iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012831

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase HACE1

Genbank Nucleotide ID

DAAA02026050

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000001533.5	ENSBTAT00000002010.5	ENSBTAP00000002010.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-117	392.6	570	899

Active Site

Position(s)	Description	Evidence
870	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al +++l+++ 
   Q: 570  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALNHRQLVNIY 655
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 656  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 741
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e+++ eer  +LqFvT
   Q: 742  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITPEERVLLLQFVT 830
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 831  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 899
           ******************8888888868888********************************986555 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MALAGNTQAS HHLPLDILAD NETAVYTLMP MVMADQHRSV SELLSNSKFD VNYAFGRVKR 60
SLLHIAANCG SVECLVLLLK KGANPNYQDI SGCTPLHLAA RNGQKKCMSK LLEYSADVNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCATTGG CAGGGAACAC CCAGGCCAGC CACCATCTGC CCTTGGATAT CCTGGCAGGT 60
GAGATTCTCT TATGCCTCCT GGGCCAGCCA ATATATAACA CCAACATACA TGTGCTCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	98.43	0.00e+00	1831.00
IUUC-Apl-003400	Anas platyrhynchos	88.19	0.00e+00	1155.00
IUUC-Aca-005375	Anolis carolinensis	90.56	0.00e+00	1687.00
IUUC-Ame-011847	Astyanax mexicanus	84.83	0.00e+00	1601.00
IUUC-Cja-019160	Callithrix jacchus	98.09	0.00e+00	1825.00
IUUC-Cfa-020346	Canis familiaris	99.21	0.00e+00	1840.00
IUUC-Cpo-021766	Cavia porcellus	96.63	0.00e+00	1803.00
IUUC-Csa-023768	Chlorocebus sabaeus	97.75	0.00e+00	1823.00
IUUC-Cho-024688	Choloepus hoffmanni	94.02	0.00e+00	1177.00
IUUC-Cin-025417	Ciona intestinalis	50.73	1.00e-139	490.00
IUUC-Csv-025993	Ciona savignyi	43.24	0.00e+00	735.00
IUUC-Dre-027819	Danio rerio	85.62	0.00e+00	1588.00
IUUC-Dno-029027	Dasypus novemcinctus	96.87	0.00e+00	1795.00
IUUC-Dor-030327	Dipodomys ordii	90.26	0.00e+00	1631.00
IUUC-Ete-032966	Echinops telfairi	89.55	0.00e+00	1650.00
IUUC-Eca-034339	Equus caballus	98.98	0.00e+00	1831.00
IUUC-Eeu-034544	Erinaceus europaeus	69.01	0.00e+00	646.00
IUUC-Fca-035617	Felis catus	99.23	0.00e+00	1351.00
IUUC-Fal-036687	Ficedula albicollis	91.06	0.00e+00	1713.00
IUUC-Gmo-039508	Gadus morhua	88.15	0.00e+00	832.00
IUUC-Gga-040845	Gallus gallus	91.38	0.00e+00	1735.00
IUUC-Gac-041894	Gasterosteus aculeatus	85.20	0.00e+00	1573.00
IUUC-Ggo-044465	Gorilla gorilla	93.95	0.00e+00	1744.00
IUUC-Hsa-045731	Homo sapiens	97.98	0.00e+00	1827.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	98.09	0.00e+00	1820.00
IUUC-Lch-050436	Latimeria chalumnae	88.94	0.00e+00	1645.00
IUUC-Loc-052287	Lepisosteus oculatus	85.14	0.00e+00	1620.00
IUUC-Laf-053846	Loxodonta africana	97.98	0.00e+00	1819.00
IUUC-Mcc-055845	Macaca mulatta	97.86	0.00e+00	1826.00
IUUC-Meu-056060	Macropus eugenii	97.69	0.00e+00	703.00
IUUC-Mga-059935	Meleagris gallopavo	94.58	0.00e+00	1745.00
IUUC-Mmr-060960	Microcebus murinus	98.54	0.00e+00	1833.00
IUUC-Mdo-061851	Monodelphis domestica	92.62	0.00e+00	1767.00
IUUC-Mmu-063657	Mus musculus	96.29	0.00e+00	1800.00
IUUC-Mpu-066161	Mustela putorius furo	99.50	0.00e+00	832.00
IUUC-Mlu-067354	Myotis lucifugus	98.42	0.00e+00	1797.00
IUUC-Nle-069112	Nomascus leucogenys	97.86	0.00e+00	1824.00
IUUC-Opr-070686	Ochotona princeps	89.07	0.00e+00	810.00
IUUC-Ont-072398	Oreochromis niloticus	84.70	0.00e+00	1570.00
IUUC-Oan-073194	Ornithorhynchus anatinus	94.98	0.00e+00	1734.00
IUUC-Ocu-074397	Oryctolagus cuniculus	85.35	0.00e+00	1523.00
IUUC-Ola-086777	Oryzias latipes	80.54	0.00e+00	1520.00
IUUC-Oga-088684	Otolemur garnettii	98.20	0.00e+00	1825.00
IUUC-Oar-089428	Ovis aries	98.97	0.00e+00	1804.00
IUUC-Ptr-090529	Pan troglodytes	97.86	0.00e+00	1824.00
IUUC-Pan-091702	Papio anubis	97.75	0.00e+00	1825.00
IUUC-Psi-093969	Pelodiscus sinensis	91.19	0.00e+00	1709.00
IUUC-Pfo-097364	Poecilia formosa	86.18	0.00e+00	1594.00
IUUC-Pab-098574	Pongo abelii	97.98	0.00e+00	1827.00
IUUC-Pca-100525	Procavia capensis	70.02	5.00e-168	585.00
IUUC-Pva-102365	Pteropus vampyrus	87.10	0.00e+00	1563.00
IUUC-Rno-105153	Rattus norvegicus	96.18	0.00e+00	1801.00
IUUC-Sha-107319	Sarcophilus harrisii	92.62	0.00e+00	1763.00
IUUC-Sar-113449	Sorex araneus	82.37	8.00e-180	624.00
IUUC-Ssc-115865	Sus scrofa	99.21	0.00e+00	1835.00
IUUC-Tgu-117225	Taeniopygia guttata	91.06	0.00e+00	1728.00
IUUC-Tru-118026	Takifugu rubripes	81.69	0.00e+00	1551.00
IUUC-Tsy-119407	Tarsius syrichta	84.81	0.00e+00	1529.00
IUUC-Tni-120234	Tetraodon nigroviridis	84.30	0.00e+00	1258.00
IUUC-Tur-126774	Triticum urartu	29.17	5.00e-46	179.00
IUUC-Tbe-127708	Tupaia belangeri	88.66	0.00e+00	881.00
IUUC-Ttr-128667	Tursiops truncatus	98.98	0.00e+00	1833.00
IUUC-Vpa-130200	Vicugna pacos	99.09	0.00e+00	1825.00
IUUC-Xtr-132176	Xenopus tropicalis	87.27	0.00e+00	1655.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence