iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-116200

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CT954260

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000001974.2	ENSSSCT00000002207.2	ENSSSCP00000002155.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.00e-40	137.9	387	695

Active Site

Position(s)	Description	Evidence
665	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev + +E+   g +++G+++efl+ll+++l+n+   lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++
   Q: 387  YTIEVVYINENdrfGREQPGSKQEFLSLLMQQLENSP--LF--EGSLSKNLSLNSQAL-----KENLYYEAGKMLAISLVHGGPSPGFF 466
           57899999999999*********************99..56..677777888888885.....689*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++++l+  +   e+++ + +++ ++ + +i  +   ++ ++ +dl++      +++++++  + g+ +    +++k++  k+++ y
   Q: 467  SKTLFNCLVYGP---ENTQPILDDVSDFdVAQIIIRI--NTATSVADLNSL-----INDCYNYLELIGCLRLITSISDKYMLAKDILVY 545
           ***********8...*************988888774..555555677754.....88999**999*********************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ ++++  +e+f++G++++  le+++ + e  +++++++ e+++++ l++   ++ ++ +d +a+  Fw+ + +++++ + +  ++  
   Q: 546  HVIKRVQAPFESFKQGLKTLGVLEKIQTYPEAFCNIFCHKPESLSAKILSD--LFTVHTLSDVQAL-GFWNSYlQAIEDGKSTVTMEdi 631
           *************************************************99..7888889999997.9999875778777766555555 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
             F+Tg++++P++Gf++ + ++ +++      ++P  n+C n+L LP  s++++++e++ +Ai++t ++e
   Q: 632  liFATGCNSIPPAGFKPTP-SIECLHM-----DFPVGNKCNNCLALPITSTYKEFQENMDFAIKNTLRLE 695
           55****************9.9999999.....*********************************87665 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MNENKPGGSQ NLACVFCRKN DDCPVKYGEK KTNEKWNLTV HYYCLLMSSG IWQRGKEEEG 60
VYGFLIEDIK KEVTRASKLK CCICKKTGAS IGCVAPRCKR SYHFPCGLQR ECIFQFTGNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAACTCTC CTTCCGGGTT GCGGGCGGAA GTGGACGAAT TTGAATTGTG CGGGCCGTTG 60
GATGGGGTGT TCTCGGATGG CCTGTGGCGC AGCGCGAGAA GAGAAAGGTG ACACGGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	91.36	0.00e+00	1363.00
IUUC-Apl-003763	Anas platyrhynchos	58.92	0.00e+00	837.00
IUUC-Aca-004328	Anolis carolinensis	60.52	0.00e+00	864.00
IUUC-Ame-011288	Astyanax mexicanus	39.77	8.00e-161	560.00
IUUC-Bta-012496	Bos taurus	91.74	0.00e+00	1358.00
IUUC-Cja-019756	Callithrix jacchus	89.47	0.00e+00	1321.00
IUUC-Cfa-020806	Canis familiaris	90.79	0.00e+00	1357.00
IUUC-Cpo-022519	Cavia porcellus	86.26	0.00e+00	1264.00
IUUC-Csa-023957	Chlorocebus sabaeus	89.66	0.00e+00	1342.00
IUUC-Cho-024375	Choloepus hoffmanni	82.68	0.00e+00	1182.00
IUUC-Cin-025325	Ciona intestinalis	42.57	1.00e-68	252.00
IUUC-Csv-026262	Ciona savignyi	42.66	1.00e-68	253.00
IUUC-Dre-027829	Danio rerio	40.31	8.00e-152	530.00
IUUC-Dno-029362	Dasypus novemcinctus	88.26	0.00e+00	1303.00
IUUC-Dor-030710	Dipodomys ordii	82.72	0.00e+00	1244.00
IUUC-Dse-031248	Dothistroma septosporum	40.38	5.00e-04	40.00
IUUC-Dme-031692	Drosophila melanogaster	33.57	1.00e-41	164.00
IUUC-Ete-032282	Echinops telfairi	78.44	0.00e+00	1130.00
IUUC-Eca-033963	Equus caballus	90.79	0.00e+00	1357.00
IUUC-Eeu-035029	Erinaceus europaeus	87.09	0.00e+00	1305.00
IUUC-Fca-036229	Felis catus	92.78	0.00e+00	1380.00
IUUC-Fal-037015	Ficedula albicollis	57.90	0.00e+00	866.00
IUUC-Gmo-039715	Gadus morhua	39.89	1.00e-79	289.00
IUUC-Gga-040298	Gallus gallus	58.02	0.00e+00	884.00
IUUC-Gac-041444	Gasterosteus aculeatus	38.69	5.00e-141	494.00
IUUC-Ggo-045456	Gorilla gorilla	89.09	0.00e+00	1332.00
IUUC-Hsa-046297	Homo sapiens	89.52	0.00e+00	1340.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	88.67	0.00e+00	939.00
IUUC-Lch-050287	Latimeria chalumnae	64.57	7.00e-104	371.00
IUUC-Loc-052839	Lepisosteus oculatus	55.96	8.00e-32	128.00
IUUC-Laf-053581	Loxodonta africana	87.16	0.00e+00	1285.00
IUUC-Mcc-055615	Macaca mulatta	89.66	0.00e+00	1342.00
IUUC-Meu-056753	Macropus eugenii	48.88	3.00e-128	452.00
IUUC-Mga-059902	Meleagris gallopavo	57.73	0.00e+00	884.00
IUUC-Mmr-061522	Microcebus murinus	90.92	0.00e+00	1359.00
IUUC-Mdo-063022	Monodelphis domestica	64.67	0.00e+00	892.00
IUUC-Mmu-063609	Mus musculus	76.17	0.00e+00	1153.00
IUUC-Mpu-066656	Mustela putorius furo	90.93	0.00e+00	1363.00
IUUC-Mlu-067011	Myotis lucifugus	89.19	0.00e+00	1310.00
IUUC-Nle-069949	Nomascus leucogenys	89.24	0.00e+00	1334.00
IUUC-Opr-071224	Ochotona princeps	84.59	4.00e-135	474.00
IUUC-Ont-072174	Oreochromis niloticus	37.59	4.00e-138	484.00
IUUC-Oan-072712	Ornithorhynchus anatinus	67.00	0.00e+00	968.00
IUUC-Ocu-073776	Oryctolagus cuniculus	89.52	0.00e+00	1329.00
IUUC-Ola-087247	Oryzias latipes	37.62	3.00e-130	459.00
IUUC-Oga-088094	Otolemur garnettii	87.10	0.00e+00	1231.00
IUUC-Oar-090248	Ovis aries	91.74	0.00e+00	1352.00
IUUC-Ptr-090634	Pan troglodytes	89.38	0.00e+00	1338.00
IUUC-Pan-092876	Papio anubis	89.80	0.00e+00	1343.00
IUUC-Psi-093580	Pelodiscus sinensis	60.26	0.00e+00	870.00
IUUC-Pma-094295	Petromyzon marinus	54.15	4.00e-73	267.00
IUUC-Pfo-096351	Poecilia formosa	38.51	2.00e-145	509.00
IUUC-Pab-097596	Pongo abelii	90.08	0.00e+00	1345.00
IUUC-Pca-100309	Procavia capensis	80.59	0.00e+00	1195.00
IUUC-Pva-102526	Pteropus vampyrus	91.55	0.00e+00	844.00
IUUC-Rno-105432	Rattus norvegicus	80.23	0.00e+00	1198.00
IUUC-Sha-107089	Sarcophilus harrisii	65.07	0.00e+00	1009.00
IUUC-Sar-113667	Sorex araneus	67.43	0.00e+00	966.00
IUUC-Tgu-116467	Taeniopygia guttata	57.36	0.00e+00	852.00
IUUC-Tru-117690	Takifugu rubripes	39.06	2.00e-153	536.00
IUUC-Tsy-119481	Tarsius syrichta	86.60	0.00e+00	902.00
IUUC-Tni-119669	Tetraodon nigroviridis	36.85	6.00e-132	464.00
IUUC-Tbe-127241	Tupaia belangeri	80.77	0.00e+00	1155.00
IUUC-Ttr-129057	Tursiops truncatus	85.53	0.00e+00	1216.00
IUUC-Vpa-130685	Vicugna pacos	91.74	0.00e+00	1329.00
IUUC-Xtr-132555	Xenopus tropicalis	52.89	0.00e+00	744.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence