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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018191
UUCD1 version UUC-CaE-00036
Ensembl Protein ID F35G12.9
UniProt Accession Q20052; APC11_CAEEL
Genbank Protein ID CAA86328.1
Protein Name Anaphase-promoting complex subunit 11
Genbank Nucleotide ID Z46242
Gene Name apc-11; F35G12.9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000145 F35G12.9 F35G12.9
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 15530417
Classification
Family E-value Score Start End
E3 activity/RING/RING 7.70e-08 33.0 72 128
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...........kdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+ +f           +d+plvl+ C H+fh++C+ kw       +++++CPlCr
   Q: 72   CGICRMEFesacnmckfpgDDCPLVLGiCRHAFHRHCIDKW-IAAPTNQPRAQCPLCR 128
           999*777788888888899555888888*************.6666899********8 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581). Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis (PubMed:11861581). In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity (PubMed:15466891).
 Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581). Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis (PubMed:11861581). In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity (PubMed:15466891).
Protein Sequence
(Fasta)
MEQQIQMDEQ ENDESQGNDD QQNMSMSSSE LHTMQDDHPG ILLKTNTRMS ITVKKLHVCG 60
EWKWLQGGED TCGICRMEFE SACNMCKFPG DDCPLVLGIC RHAFHRHCID KWIAAPTNQP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018191|E3,RING|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
AGAAATGGAG CAACAAATTC AAATGGACGA ACAGGAAAAT GATGAATCAC AGGGAAACGA 60
TGATCAACAA AATATGTCGA TGAGCAGTTC TGAACTTCAT ACTGTAAGAC ATATAAGAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018191|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR024991--Apc11
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF12861--zf-ANAPC11
SMART

SM00184--RING
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0045132--P:meiotic chromosome segregation
GO:0007067--P:mitotic nuclear division
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG cel:CELE_F35G12.9
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002323 Ailuropoda melanoleuca 48.28 5.00e-19 84.00
IUUC-Aly-006393 Arabidopsis lyrata 48.24 1.00e-20 89.70
IUUC-Ath-006698 Arabidopsis thaliana 48.24 1.00e-20 89.70
IUUC-Ago-007824 Ashbya gossypii 46.27 7.00e-16 75.10
IUUC-Acl-008180 Aspergillus clavatus 43.90 1.00e-19 86.70
IUUC-Afl-008622 Aspergillus flavus 45.68 9.00e-20 87.00
IUUC-Afu-008844 Aspergillus fumigatus 45.68 4.00e-20 87.80
IUUC-Ani-009260 Aspergillus nidulans 43.90 1.00e-19 86.30
IUUC-Ang-009794 Aspergillus niger 40.45 1.00e-20 93.20
IUUC-Ame-011274 Astyanax mexicanus 47.13 7.00e-18 80.10
IUUC-Bgr-012017 Blumeria graminis 38.27 1.00e-13 66.20
IUUC-Bta-012644 Bos taurus 48.28 6.00e-19 83.60
IUUC-Bci-013779 Botrytis cinerea 41.86 3.00e-18 81.60
IUUC-Bdi-014975 Brachypodium distachyon 50.60 9.00e-22 93.20
IUUC-Bol-016184 Brassica oleracea 49.38 2.00e-20 88.60
IUUC-Bra-016983 Brassica rapa 43.30 7.00e-22 94.70
IUUC-Cja-019909 Callithrix jacchus 48.28 6.00e-19 83.60
IUUC-Cfa-020306 Canis familiaris 48.28 5.00e-19 84.00
IUUC-Cpo-021773 Cavia porcellus 48.28 5.00e-19 84.00
IUUC-Cre-022961 Chlamydomonas reinhardtii 46.99 4.00e-19 84.30
IUUC-Csa-024274 Chlorocebus sabaeus 48.28 6.00e-19 83.60
IUUC-Cgl-026398 Colletotrichum gloeosporioides 41.98 9.00e-18 80.10
IUUC-Cne-027036 Cryptococcus neoformans 52.46 2.00e-16 75.90
IUUC-Cme-027263 Cyanidioschyzon merolae 51.81 2.00e-22 95.10
IUUC-Dre-027617 Danio rerio 47.13 5.00e-18 80.50
IUUC-Dse-031304 Dothistroma septosporum 50.60 3.00e-22 94.70
IUUC-Dme-031897 Drosophila melanogaster 51.16 1.00e-21 92.40
IUUC-Fca-036297 Felis catus 47.87 1.00e-20 90.10
IUUC-Fal-037228 Ficedula albicollis 48.28 1.00e-19 86.30
IUUC-Fox-037929 Fusarium oxysporum 45.61 5.00e-13 63.90
IUUC-Fso-038194 Fusarium solani 44.44 2.00e-18 81.60
IUUC-Gmo-039638 Gadus morhua 57.14 9.00e-11 56.60
IUUC-Gga-040897 Gallus gallus 47.13 7.00e-19 83.20
IUUC-Gac-041644 Gasterosteus aculeatus 57.14 9.00e-11 56.60
IUUC-Gma-043111 Glycine max 48.84 3.00e-22 95.50
IUUC-Hsa-046268 Homo sapiens 48.28 6.00e-19 83.60
IUUC-Hvu-047305 Hordeum vulgare 48.19 4.00e-22 94.40
IUUC-Itr-048453 Ictidomys tridecemlineatus 48.28 5.00e-19 84.00
IUUC-Kpa-049388 Komagataella pastoris 34.55 1.00e-16 77.40
IUUC-Lch-049838 Latimeria chalumnae 47.13 2.00e-20 88.60
IUUC-Lpe-050878 Leersia perrieri 53.12 9.00e-17 76.60
IUUC-Lma-053166 Leptosphaeria maculans 45.68 6.00e-21 90.90
IUUC-Laf-054221 Loxodonta africana 48.28 5.00e-19 84.00
IUUC-Mor-056930 Magnaporthe oryzae 43.21 3.00e-18 81.60
IUUC-Mtr-058104 Medicago truncatula 49.41 9.00e-21 89.70
IUUC-Mla-059079 Melampsora laricipopulina 33.63 5.00e-15 71.60
IUUC-Mvi-060446 Microbotryum violaceum 47.69 3.00e-14 69.70
IUUC-Mmu-064301 Mus musculus 48.28 5.00e-19 84.00
IUUC-Mac-064936 Musa acuminata 51.81 1.00e-22 96.70
IUUC-Mpu-066041 Mustela putorius furo 48.28 5.00e-19 84.00
IUUC-Mlu-067360 Myotis lucifugus 48.28 6.00e-19 83.60
IUUC-Ncr-068931 Neurospora crassa 43.21 2.00e-18 82.40
IUUC-Ont-072502 Oreochromis niloticus 48.24 1.00e-18 82.80
IUUC-Ocu-074751 Oryctolagus cuniculus 41.38 3.00e-14 68.20
IUUC-Oba-075026 Oryza barthii 49.41 6.00e-22 93.60
IUUC-Obr-076888 Oryza brachyantha 48.28 2.00e-22 96.30
IUUC-Ogl-077825 Oryza glaberrima 49.40 3.00e-21 91.30
IUUC-Ogu-078433 Oryza glumaepatula 46.24 1.00e-22 98.20
IUUC-Oin-079835 Oryza indica 49.40 3.00e-21 91.30
IUUC-Ome-081297 Oryza meridionalis 52.94 2.00e-18 84.00
IUUC-Oni-082739 Oryza nivara 46.24 4.00e-23 99.00
IUUC-Opu-083502 Oryza punctata 53.12 3.00e-17 78.20
IUUC-Oru-084838 Oryza rufipogon 46.24 7.00e-23 97.80
IUUC-Osa-086037 Oryza sativa 49.40 3.00e-21 91.30
IUUC-Ola-087572 Oryzias latipes 48.28 2.00e-18 81.60
IUUC-Olu-087765 Ostreococcus lucimarinus 45.35 3.00e-17 78.20
IUUC-Oga-088853 Otolemur garnettii 48.28 4.00e-19 84.30
IUUC-Oar-089687 Ovis aries 48.28 5.00e-19 84.00
IUUC-Ptr-091674 Pan troglodytes 48.28 6.00e-19 83.60
IUUC-Psi-093124 Pelodiscus sinensis 47.13 3.00e-19 84.70
IUUC-Pno-094852 Phaeosphaeria nodorum 45.68 5.00e-21 91.30
IUUC-Ppa-095866 Physcomitrella patens 51.90 5.00e-21 90.50
IUUC-Pfo-096410 Poecilia formosa 47.13 3.00e-18 81.60
IUUC-Pop-099204 Populus trichocarpa 45.45 8.00e-22 93.60
IUUC-Ppe-101903 Prunus persica 49.40 8.00e-22 93.20
IUUC-Pte-104160 Pyrenophora teres 45.68 5.00e-20 87.80
IUUC-Rno-104979 Rattus norvegicus 48.28 5.00e-19 84.00
IUUC-Sce-106149 Saccharomyces cerevisiae 37.25 9.00e-19 84.70
IUUC-Sja-107930 Schizosaccharomyces japonicus 43.68 1.00e-20 89.40
IUUC-Spo-108296 Schizosaccharomyces pombe 40.23 5.00e-19 84.00
IUUC-Ssl-108464 Sclerotinia sclerotiorum 33.33 7.00e-11 56.60
IUUC-Smo-109289 Selaginella moellendorffii 51.95 1.00e-20 89.00
IUUC-Sit-109777 Setaria italica 48.19 2.00e-21 91.70
IUUC-Stu-112287 Solanum tuberosum 49.38 7.00e-20 87.40
IUUC-Sbi-113803 Sorghum bicolor 48.19 2.00e-21 91.70
IUUC-Sre-115018 Sporisorium reilianum 43.18 3.00e-16 75.10
IUUC-Ssc-116403 Sus scrofa 48.78 1.00e-17 79.30
IUUC-Tgu-117375 Taeniopygia guttata 48.28 1.00e-19 86.30
IUUC-Tru-118064 Takifugu rubripes 48.19 1.00e-17 79.00
IUUC-Tni-120387 Tetraodon nigroviridis 47.13 2.00e-18 82.00
IUUC-Tca-121186 Theobroma cacao 54.39 2.00e-15 72.00
IUUC-Tre-122153 Trichoderma reesei 44.44 1.00e-18 82.80
IUUC-Tvi-122412 Trichoderma virens 44.44 1.00e-18 82.80
IUUC-Tae-125184 Triticum aestivum 48.19 2.00e-21 91.70
IUUC-Tur-126516 Triticum urartu 47.06 4.00e-21 90.90
IUUC-Tme-127121 Tuber melanosporum 44.19 3.00e-21 91.30
IUUC-Uma-129529 Ustilago maydis 42.86 4.00e-15 71.60
IUUC-Vvi-131191 Vitis vinifera 44.44 3.00e-21 92.80
IUUC-Xma-133275 Xiphophorus maculatus 47.13 4.00e-18 80.90
IUUC-Yli-134369 Yarrowia lipolytica 43.21 1.00e-19 87.00
IUUC-Zma-134869 Zea mays 48.19 1.00e-21 92.80
Created Date 25-Jun-2017

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