00 890.00
IUUC-Ont-072086 Oreochromis niloticus 59.53 1.00e-87 318.00
IUUC-Ocu-074281 Oryctolagus cuniculus 76.47 3.00e-53 200.00
IUUC-Oba-075544 Oryza barthii 43.66 1.00e-13 69.30
IUUC-Obr-076184 Oryza brachyantha 47.37 3.00e-13 69.70
IUUC-Ogl-077537 Oryza glaberrima 43.66 1.00e-13 69.30
IUUC-Oin-079430 Oryza indica 48.33 2.00e-13 69.30
IUUC-Olo-080739 Oryza longistaminata 48.33 4.00e-13 68.60
IUUC-Ome-081556 Oryza meridionalis 41.35 8.00e-15 73.60
IUUC-Opu-084125 Oryza punctata 50.00 4.00e-14 71.60
IUUC-Oru-085061 Oryza rufipogon 48.33 3.00e-13 68.90
IUUC-Osa-085384 Oryza sativa 43.75 9.00e-14 70.10
IUUC-Ola-087452 Oryzias latipes 58.94 8.00e-88 318.00
IUUC-Oga-088750 Otolemur garnettii 74.67 0.00e+00 889.00
IUUC-Oar-089523 Ovis aries 65.35 0.00e+00 691.00
IUUC-Ptr-091533 Pan troglodytes 73.34 0.00e+00 877.00
IUUC-Pan-092675 Papio anubis 73.20 0.00e+00 863.00
IUUC-Psi-093735 Pelodiscus sinensis 54.53 1.00e-166 580.00
IUUC-Pfo-096637 Poecilia formosa 57.24 2.00e-86 313.00
IUUC-Pab-098486 Pongo abelii 73.49 0.00e+00 899.00
IUUC-Pca-100143 Procavia capensis 69.61 2.00e-142 499.00
IUUC-Ppe-101930 Prunus persica 41.77 2.00e-14 72.00
IUUC-Pva-103151 Pteropus vampyrus 69.79 0.00e+00 810.00
IUUC-Rno-105745 Rattus norvegicus 84.67 0.00e+00 986.00
IUUC-Sha-106681 Sarcophilus harrisii 60.75 0.00e+00 647.00
IUUC-Sit-110544 Setaria italica 41.89 6.00e-14 72.00
IUUC-Sar-113229 Sorex araneus 69.90 4.00e-106 379.00
IUUC-Ssc-115345 Sus scrofa 55.80 3.00e-71 263.00
IUUC-Tgu-117477 Taeniopygia guttata 53.35 7.00e-146 511.00
IUUC-Tru-118302 Takifugu rubripes 59.08 4.00e-88 319.00
IUUC-Tsy-119338 Tarsius syrichta 61.99 0.00e+00 687.00
IUUC-Tni-119675 Tetraodon nigroviridis 55.52 1.00e-75 277.00
IUUC-Tae-123936 Triticum aestivum 37.29 3.00e-08 50.80
IUUC-Tur-125977 Triticum urartu 41.30 4.00e-15 75.10
IUUC-Tbe-127505 Tupaia belangeri 58.69 5.00e-78 285.00
IUUC-Ttr-128367 Tursiops truncatus 68.30 0.00e+00 689.00
IUUC-Vpa-130480 Vicugna pacos 70.03 1.00e-114 407.00
IUUC-Xma-133863 Xiphophorus maculatus 58.50 2.00e-87 317.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved