iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028234

UUCD1 version

UUC-DaR-01409

Ensembl Protein ID

ENSDARP00000107103.3

UniProt Accession

Q5RGA4; A3KPA5; MYSM1_DANRE

Genbank Protein ID

CAI12031.1; AAI34240.1

Protein Name

Histone H2A deubiquitinase MYSM1; Myb-like, SWIRM and MPN domain-containing protein 1

Genbank Nucleotide ID

BX942841; BC134239

Gene Name

mysm1; si:ch211-59d15.8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000034693.6	ENSDART00000125133.2	ENSDARP00000107103.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/JAMM	69.14	2.00e-175	614.00	IUUC-Hsa-046902

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Functional Description
(View)

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).

Protein Sequence
(Fasta)

MADELDVVDI EGDECDEIVG DLSSAEILQD QYLQSAWRTN SSVLPWTLDS SISDENRQVI 60
ESMLLEEQYY FASKKAPKVA WTNEKTKVKK PLVKSSAAQT RWAEEEKELF EKGLAQFGRR 120

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Nucleotide Sequence
(Fasta)

GCTTCCGGCA CAAATATGGC TGATGAGTTG GATGTTGTTG ACATCGAGGG AGATGAATGT 60
GATGAAATCG TCGGGTAGGA GTTTATTCTC TCATTTCCAT GTTTCTGGGA AACATAACCG 120

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Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR009057--Homeobox-like
IPR000555--JAMM/MPN+_dom
IPR033497--MYSM1
IPR001005--SANT/Myb
IPR017884--SANT_dom
IPR007526--SWIRM
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS51293--SANT
PS50934--SWIRM

Pfam

PF01398--JAB
PF00249--Myb_DNA-binding
PF04433--SWIRM

SMART

SM00232--JAB_MPN
SM00717--SANT

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0006338--P:chromatin remodeling
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

dre:561225

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001270	Ailuropoda melanoleuca	69.21	2.00e-178	620.00
IUUC-Apl-003363	Anas platyrhynchos	53.88	0.00e+00	726.00
IUUC-Aca-005139	Anolis carolinensis	66.44	2.00e-176	612.00
IUUC-Aly-005879	Arabidopsis lyrata	37.93	5.00e-08	52.00
IUUC-Ath-006818	Arabidopsis thaliana	37.93	5.00e-08	52.00
IUUC-Ame-011693	Astyanax mexicanus	66.62	0.00e+00	875.00
IUUC-Bta-013079	Bos taurus	67.33	3.00e-174	605.00
IUUC-Bol-015375	Brassica oleracea	41.38	2.00e-09	56.20
IUUC-Bra-017353	Brassica rapa	39.66	3.00e-08	52.80
IUUC-Cja-019242	Callithrix jacchus	68.26	4.00e-172	598.00
IUUC-Cfa-020562	Canis familiaris	69.21	4.00e-178	618.00
IUUC-Cpo-021656	Cavia porcellus	53.09	0.00e+00	737.00
IUUC-Cre-022774	Chlamydomonas reinhardtii	44.19	9.00e-18	84.70
IUUC-Csa-023482	Chlorocebus sabaeus	68.04	5.00e-171	594.00
IUUC-Cho-024724	Choloepus hoffmanni	62.11	8.00e-60	225.00
IUUC-Cme-027237	Cyanidioschyzon merolae	42.36	1.00e-30	128.00
IUUC-Dno-029985	Dasypus novemcinctus	54.34	0.00e+00	699.00
IUUC-Dor-030957	Dipodomys ordii	51.28	0.00e+00	648.00
IUUC-Ete-032831	Echinops telfairi	67.73	3.00e-166	579.00
IUUC-Eca-033285	Equus caballus	50.61	0.00e+00	695.00
IUUC-Eeu-035164	Erinaceus europaeus	56.15	8.00e-132	464.00
IUUC-Fca-036480	Felis catus	51.37	0.00e+00	713.00
IUUC-Fal-037081	Ficedula albicollis	50.94	0.00e+00	695.00
IUUC-Gmo-039445	Gadus morhua	54.10	0.00e+00	790.00
IUUC-Gga-040639	Gallus gallus	68.72	4.00e-172	598.00
IUUC-Gac-042370	Gasterosteus aculeatus	70.19	1.00e-174	606.00
IUUC-Gma-043648	Glycine max	39.66	2.00e-08	53.10
IUUC-Ggo-044894	Gorilla gorilla	53.59	0.00e+00	732.00
IUUC-Hsa-046902	Homo sapiens	53.13	0.00e+00	721.00
IUUC-Itr-047908	Ictidomys tridecemlineatus	68.98	7.00e-175	607.00
IUUC-Lch-049854	Latimeria chalumnae	65.65	1.00e-165	577.00
IUUC-Loc-052310	Lepisosteus oculatus	74.60	0.00e+00	671.00
IUUC-Laf-053369	Loxodonta africana	69.28	1.00e-172	600.00
IUUC-Mcc-055385	Macaca mulatta	68.04	1.00e-170	593.00
IUUC-Meu-056008	Macropus eugenii	57.30	4.00e-134	472.00
IUUC-Mga-059526	Meleagris gallopavo	61.68	2.00e-145	510.00
IUUC-Mmr-060949	Microcebus murinus	52.04	0.00e+00	743.00
IUUC-Mdo-061821	Monodelphis domestica	52.11	0.00e+00	746.00
IUUC-Mmu-064166	Mus musculus	68.62	0.00e+00	637.00
IUUC-Mpu-065701	Mustela putorius furo	51.32	0.00e+00	753.00
IUUC-Mlu-067089	Myotis lucifugus	51.55	0.00e+00	739.00
IUUC-Nle-069917	Nomascus leucogenys	68.26	3.00e-172	598.00
IUUC-Opr-070449	Ochotona princeps	60.79	7.00e-148	518.00
IUUC-Ont-071468	Oreochromis niloticus	73.81	0.00e+00	642.00
IUUC-Ocu-073867	Oryctolagus cuniculus	81.76	6.00e-69	255.00
IUUC-Ola-087430	Oryzias latipes	68.12	5.00e-178	618.00
IUUC-Olu-087581	Ostreococcus lucimarinus	42.48	2.00e-32	133.00
IUUC-Oga-088967	Otolemur garnettii	68.52	6.00e-170	591.00
IUUC-Oar-089773	Ovis aries	67.56	7.00e-175	607.00
IUUC-Ptr-091260	Pan troglodytes	52.50	0.00e+00	721.00
IUUC-Pan-092564	Papio anubis	68.04	7.00e-171	594.00
IUUC-Psi-094097	Pelodiscus sinensis	67.34	2.00e-166	580.00
IUUC-Pma-094538	Petromyzon marinus	67.33	5.00e-40	158.00
IUUC-Pfo-097392	Poecilia formosa	58.30	0.00e+00	811.00
IUUC-Pab-098496	Pongo abelii	52.39	0.00e+00	715.00
IUUC-Pop-099207	Populus trichocarpa	39.66	2.00e-08	53.50
IUUC-Pca-100438	Procavia capensis	57.85	3.00e-73	270.00
IUUC-Ppe-101933	Prunus persica	35.71	1.00e-08	53.50
IUUC-Pva-103082	Pteropus vampyrus	68.29	2.00e-173	602.00
IUUC-Rno-105976	Rattus norvegicus	54.74	0.00e+00	754.00
IUUC-Sha-106498	Sarcophilus harrisii	65.80	4.00e-165	575.00
IUUC-Sly-111876	Solanum lycopersicum	36.21	1.00e-07	50.80
IUUC-Stu-112613	Solanum tuberosum	37.93	2.00e-08	53.50
IUUC-Sar-113274	Sorex araneus	53.54	0.00e+00	686.00
IUUC-Sre-115088	Sporisorium reilianum	36.26	6.00e-10	60.50
IUUC-Ssc-115653	Sus scrofa	68.29	1.00e-171	597.00
IUUC-Tgu-117140	Taeniopygia guttata	52.94	0.00e+00	713.00
IUUC-Tru-117818	Takifugu rubripes	70.71	3.00e-175	608.00
IUUC-Tsy-118897	Tarsius syrichta	68.52	4.00e-171	595.00
IUUC-Tni-119769	Tetraodon nigroviridis	70.18	0.00e+00	652.00
IUUC-Tbe-127944	Tupaia belangeri	66.58	7.00e-158	551.00
IUUC-Ttr-129252	Tursiops truncatus	68.38	4.00e-153	535.00
IUUC-Vpa-130289	Vicugna pacos	68.98	3.00e-172	598.00
IUUC-Vvi-131499	Vitis vinifera	36.21	1.00e-07	50.80
IUUC-Xtr-131964	Xenopus tropicalis	66.75	2.00e-164	572.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence