iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000018743.3	ENSMMUT00000026357.3	ENSMMUP00000024673.3
ENSMMUG00000018743.3	ENSMMUT00000059748.1	ENSMMUP00000044031.1
ENSMMUG00000018743.3	ENSMMUT00000026355.3	ENSMMUP00000024671.3
ENSMMUG00000018743.3	ENSMMUT00000026359.3	ENSMMUP00000024675.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-63	216.0	169	655

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 169  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 256
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l
   Q: 257  DSQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 325
           **********************33..................123456788999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 326  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 403
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 404  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidassppsgsipsqtlpstte 492
           ****8888888888888888888888888888888888888888888888888887777777777777777777777777777766555 PP
   S: 268  .........peekqke......................................................................... 274
                    p     +                                                                         
   Q: 493  qqgapsselP-----Stspssvaavssrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrt 576
           5555555550.....05555555666666666666666666666666666666666666677777777777777777777888888888 PP
   S: 275  ...........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                      ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 577  ielmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRESrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 655
           88888888888**************************966556***************99997779************6 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDTQILQQAL KDSNGNLELA VAFLTAKNAK 60
TPQQEEATYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL AESNRAFRET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAGGACTC ACAGAAGGAG GAGGACAGCG CCATTCCGGC GCGGCCGCTC CCTCCGTCCC 60
CTCTCTCCCT TCCCTAAAGC GGCCCGCGAG CCGCGAGCGC GAAGCCGCCA GCTAAGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	93.68	0.00e+00	2044.00
IUUC-Apl-004030	Anas platyrhynchos	83.02	0.00e+00	1870.00
IUUC-Aca-004753	Anolis carolinensis	64.78	0.00e+00	1045.00
IUUC-Ame-010624	Astyanax mexicanus	70.94	0.00e+00	1134.00
IUUC-Bta-013166	Bos taurus	96.78	0.00e+00	1442.00
IUUC-Cel-018346	Caenorhabditis elegans	27.59	1.00e-27	119.00
IUUC-Cja-019150	Callithrix jacchus	99.20	0.00e+00	2160.00
IUUC-Cfa-020649	Canis familiaris	96.80	0.00e+00	2135.00
IUUC-Cpo-021807	Cavia porcellus	93.07	0.00e+00	2098.00
IUUC-Csa-023388	Chlorocebus sabaeus	99.91	0.00e+00	2171.00
IUUC-Cho-024343	Choloepus hoffmanni	96.38	3.00e-152	532.00
IUUC-Cin-025302	Ciona intestinalis	37.33	8.00e-95	341.00
IUUC-Csv-025911	Ciona savignyi	34.12	1.00e-125	444.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	53.19	6.00e-10	60.50
IUUC-Dre-028016	Danio rerio	75.49	0.00e+00	1690.00
IUUC-Dno-029495	Dasypus novemcinctus	94.36	0.00e+00	2108.00
IUUC-Dor-030948	Dipodomys ordii	82.02	0.00e+00	1474.00
IUUC-Fca-035876	Felis catus	96.86	0.00e+00	1437.00
IUUC-Fal-036762	Ficedula albicollis	84.26	0.00e+00	1103.00
IUUC-Gmo-039490	Gadus morhua	71.68	0.00e+00	1575.00
IUUC-Gga-040817	Gallus gallus	84.77	0.00e+00	1936.00
IUUC-Gac-042473	Gasterosteus aculeatus	71.74	0.00e+00	1603.00
IUUC-Ggo-044939	Gorilla gorilla	94.49	0.00e+00	2026.00
IUUC-Hsa-046204	Homo sapiens	99.49	0.00e+00	1472.00
IUUC-Kpa-049349	Komagataella pastoris	28.27	3.00e-10	61.60
IUUC-Lch-049572	Latimeria chalumnae	79.21	0.00e+00	1761.00
IUUC-Loc-052070	Lepisosteus oculatus	78.45	0.00e+00	1745.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	5.00e-12	67.40
IUUC-Laf-054426	Loxodonta africana	96.96	0.00e+00	1300.00
IUUC-Mga-059808	Meleagris gallopavo	85.51	0.00e+00	1336.00
IUUC-Mmr-060987	Microcebus murinus	97.60	0.00e+00	2128.00
IUUC-Mmu-064245	Mus musculus	93.46	0.00e+00	1454.00
IUUC-Mpu-066304	Mustela putorius furo	96.14	0.00e+00	2091.00
IUUC-Mlu-067139	Myotis lucifugus	94.38	0.00e+00	1466.00
IUUC-Nle-069075	Nomascus leucogenys	99.74	0.00e+00	1474.00
IUUC-Ont-072150	Oreochromis niloticus	73.78	0.00e+00	1692.00
IUUC-Oan-073054	Ornithorhynchus anatinus	79.89	0.00e+00	1746.00
IUUC-Ocu-074102	Oryctolagus cuniculus	94.80	0.00e+00	2128.00
IUUC-Ola-086529	Oryzias latipes	69.79	0.00e+00	1550.00
IUUC-Oga-088939	Otolemur garnettii	95.40	0.00e+00	1436.00
IUUC-Oar-090266	Ovis aries	96.31	0.00e+00	2100.00
IUUC-Ptr-090546	Pan troglodytes	99.36	0.00e+00	1469.00
IUUC-Pan-092311	Papio anubis	99.91	0.00e+00	2202.00
IUUC-Psi-093459	Pelodiscus sinensis	90.54	0.00e+00	1160.00
IUUC-Pfo-096726	Poecilia formosa	73.29	0.00e+00	1691.00
IUUC-Pab-097608	Pongo abelii	96.13	0.00e+00	2044.00
IUUC-Pca-100718	Procavia capensis	83.13	0.00e+00	1416.00
IUUC-Pva-103150	Pteropus vampyrus	91.10	0.00e+00	1501.00
IUUC-Rno-105727	Rattus norvegicus	94.23	0.00e+00	1422.00
IUUC-Sha-107051	Sarcophilus harrisii	89.65	0.00e+00	1353.00
IUUC-Sar-113097	Sorex araneus	85.50	0.00e+00	1831.00
IUUC-Ssc-115877	Sus scrofa	94.03	0.00e+00	1426.00
IUUC-Tgu-117473	Taeniopygia guttata	75.87	0.00e+00	1677.00
IUUC-Tru-118135	Takifugu rubripes	65.96	0.00e+00	1419.00
IUUC-Tsy-119471	Tarsius syrichta	89.87	0.00e+00	1845.00
IUUC-Tni-120139	Tetraodon nigroviridis	70.58	0.00e+00	1015.00
IUUC-Tbe-127549	Tupaia belangeri	87.84	0.00e+00	1867.00
IUUC-Ttr-128896	Tursiops truncatus	89.69	0.00e+00	1960.00
IUUC-Vpa-130500	Vicugna pacos	93.72	0.00e+00	1332.00
IUUC-Xtr-132896	Xenopus tropicalis	81.32	0.00e+00	1259.00
IUUC-Xma-133349	Xiphophorus maculatus	75.12	0.00e+00	1179.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence