iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132138

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine signaling 4

Genbank Nucleotide ID

AAMC01063781

Gene Name

socs4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000012209.3	ENSXETT00000026666.3	ENSXETP00000026666.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.80e-14	52.1	371	417

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            +l r+ p++Lqh+CR aI+ ++ ++++   d+LP P+s+k YL++++y+
   Q: 371  SPLNRTFPFTLQHICRAAICTSTNYDGI---DALPVPSSMKLYLKEYHYK 417
           5678999*********************...****************985 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MAENIEDKLG ELDVRPKSSR SRSADRKDGY VWSGKKLTWL NKNGHSSDGD TINVVEDEDC 60
ATQSQERKHS CSSIELDLDR SCGHKILGRS LKQKLQDAVG QCFPIKTCSN RHSSTLSSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACCAGAGC CGGCAGCTCG GAGAGTGACT AAGGAGTTAA GCAGCAGAGC CGCTGCCATG 60
CATGCCGGGA AGTGCCGGAG TCTGGGTAAT GTAGTTGTGC AGGCAGGAAA TGGCTGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	72.37	2.00e-179	621.00
IUUC-Apl-003839	Anas platyrhynchos	73.17	2.00e-168	585.00
IUUC-Aca-004840	Anolis carolinensis	71.40	0.00e+00	632.00
IUUC-Bta-012503	Bos taurus	72.44	3.00e-180	624.00
IUUC-Bol-016597	Brassica oleracea	41.03	1.90e-01	30.80
IUUC-Cja-019284	Callithrix jacchus	72.89	0.00e+00	627.00
IUUC-Cfa-020890	Canis familiaris	72.44	6.00e-180	623.00
IUUC-Cpo-022081	Cavia porcellus	68.48	3.00e-168	584.00
IUUC-Csa-023076	Chlorocebus sabaeus	72.44	3.00e-180	624.00
IUUC-Cho-024700	Choloepus hoffmanni	71.82	0.00e+00	636.00
IUUC-Dno-029961	Dasypus novemcinctus	72.50	0.00e+00	640.00
IUUC-Dor-030273	Dipodomys ordii	71.36	1.00e-177	615.00
IUUC-Ete-032972	Echinops telfairi	72.03	1.00e-129	455.00
IUUC-Eca-034289	Equus caballus	72.73	2.00e-179	621.00
IUUC-Eeu-035208	Erinaceus europaeus	72.43	8.00e-175	606.00
IUUC-Fal-036829	Ficedula albicollis	72.25	5.00e-166	577.00
IUUC-Gga-040725	Gallus gallus	72.67	1.00e-173	602.00
IUUC-Ggo-044886	Gorilla gorilla	72.67	0.00e+00	626.00
IUUC-Hsa-046322	Homo sapiens	72.44	2.00e-180	624.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	72.35	2.00e-177	615.00
IUUC-Lch-049459	Latimeria chalumnae	54.88	7.00e-132	463.00
IUUC-Laf-053484	Loxodonta africana	72.54	2.00e-176	611.00
IUUC-Mcc-054890	Macaca mulatta	72.21	5.00e-180	623.00
IUUC-Meu-056532	Macropus eugenii	71.39	2.00e-159	555.00
IUUC-Mmr-061714	Microcebus murinus	72.67	2.00e-179	621.00
IUUC-Mmu-063161	Mus musculus	67.65	1.00e-170	592.00
IUUC-Mpu-066499	Mustela putorius furo	72.95	0.00e+00	644.00
IUUC-Mlu-066945	Myotis lucifugus	72.05	2.00e-176	611.00
IUUC-Nle-069976	Nomascus leucogenys	72.44	3.00e-180	624.00
IUUC-Opr-070255	Ochotona princeps	72.44	6.00e-177	613.00
IUUC-Ocu-074764	Oryctolagus cuniculus	71.82	2.00e-176	611.00
IUUC-Oga-088910	Otolemur garnettii	70.81	8.00e-180	622.00
IUUC-Oar-090330	Ovis aries	72.44	4.00e-180	623.00
IUUC-Ptr-090709	Pan troglodytes	72.67	0.00e+00	626.00
IUUC-Pan-092540	Papio anubis	72.44	3.00e-180	624.00
IUUC-Psi-093678	Pelodiscus sinensis	73.18	0.00e+00	654.00
IUUC-Pfo-097139	Poecilia formosa	80.35	2.00e-87	316.00
IUUC-Pab-097970	Pongo abelii	70.78	4.00e-145	507.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.20e-01	30.80
IUUC-Pca-100211	Procavia capensis	63.64	2.00e-149	521.00
IUUC-Rno-106014	Rattus norvegicus	66.59	2.00e-170	592.00
IUUC-Sha-106822	Sarcophilus harrisii	70.14	1.00e-179	622.00
IUUC-Ssc-115821	Sus scrofa	72.50	3.00e-180	624.00
IUUC-Tgu-117117	Taeniopygia guttata	72.48	2.00e-166	578.00
IUUC-Tsy-118979	Tarsius syrichta	88.24	5.00e-112	396.00
IUUC-Vpa-130626	Vicugna pacos	72.95	2.00e-179	621.00
IUUC-Vvi-131327	Vitis vinifera	43.75	9.70e-02	31.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence