iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003673

Ensembl Protein ID

ENSAPLP00000004092.1

UniProt Accession

R0JTJ0; R0JTJ0_ANAPL

Genbank Protein ID

EOB00771.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADON01077953

Gene Name

USP44; Anapl_11150

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000004576.1	ENSAPLT00000004700.1	ENSAPLP00000004092.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.10e-98	327.8	275	683

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp............................................ 42
           tGl+NlgNtCYmNS+LQ+Ls++  +re++l+   ++++      +                                            
   Q: 275  TGLRNLGNTCYMNSILQVLSHLLIFRECFLKldlNQTQ------Ellataasgktrssskhpsvtastlqvsenqekgkgsssvrrssl 357
           7******************************5552222......22334557888888889999999999**9999************* PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el  
   Q: 358  ssglsggasksrnmeliqprepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQQEL-- 444
           ******999999999999999999999************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdc 190
                  e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +         l+++
   Q: 445  -------ETTGTRYPALIPASQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYHCNGKemasqypcLLTEM 526
           .......77888888999999***********************************************99999877999999*9***** PP
   S: 191  Lesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctsp 268
           L++ft++e leg+  y c++c+ k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v+f ++L+++p+c+++
   Q: 527  LAKFTETEALEGKI-YACDQCNTKRRkfsskpvilteAQKQLMVCRLPQVLRLHLKRFRWSGR-NHREKIGVHVNFDQMLNMEPYCCRE 613
           ***********965.*******999999999999999***********************997.8889********************7 PP
   S: 269  eekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           + k     + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + +++eev++   ++aY+lfY +
   Q: 614  SLKTLLpdCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLNMCTMEEVCK---AQAYILFYSQ 683
           76654366****************************9999********************...********87 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

VLTMDKCKHI GRLRLAQDHS ILNPQKWHCV DCNTTESVWA CLSCSHVACG RYIEEHALKH 60
FQENGHPVAL EVNELYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKSQNY ECTTRSGRTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTAACGA TGGATAAGTG TAAGCACATA GGACGTCTGC GACTGGCCCA GGATCACTCC 60
ATCCTGAATC CTCAGAAATG GCACTGCGTG GACTGCAACA CCACCGAATC CGTGTGGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	76.58	0.00e+00	1068.00
IUUC-Aca-004434	Anolis carolinensis	83.80	0.00e+00	1143.00
IUUC-Ame-010986	Astyanax mexicanus	68.84	0.00e+00	924.00
IUUC-Bta-012774	Bos taurus	75.60	0.00e+00	1072.00
IUUC-Cja-019619	Callithrix jacchus	74.93	0.00e+00	1054.00
IUUC-Cfa-020957	Canis familiaris	75.60	0.00e+00	1067.00
IUUC-Csa-023177	Chlorocebus sabaeus	75.35	0.00e+00	1061.00
IUUC-Cho-024877	Choloepus hoffmanni	72.61	0.00e+00	661.00
IUUC-Dre-027878	Danio rerio	70.20	0.00e+00	894.00
IUUC-Dno-029832	Dasypus novemcinctus	75.46	0.00e+00	1071.00
IUUC-Ete-032627	Echinops telfairi	73.43	0.00e+00	1031.00
IUUC-Eca-033863	Equus caballus	73.10	0.00e+00	1023.00
IUUC-Eeu-035225	Erinaceus europaeus	73.13	0.00e+00	991.00
IUUC-Fca-036288	Felis catus	75.46	0.00e+00	1054.00
IUUC-Fal-037207	Ficedula albicollis	91.33	0.00e+00	1253.00
IUUC-Gga-040457	Gallus gallus	95.10	0.00e+00	1256.00
IUUC-Ggo-044926	Gorilla gorilla	75.35	0.00e+00	1056.00
IUUC-Hsa-046079	Homo sapiens	75.35	0.00e+00	1055.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	76.45	0.00e+00	1053.00
IUUC-Lch-050260	Latimeria chalumnae	75.68	0.00e+00	1007.00
IUUC-Loc-051981	Lepisosteus oculatus	81.61	0.00e+00	710.00
IUUC-Laf-054491	Loxodonta africana	75.76	0.00e+00	1033.00
IUUC-Mcc-055694	Macaca mulatta	75.63	0.00e+00	1062.00
IUUC-Mga-059523	Meleagris gallopavo	94.98	0.00e+00	1278.00
IUUC-Mmr-060885	Microcebus murinus	76.39	0.00e+00	1083.00
IUUC-Mdo-063018	Monodelphis domestica	84.95	0.00e+00	1157.00
IUUC-Mmu-064012	Mus musculus	69.86	0.00e+00	930.00
IUUC-Mpu-066207	Mustela putorius furo	75.60	0.00e+00	1074.00
IUUC-Mlu-066929	Myotis lucifugus	74.26	0.00e+00	1007.00
IUUC-Nle-069313	Nomascus leucogenys	66.76	0.00e+00	894.00
IUUC-Opr-070375	Ochotona princeps	71.72	0.00e+00	970.00
IUUC-Ont-071637	Oreochromis niloticus	70.34	0.00e+00	930.00
IUUC-Oan-073030	Ornithorhynchus anatinus	85.03	0.00e+00	932.00
IUUC-Ocu-074836	Oryctolagus cuniculus	73.70	0.00e+00	1014.00
IUUC-Oga-088367	Otolemur garnettii	76.44	0.00e+00	1062.00
IUUC-Oar-089953	Ovis aries	76.16	0.00e+00	1080.00
IUUC-Ptr-090980	Pan troglodytes	75.35	0.00e+00	1056.00
IUUC-Pan-092748	Papio anubis	76.02	0.00e+00	1072.00
IUUC-Psi-094078	Pelodiscus sinensis	90.29	0.00e+00	982.00
IUUC-Pab-098514	Pongo abelii	76.90	0.00e+00	1066.00
IUUC-Pva-102984	Pteropus vampyrus	76.85	0.00e+00	1068.00
IUUC-Rno-106019	Rattus norvegicus	69.77	0.00e+00	964.00
IUUC-Sha-106965	Sarcophilus harrisii	84.58	0.00e+00	1149.00
IUUC-Ssc-115299	Sus scrofa	75.60	0.00e+00	1073.00
IUUC-Tgu-117160	Taeniopygia guttata	87.17	0.00e+00	1171.00
IUUC-Tru-118156	Takifugu rubripes	68.09	0.00e+00	897.00
IUUC-Tni-119733	Tetraodon nigroviridis	65.52	0.00e+00	894.00
IUUC-Tbe-128084	Tupaia belangeri	71.57	0.00e+00	1000.00
IUUC-Ttr-128928	Tursiops truncatus	76.72	0.00e+00	1089.00
IUUC-Vpa-130706	Vicugna pacos	76.72	0.00e+00	1080.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence