iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022519

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02047557

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000002781.3	ENSCPOT00000002816.2	ENSCPOP00000002526.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-38	132.9	390	695

Active Site

Position(s)	Description	Evidence
665	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 9    levefvg..EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsks 95
           +ev f +  + g +++G+++efl+ll+++l+n+     +++ + +++l+ n +++     +++l++ +G++l+++l++g + + ++sk+
   Q: 390  IEVVFIEsdNFGREHPGSKQEFLSLLMEHLENSP----VFEGSLSKNLSLNAQAI-----KENLYYEAGKMLAISLVHGGPSPGFFSKT 469
           6777777445699********************9....46777888888888886.....579************************** PP
   S: 96   fyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
           ++++l+  +   e+++ + +++ ++ + +i  + +++ +    dl+     ++++e++++    g+ +   + ++k++  ++++ y++ 
   Q: 470  LFNCLVYGP---ENTQPILDDVSDFhMAQIIIRIKTSKNMD--DLN-----SVINECYNYLEPIGCLRLITALTDKYMLAEDILVYHVI 548
           ********8...89999999998887777776643222222..334.....3477888886666888999999**************** PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq....F 267
           ++++  +e+f++G++++  le+++++ e   ++l+++ e+++++ l++   ++ ++  + pa+  Fw+ + +++++ + +  ++    F
   Q: 549  KRVQAPFESFKQGLKTLGVLEKIQMYPEAFYNILCHKAENLSAKILRD--LFTVHTLTSVPAL-GFWNKYlQSVEDGKSAITMEdilvF 634
           ***********************************************9..7888889999998.888755488888887654444444* PP
   S: 268  vTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +Tg+s++P++Gf++ + ++ +++      ++P  n+C n+L LP  s++e+++e++ +Ai++t +++
   Q: 635  ATGCSSIPPAGFKPTP-SIECLHM-----DFPIGNKCENCLALPITSTYEKFQENMDFAIKNTLRLG 695
           ***************9.9999999.....*********************************87665 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MNENKPGDSQ NLACVFCRKN DDCANKYGEK KTNEKWNLTV HYYCLLMSSG IWQRGEEEEG 60
VYGFLIEDIR KEVNRASKLK CSVCKKNGAS IGCVAPRCKR SYHFPCGLQR ECIFQFTGNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATGAAA ATAAACCTGG TGACTCGCAG AACCTTGGTA AGTAACTATT TAAAATATTT 60
AAAAGACAGT AAGTCTTTTT AGAATGCTTT CCATATTCTA GGAATGAATT TCCTGATTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	87.39	0.00e+00	1312.00
IUUC-Apl-003763	Anas platyrhynchos	59.60	0.00e+00	842.00
IUUC-Aca-004328	Anolis carolinensis	59.94	0.00e+00	858.00
IUUC-Ame-011288	Astyanax mexicanus	41.05	6.00e-162	564.00
IUUC-Bta-012496	Bos taurus	84.33	0.00e+00	1255.00
IUUC-Cja-019756	Callithrix jacchus	85.49	0.00e+00	1268.00
IUUC-Cfa-020806	Canis familiaris	87.11	0.00e+00	1304.00
IUUC-Csa-023957	Chlorocebus sabaeus	86.40	0.00e+00	1288.00
IUUC-Cho-024375	Choloepus hoffmanni	80.38	0.00e+00	1137.00
IUUC-Cin-025325	Ciona intestinalis	41.89	2.00e-67	248.00
IUUC-Csv-026262	Ciona savignyi	43.00	3.00e-68	252.00
IUUC-Dre-027829	Danio rerio	40.40	4.00e-154	538.00
IUUC-Dno-029362	Dasypus novemcinctus	85.21	0.00e+00	1248.00
IUUC-Dor-030710	Dipodomys ordii	80.03	0.00e+00	1199.00
IUUC-Dme-031692	Drosophila melanogaster	35.79	4.00e-43	169.00
IUUC-Ete-032282	Echinops telfairi	76.39	0.00e+00	1087.00
IUUC-Eca-033963	Equus caballus	85.55	0.00e+00	1292.00
IUUC-Eeu-035029	Erinaceus europaeus	83.50	0.00e+00	1249.00
IUUC-Fca-036229	Felis catus	86.69	0.00e+00	1308.00
IUUC-Fal-037015	Ficedula albicollis	56.99	0.00e+00	856.00
IUUC-Gmo-039715	Gadus morhua	39.73	1.00e-76	280.00
IUUC-Gga-040298	Gallus gallus	57.94	0.00e+00	887.00
IUUC-Gac-041444	Gasterosteus aculeatus	38.61	1.00e-141	496.00
IUUC-Ggo-045456	Gorilla gorilla	85.98	0.00e+00	1277.00
IUUC-Hsa-046297	Homo sapiens	85.98	0.00e+00	1283.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	86.68	0.00e+00	907.00
IUUC-Lch-050287	Latimeria chalumnae	65.49	1.00e-103	370.00
IUUC-Loc-052839	Lepisosteus oculatus	54.13	2.00e-31	127.00
IUUC-Laf-053581	Loxodonta africana	83.88	0.00e+00	1233.00
IUUC-Mcc-055615	Macaca mulatta	86.12	0.00e+00	1285.00
IUUC-Meu-056753	Macropus eugenii	50.38	8.00e-71	261.00
IUUC-Mga-059902	Meleagris gallopavo	58.16	0.00e+00	893.00
IUUC-Mmr-061522	Microcebus murinus	87.25	0.00e+00	1296.00
IUUC-Mdo-063022	Monodelphis domestica	64.32	0.00e+00	879.00
IUUC-Mmu-063609	Mus musculus	73.90	0.00e+00	1137.00
IUUC-Mpu-066656	Mustela putorius furo	86.54	0.00e+00	1308.00
IUUC-Mlu-067011	Myotis lucifugus	84.44	0.00e+00	1247.00
IUUC-Nle-069949	Nomascus leucogenys	85.69	0.00e+00	1279.00
IUUC-Opr-071224	Ochotona princeps	82.33	8.00e-129	454.00
IUUC-Ont-072174	Oreochromis niloticus	37.33	7.00e-140	491.00
IUUC-Oan-072712	Ornithorhynchus anatinus	65.18	0.00e+00	937.00
IUUC-Ocu-073776	Oryctolagus cuniculus	87.82	0.00e+00	1293.00
IUUC-Ola-087247	Oryzias latipes	38.27	8.00e-134	470.00
IUUC-Oga-088094	Otolemur garnettii	83.79	0.00e+00	1170.00
IUUC-Oar-090248	Ovis aries	83.90	0.00e+00	1241.00
IUUC-Ptr-090634	Pan troglodytes	86.12	0.00e+00	1282.00
IUUC-Pan-092876	Papio anubis	86.26	0.00e+00	1286.00
IUUC-Psi-093580	Pelodiscus sinensis	60.83	0.00e+00	874.00
IUUC-Pma-094295	Petromyzon marinus	53.36	3.00e-72	264.00
IUUC-Pfo-096351	Poecilia formosa	37.70	2.00e-146	512.00
IUUC-Pab-097596	Pongo abelii	86.69	0.00e+00	1294.00
IUUC-Pca-100309	Procavia capensis	78.47	0.00e+00	1159.00
IUUC-Pva-102526	Pteropus vampyrus	88.36	0.00e+00	819.00
IUUC-Rno-105432	Rattus norvegicus	78.77	0.00e+00	1177.00
IUUC-Sha-107089	Sarcophilus harrisii	64.60	0.00e+00	989.00
IUUC-Sar-113667	Sorex araneus	64.86	0.00e+00	923.00
IUUC-Ssc-116200	Sus scrofa	86.26	0.00e+00	1283.00
IUUC-Tgu-116467	Taeniopygia guttata	56.87	0.00e+00	839.00
IUUC-Tru-117690	Takifugu rubripes	38.22	3.00e-152	532.00
IUUC-Tsy-119481	Tarsius syrichta	84.40	0.00e+00	886.00
IUUC-Tni-119669	Tetraodon nigroviridis	37.32	9.00e-134	470.00
IUUC-Tbe-127241	Tupaia belangeri	79.37	0.00e+00	1125.00
IUUC-Ttr-129057	Tursiops truncatus	77.34	0.00e+00	1103.00
IUUC-Vpa-130685	Vicugna pacos	84.76	0.00e+00	1224.00
IUUC-Xtr-132555	Xenopus tropicalis	52.88	0.00e+00	743.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence