iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132676

Ensembl Protein ID

ENSXETP00000030351.3

UniProt Accession

F6XRN6; F6XRN6_XENTR

Genbank Protein ID

ENSXETP00000030351

Protein Name

Rho guanine nucleotide exchange factor 4

Genbank Nucleotide ID

AAMC01022273

Gene Name

arhgef4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000013866.3	ENSXETT00000030351.3	ENSXETP00000030351.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UFD/PB1	32.85	1.00e-18	89.70	IUUC-Sce-106197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

FNDGSTNRPS LFDDLGSDED FYEELHVSGH RFVGGGEQLA INELISDGSV VYAEALWDHV 60
TMDDEELGFK AGSVIEVMDA TNKEWWWGRI LDSEGWFPAS FVRLRVNQDE PMEDCATKAG 120

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Nucleotide Sequence
(Fasta)

TTCAATGATG GGTCTACGAA CAGACCTTCG CTGTTTGATG ACTTGGGGAG TGATGAGGAT 60
TTTTATGAAG AACTACACGT TTCTGGTCAC CGCTTTGTTG GAGGGGGCGA GCAGCTGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00621--RhoGEF
PF00018--SH3_1

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002073	Ailuropoda melanoleuca	64.52	0.00e+00	707.00
IUUC-Apl-004117	Anas platyrhynchos	68.09	0.00e+00	757.00
IUUC-Aca-004793	Anolis carolinensis	66.07	0.00e+00	717.00
IUUC-Ago-008003	Ashbya gossypii	28.81	2.00e-15	78.20
IUUC-Ame-010682	Astyanax mexicanus	54.58	2.00e-171	596.00
IUUC-Bta-013253	Bos taurus	69.20	0.00e+00	791.00
IUUC-Cja-019555	Callithrix jacchus	64.87	0.00e+00	701.00
IUUC-Cfa-020578	Canis familiaris	64.52	0.00e+00	710.00
IUUC-Csa-023331	Chlorocebus sabaeus	69.38	0.00e+00	796.00
IUUC-Cho-025069	Choloepus hoffmanni	37.02	9.00e-57	216.00
IUUC-Cin-025453	Ciona intestinalis	52.20	9.00e-125	440.00
IUUC-Csv-025922	Ciona savignyi	45.63	4.00e-98	352.00
IUUC-Dre-028197	Danio rerio	75.50	0.00e+00	849.00
IUUC-Dno-029679	Dasypus novemcinctus	66.07	0.00e+00	697.00
IUUC-Dor-030739	Dipodomys ordii	70.11	0.00e+00	807.00
IUUC-Dme-031672	Drosophila melanogaster	29.39	6.00e-23	102.00
IUUC-Ete-032545	Echinops telfairi	38.67	5.00e-46	180.00
IUUC-Eca-034299	Equus caballus	64.87	0.00e+00	700.00
IUUC-Eeu-034720	Erinaceus europaeus	36.77	2.00e-58	221.00
IUUC-Fca-036416	Felis catus	66.73	0.00e+00	650.00
IUUC-Fal-037035	Ficedula albicollis	67.74	0.00e+00	752.00
IUUC-Gmo-039587	Gadus morhua	74.63	0.00e+00	829.00
IUUC-Ggr-039728	Gaeumannomyces graminis	25.20	4.00e-11	63.50
IUUC-Gga-040841	Gallus gallus	80.11	0.00e+00	930.00
IUUC-Gac-042498	Gasterosteus aculeatus	77.10	0.00e+00	841.00
IUUC-Ggo-044700	Gorilla gorilla	37.29	6.00e-59	223.00
IUUC-Hsa-045681	Homo sapiens	67.48	0.00e+00	673.00
IUUC-Itr-048380	Ictidomys tridecemlineatus	64.82	0.00e+00	701.00
IUUC-Kpa-049278	Komagataella pastoris	29.57	6.00e-19	89.70
IUUC-Lch-049639	Latimeria chalumnae	72.41	0.00e+00	800.00
IUUC-Loc-051994	Lepisosteus oculatus	77.40	0.00e+00	888.00
IUUC-Laf-054307	Loxodonta africana	65.71	0.00e+00	726.00
IUUC-Mcc-055305	Macaca mulatta	68.65	4.00e-146	510.00
IUUC-Meu-056376	Macropus eugenii	80.62	0.00e+00	751.00
IUUC-Mor-057139	Magnaporthe oryzae	26.17	1.00e-12	68.90
IUUC-Mpo-057433	Magnaporthe poae	25.38	6.00e-09	56.60
IUUC-Mla-059044	Melampsora laricipopulina	24.67	1.00e-19	92.40
IUUC-Mga-059644	Meleagris gallopavo	66.73	0.00e+00	737.00
IUUC-Mvi-060486	Microbotryum violaceum	28.00	4.00e-25	110.00
IUUC-Mmr-061664	Microcebus murinus	65.09	0.00e+00	678.00
IUUC-Mdo-062404	Monodelphis domestica	37.29	8.00e-59	223.00
IUUC-Mmu-063143	Mus musculus	37.57	3.00e-59	224.00
IUUC-Mpu-066851	Mustela putorius furo	64.70	0.00e+00	672.00
IUUC-Mlu-066956	Myotis lucifugus	65.77	0.00e+00	696.00
IUUC-Nle-069174	Nomascus leucogenys	39.07	5.00e-41	160.00
IUUC-Opr-070209	Ochotona princeps	64.65	0.00e+00	694.00
IUUC-Ont-072637	Oreochromis niloticus	77.03	0.00e+00	838.00
IUUC-Oan-073722	Ornithorhynchus anatinus	63.23	0.00e+00	696.00
IUUC-Ocu-074885	Oryctolagus cuniculus	66.17	0.00e+00	681.00
IUUC-Ola-087155	Oryzias latipes	36.74	3.00e-57	217.00
IUUC-Oga-088758	Otolemur garnettii	64.86	0.00e+00	692.00
IUUC-Oar-089923	Ovis aries	68.84	0.00e+00	795.00
IUUC-Ptr-091555	Pan troglodytes	65.23	0.00e+00	719.00
IUUC-Pan-092037	Papio anubis	64.58	0.00e+00	726.00
IUUC-Psi-093865	Pelodiscus sinensis	67.38	0.00e+00	755.00
IUUC-Pfo-096918	Poecilia formosa	35.96	4.00e-57	217.00
IUUC-Pab-097910	Pongo abelii	65.41	0.00e+00	733.00
IUUC-Pca-100891	Procavia capensis	38.39	1.00e-54	208.00
IUUC-Pva-102967	Pteropus vampyrus	67.68	3.00e-154	538.00
IUUC-Pgr-103400	Puccinia graminis	25.44	4.00e-22	100.00
IUUC-Rno-105479	Rattus norvegicus	36.39	2.00e-55	211.00
IUUC-Sce-106197	Saccharomyces cerevisiae	32.41	4.00e-19	90.10
IUUC-Sha-107592	Sarcophilus harrisii	65.17	0.00e+00	709.00
IUUC-Spo-108284	Schizosaccharomyces pombe	29.06	1.00e-18	88.60
IUUC-Ssl-108541	Sclerotinia sclerotiorum	24.49	2.00e-16	81.30
IUUC-Sar-113369	Sorex araneus	66.23	3.00e-120	425.00
IUUC-Sre-115126	Sporisorium reilianum	30.05	4.00e-23	103.00
IUUC-Tgu-117088	Taeniopygia guttata	80.54	0.00e+00	929.00
IUUC-Tru-118716	Takifugu rubripes	36.13	6.00e-56	213.00
IUUC-Tsy-118846	Tarsius syrichta	63.32	2.00e-127	448.00
IUUC-Tni-120887	Tetraodon nigroviridis	36.36	5.00e-56	213.00
IUUC-Tur-126327	Triticum urartu	28.23	2.20e-01	30.40
IUUC-Tme-127216	Tuber melanosporum	27.27	3.00e-25	110.00
IUUC-Tbe-127248	Tupaia belangeri	38.39	3.00e-54	207.00
IUUC-Uma-129594	Ustilago maydis	29.58	3.00e-23	103.00
IUUC-Vda-129831	Verticillium dahliae	29.14	1.00e-11	65.50
IUUC-Vpa-130750	Vicugna pacos	38.97	5.00e-57	216.00
IUUC-Xma-133871	Xiphophorus maculatus	35.96	4.00e-57	217.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence