iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074190

Ensembl Protein ID

ENSOCUP00000008738.2

UniProt Accession

G1SYN6; G1SYN6_RABIT

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000010127.2	ENSOCUT00000010140.2	ENSOCUP00000008738.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.10e-25	89.6	1435	1488

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1435 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1488
           58********************************.*****99999*******876 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MAHSCRWRFP ARPGTQRVPA LLLPPGPSVG GGGLGALSSL LAVTAAVGRR RRRRAEIPGG 60
AVAASEPLVV RLAYCSISIV SKSKFIERAL LRVGPSFDAA LQVSAAIGNL RRFRAVFGES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCACA GCTGTCGGTG GCGCTTCCCC GCCCGACCCG GGACCACCGG GGGCGGCGGC 60
GGCGGGGGGC GCCGGGGCCT AGGGGGCGCC CCGGGGCAAC GCGTCCCGGC CCTGCTGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0008542--P:visual learning

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002274	Ailuropoda melanoleuca	92.38	0.00e+00	5941.00
IUUC-Atr-002455	Amborella trichopoda	46.84	1.00e-37	152.00
IUUC-Apl-003478	Anas platyrhynchos	78.85	0.00e+00	3922.00
IUUC-Aca-005086	Anolis carolinensis	64.56	0.00e+00	2874.00
IUUC-Aly-006448	Arabidopsis lyrata	46.84	6.00e-38	152.00
IUUC-Ath-006690	Arabidopsis thaliana	46.10	7.00e-36	145.00
IUUC-Bta-012974	Bos taurus	91.80	0.00e+00	5853.00
IUUC-Bol-016540	Brassica oleracea	46.75	2.00e-36	147.00
IUUC-Cja-019226	Callithrix jacchus	92.61	0.00e+00	5932.00
IUUC-Cfa-021049	Canis familiaris	91.90	0.00e+00	5845.00
IUUC-Cpo-021459	Cavia porcellus	91.40	0.00e+00	4232.00
IUUC-Csa-023434	Chlorocebus sabaeus	92.78	0.00e+00	5433.00
IUUC-Cho-024652	Choloepus hoffmanni	87.41	0.00e+00	3766.00
IUUC-Csv-026268	Ciona savignyi	37.11	1.00e-133	471.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	3.00e-12	67.40
IUUC-Dre-028180	Danio rerio	69.05	0.00e+00	1153.00
IUUC-Dno-029068	Dasypus novemcinctus	87.77	0.00e+00	5569.00
IUUC-Dor-030550	Dipodomys ordii	85.30	0.00e+00	5001.00
IUUC-Ete-032834	Echinops telfairi	82.56	0.00e+00	2681.00
IUUC-Eca-033615	Equus caballus	92.61	0.00e+00	5810.00
IUUC-Eeu-035136	Erinaceus europaeus	81.58	0.00e+00	1149.00
IUUC-Fca-036453	Felis catus	88.32	0.00e+00	2558.00
IUUC-Fal-037256	Ficedula albicollis	77.28	0.00e+00	4920.00
IUUC-Gmo-038641	Gadus morhua	67.54	0.00e+00	1092.00
IUUC-Gga-040828	Gallus gallus	77.82	0.00e+00	4866.00
IUUC-Gac-041452	Gasterosteus aculeatus	69.86	0.00e+00	1153.00
IUUC-Gma-043554	Glycine max	47.71	5.00e-37	149.00
IUUC-Ggo-045124	Gorilla gorilla	90.96	0.00e+00	5606.00
IUUC-Hsa-046143	Homo sapiens	93.10	0.00e+00	5855.00
IUUC-Itr-049024	Ictidomys tridecemlineatus	90.19	0.00e+00	5120.00
IUUC-Lch-049704	Latimeria chalumnae	65.60	0.00e+00	2956.00
IUUC-Loc-052181	Lepisosteus oculatus	79.04	0.00e+00	1309.00
IUUC-Laf-053946	Loxodonta africana	91.97	0.00e+00	5711.00
IUUC-Mcc-055508	Macaca mulatta	93.00	0.00e+00	5863.00
IUUC-Meu-056485	Macropus eugenii	80.00	0.00e+00	2976.00
IUUC-Mtr-058327	Medicago truncatula	40.89	8.00e-38	152.00
IUUC-Mga-059943	Meleagris gallopavo	75.55	0.00e+00	4528.00
IUUC-Mmr-061178	Microcebus murinus	91.18	0.00e+00	4339.00
IUUC-Mdo-063031	Monodelphis domestica	84.57	0.00e+00	3929.00
IUUC-Mmu-063650	Mus musculus	87.93	0.00e+00	4073.00
IUUC-Mpu-066495	Mustela putorius furo	92.58	0.00e+00	4010.00
IUUC-Mlu-068045	Myotis lucifugus	84.05	0.00e+00	5262.00
IUUC-Nle-069064	Nomascus leucogenys	93.00	0.00e+00	5893.00
IUUC-Opr-071043	Ochotona princeps	88.46	0.00e+00	4412.00
IUUC-Ont-072556	Oreochromis niloticus	69.84	0.00e+00	1123.00
IUUC-Oan-073324	Ornithorhynchus anatinus	75.99	0.00e+00	2127.00
IUUC-Oba-075647	Oryza barthii	48.08	4.00e-37	150.00
IUUC-Olo-080577	Oryza longistaminata	46.41	1.00e-34	141.00
IUUC-Ome-081214	Oryza meridionalis	48.08	4.00e-37	150.00
IUUC-Oni-083000	Oryza nivara	48.08	4.00e-37	150.00
IUUC-Opu-083842	Oryza punctata	48.08	4.00e-37	150.00
IUUC-Oru-084361	Oryza rufipogon	48.08	4.00e-37	150.00
IUUC-Ola-087176	Oryzias latipes	64.43	0.00e+00	1127.00
IUUC-Oga-088208	Otolemur garnettii	91.74	0.00e+00	5779.00
IUUC-Oar-090152	Ovis aries	91.62	0.00e+00	5892.00
IUUC-Ptr-091127	Pan troglodytes	92.99	0.00e+00	5822.00
IUUC-Pan-092679	Papio anubis	93.12	0.00e+00	4706.00
IUUC-Psi-094059	Pelodiscus sinensis	78.24	0.00e+00	4903.00
IUUC-Pma-094258	Petromyzon marinus	59.66	0.00e+00	675.00
IUUC-Pfo-096536	Poecilia formosa	72.13	0.00e+00	1112.00
IUUC-Pab-098262	Pongo abelii	93.07	0.00e+00	5922.00
IUUC-Pca-100358	Procavia capensis	87.46	0.00e+00	5371.00
IUUC-Pva-102522	Pteropus vampyrus	86.63	0.00e+00	4627.00
IUUC-Rno-105200	Rattus norvegicus	88.13	0.00e+00	3989.00
IUUC-Sha-107174	Sarcophilus harrisii	84.16	0.00e+00	5265.00
IUUC-Smo-109164	Selaginella moellendorffii	50.65	2.00e-39	157.00
IUUC-Sly-111158	Solanum lycopersicum	37.50	9.00e-35	142.00
IUUC-Stu-112529	Solanum tuberosum	47.06	3.00e-37	150.00
IUUC-Sar-113503	Sorex araneus	81.37	0.00e+00	3014.00
IUUC-Sbi-114254	Sorghum bicolor	26.28	8.00e-10	59.30
IUUC-Tgu-117047	Taeniopygia guttata	77.54	0.00e+00	4866.00
IUUC-Tru-118328	Takifugu rubripes	65.57	0.00e+00	1148.00
IUUC-Tsy-118953	Tarsius syrichta	85.67	0.00e+00	2966.00
IUUC-Tni-120837	Tetraodon nigroviridis	65.05	0.00e+00	1131.00
IUUC-Tbe-127950	Tupaia belangeri	86.16	0.00e+00	2783.00
IUUC-Ttr-128643	Tursiops truncatus	90.26	0.00e+00	5646.00
IUUC-Vpa-130660	Vicugna pacos	88.23	0.00e+00	1996.00
IUUC-Vvi-131476	Vitis vinifera	45.56	5.00e-38	153.00
IUUC-Xtr-132869	Xenopus tropicalis	60.14	0.00e+00	3658.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence