iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-006710

UUCD1 version

UUC-ArT-01711

Ensembl Protein ID

AT5G57990.1

UniProt Accession

Q9FPS4; Q9FJL7; UBP23_ARATH

Genbank Protein ID

AAG42761.1; BAB08869.1; AED96982.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 23; Deubiquitinating enzyme 23; Ubiquitin thioesterase 23; Ubiquitin-specific-processing protease 23

Genbank Nucleotide ID

AF302671; AB013396; CP002688

Gene Name

UBP23; At5g57990; MTI20.25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G57990	AT5G57990.1	AT5G57990.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-79	267.1	108	409

Active Site

Position(s)	Description	Evidence
116	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
369	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflafl 99
           Gl+NlgNtC++NSvLQcL+ +++l+  l +  ++k  +        + l+++qk ++   + + +  +p++l++ l+ ++++f++ +q+Da+E++  l
   Q: 108  GLQNLGNTCFLNSVLQCLTYTEPLAATLQTAAHQKYCHV----AGFCALCAIQKHVRTARQANGRILAPKDLVSNLRCISRNFRNCRQEDAHEYMINL 201
           9*****************************655555554....468999************************************************* PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftke 197
           l+ +++                     s   +e+ +   +sl++++F+g+l+sq+kc++c + s++++pfldlsl++++ +     slq +L+ ft+ 
   Q: 202  LECMHKCS-----------------LPSGVPSESSDAYRRSLVHKIFGGSLRSQVKCEQCSHCSNKFDPFLDLSLDISKAD-----SLQRALSRFTAV 277
           ******88.................122334557788999*****************************************.....9*********** PP
   S: 198  eelegenk.yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssG 293
           e l++  k y+ce+ck+k++a+k+l+++k P vL++hLkRf    e +++eki++kv+f   +d++pf++ p e+   + kY L++v+vH+G s++sG
   Q: 278  ELLDNGAKvYQCERCKQKVKAKKQLTVSKAPYVLTVHLKRF----EAHRSEKIDRKVDFTSAIDMKPFVSGPHEG---NLKYTLYGVLVHYGrSSHSG 368
           ***876666********************************....447789********************9988...79****************** PP
   S: 294  HYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           HY ++v+ ++g W+ +dD++V +v+e++v +   ++aY+lfY r
   Q: 369  HYACFVRTSSGMWYSLDDNRVVQVSEKTVFN---QKAYMLFYVR 409
           *******************************...********87 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MEVATSSTEI TIQTDRDPSS NNNGSCAVAS STASAVFRKI EFHPARKPFN GFSNGRSDFK 60
IETLNPCSSN QRLLSAPSAK KPDSSDLLEH GFEPDLTFSI TFRKIGAGLQ NLGNTCFLNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAATAAAAT AAGTGGCTGG GTCTTTAGCT AGGGTTTAAT AGTGCGTTGC AGCTTCCGCT 60
CTCTTTCTCT CCTTTCTTTT CACACAGCCG CAAAGGCTCT CATCTTCTTC TTCATTCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G57990

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000845	Aegilops tauschii	62.50	7.00e-104	371.00
IUUC-Aml-002092	Ailuropoda melanoleuca	33.70	8.00e-72	265.00
IUUC-Atr-003102	Amborella trichopoda	63.38	4.00e-152	531.00
IUUC-Apl-003459	Anas platyrhynchos	39.61	1.00e-66	248.00
IUUC-Aca-004440	Anolis carolinensis	44.16	1.00e-81	297.00
IUUC-Aly-006389	Arabidopsis lyrata	88.34	0.00e+00	1472.00
IUUC-Ago-007836	Ashbya gossypii	28.49	6.00e-32	132.00
IUUC-Ame-011358	Astyanax mexicanus	45.42	3.00e-80	293.00
IUUC-Bta-013047	Bos taurus	43.46	2.00e-76	280.00
IUUC-Bdi-014036	Brachypodium distachyon	61.30	2.00e-140	492.00
IUUC-Bol-015996	Brassica oleracea	64.69	0.00e+00	1011.00
IUUC-Bra-016634	Brassica rapa	59.30	0.00e+00	902.00
IUUC-Cel-018186	Caenorhabditis elegans	33.03	5.00e-41	161.00
IUUC-Cja-019203	Callithrix jacchus	38.46	4.00e-77	282.00
IUUC-Cfa-020586	Canis familiaris	38.17	3.00e-71	263.00
IUUC-Cpo-021804	Cavia porcellus	38.46	2.00e-70	260.00
IUUC-Cre-022988	Chlamydomonas reinhardtii	38.34	3.00e-54	204.00
IUUC-Csa-023137	Chlorocebus sabaeus	38.36	1.00e-76	280.00
IUUC-Cho-024575	Choloepus hoffmanni	37.45	3.00e-51	196.00
IUUC-Cin-025230	Ciona intestinalis	39.94	9.00e-56	209.00
IUUC-Cme-027339	Cyanidioschyzon merolae	39.42	6.00e-58	217.00
IUUC-Dre-028442	Danio rerio	44.63	6.00e-79	288.00
IUUC-Dno-029149	Dasypus novemcinctus	39.49	3.00e-71	263.00
IUUC-Dor-030836	Dipodomys ordii	29.62	2.00e-55	210.00
IUUC-Dme-032119	Drosophila melanogaster	36.78	1.00e-49	191.00
IUUC-Ete-033088	Echinops telfairi	39.02	3.00e-68	253.00
IUUC-Eca-033600	Equus caballus	43.46	3.00e-71	263.00
IUUC-Eeu-035019	Erinaceus europaeus	39.62	1.00e-58	219.00
IUUC-Fca-035792	Felis catus	42.36	2.00e-75	277.00
IUUC-Fal-036852	Ficedula albicollis	42.72	4.00e-69	255.00
IUUC-Gmo-039033	Gadus morhua	39.07	2.00e-77	283.00
IUUC-Gga-040664	Gallus gallus	43.97	2.00e-71	263.00
IUUC-Gac-042176	Gasterosteus aculeatus	39.33	8.00e-77	281.00
IUUC-Gma-043113	Glycine max	66.90	1.00e-171	596.00
IUUC-Ggo-045437	Gorilla gorilla	42.36	2.00e-70	260.00
IUUC-Hsa-046072	Homo sapiens	42.48	3.00e-76	280.00
IUUC-Hvu-047306	Hordeum vulgare	68.63	2.00e-104	370.00
IUUC-Itr-048655	Ictidomys tridecemlineatus	40.62	2.00e-77	283.00
IUUC-Lch-049867	Latimeria chalumnae	43.51	2.00e-78	286.00
IUUC-Lpe-051574	Leersia perrieri	54.46	5.00e-133	468.00
IUUC-Loc-052621	Lepisosteus oculatus	44.44	2.00e-77	284.00
IUUC-Laf-054330	Loxodonta africana	42.35	8.00e-78	284.00
IUUC-Mcc-055762	Macaca mulatta	42.36	4.00e-76	279.00
IUUC-Meu-056697	Macropus eugenii	36.76	1.00e-72	267.00
IUUC-Mtr-058537	Medicago truncatula	61.22	6.00e-162	563.00
IUUC-Mla-059049	Melampsora laricipopulina	36.89	2.00e-52	200.00
IUUC-Mga-059501	Meleagris gallopavo	40.20	2.00e-65	244.00
IUUC-Mvi-060547	Microbotryum violaceum	40.37	3.00e-66	246.00
IUUC-Mmr-060966	Microcebus murinus	43.63	1.00e-70	260.00
IUUC-Mdo-062733	Monodelphis domestica	36.99	4.00e-73	269.00
IUUC-Mmu-064236	Mus musculus	42.81	4.00e-77	282.00
IUUC-Mac-065039	Musa acuminata	64.22	5.00e-162	564.00
IUUC-Mpu-065759	Mustela putorius furo	38.42	8.00e-72	265.00
IUUC-Mlu-067091	Myotis lucifugus	42.36	3.00e-76	280.00
IUUC-Nle-069004	Nomascus leucogenys	42.36	2.00e-76	280.00
IUUC-Opr-070729	Ochotona princeps	33.10	5.00e-66	245.00
IUUC-Ont-071346	Oreochromis niloticus	38.82	3.00e-78	286.00
IUUC-Oan-073711	Ornithorhynchus anatinus	43.69	3.00e-77	283.00
IUUC-Ocu-074596	Oryctolagus cuniculus	42.35	2.00e-76	279.00
IUUC-Oba-075866	Oryza barthii	54.30	1.00e-140	493.00
IUUC-Obr-076408	Oryza brachyantha	60.78	1.00e-142	499.00
IUUC-Ogl-077239	Oryza glaberrima	54.53	9.00e-142	497.00
IUUC-Ogu-078064	Oryza glumaepatula	54.53	6.00e-142	498.00
IUUC-Oin-079157	Oryza indica	60.35	2.00e-141	495.00
IUUC-Olo-080231	Oryza longistaminata	53.47	1.00e-117	417.00
IUUC-Ome-081746	Oryza meridionalis	54.88	6.00e-139	487.00
IUUC-Oni-082339	Oryza nivara	60.35	3.00e-141	495.00
IUUC-Opu-083194	Oryza punctata	55.31	5.00e-142	499.00
IUUC-Oru-085083	Oryza rufipogon	60.35	2.00e-141	496.00
IUUC-Osa-086180	Oryza sativa	60.35	4.00e-141	495.00
IUUC-Ola-087255	Oryzias latipes	42.16	1.00e-76	281.00
IUUC-Olu-087773	Ostreococcus lucimarinus	47.15	3.00e-72	264.00
IUUC-Oga-088818	Otolemur garnettii	39.57	3.00e-71	263.00
IUUC-Oar-089760	Ovis aries	42.48	6.00e-76	278.00
IUUC-Ptr-091445	Pan troglodytes	42.36	2.00e-76	280.00
IUUC-Pan-092482	Papio anubis	38.36	4.00e-76	279.00
IUUC-Psi-093277	Pelodiscus sinensis	42.50	9.00e-79	288.00
IUUC-Ppa-095853	Physcomitrella patens	50.90	3.00e-112	399.00
IUUC-Pfo-096807	Poecilia formosa	39.07	5.00e-79	288.00
IUUC-Pab-097794	Pongo abelii	42.48	5.00e-76	279.00
IUUC-Pop-099067	Populus trichocarpa	41.33	6.00e-179	620.00
IUUC-Ppe-101678	Prunus persica	69.02	7.00e-172	597.00
IUUC-Pva-103238	Pteropus vampyrus	37.58	5.00e-64	239.00
IUUC-Pgr-103270	Puccinia graminis	40.06	6.00e-60	224.00
IUUC-Ptt-103887	Puccinia triticina	39.81	2.00e-58	220.00
IUUC-Rno-105068	Rattus norvegicus	42.81	2.00e-77	283.00
IUUC-Sha-107019	Sarcophilus harrisii	37.61	4.00e-74	272.00
IUUC-Smo-108763	Selaginella moellendorffii	55.48	1.00e-96	345.00
IUUC-Sit-109895	Setaria italica	59.08	5.00e-142	498.00
IUUC-Sly-111722	Solanum lycopersicum	67.70	4.00e-148	518.00
IUUC-Stu-112912	Solanum tuberosum	66.32	2.00e-147	515.00
IUUC-Sar-113340	Sorex araneus	42.48	7.00e-76	278.00
IUUC-Sbi-114477	Sorghum bicolor	49.36	5.00e-142	498.00
IUUC-Sre-114924	Sporisorium reilianum	39.77	6.00e-65	241.00
IUUC-Ssc-116022	Sus scrofa	36.51	3.00e-71	263.00
IUUC-Tgu-117149	Taeniopygia guttata	37.50	3.00e-72	266.00
IUUC-Tru-118391	Takifugu rubripes	39.59	4.00e-79	289.00
IUUC-Tsy-118974	Tarsius syrichta	42.81	9.00e-77	281.00
IUUC-Tni-120064	Tetraodon nigroviridis	40.10	4.00e-79	289.00
IUUC-Tca-120936	Theobroma cacao	68.07	2.00e-174	605.00
IUUC-Tae-124495	Triticum aestivum	47.54	5.00e-143	501.00
IUUC-Tur-126014	Triticum urartu	63.96	1.00e-120	427.00
IUUC-Ttr-129259	Tursiops truncatus	33.33	5.00e-56	212.00
IUUC-Uma-129416	Ustilago maydis	41.13	2.00e-66	246.00
IUUC-Vvi-131535	Vitis vinifera	71.54	2.00e-176	612.00
IUUC-Xtr-132544	Xenopus tropicalis	42.72	1.00e-76	280.00
IUUC-Xma-133735	Xiphophorus maculatus	38.82	2.00e-78	286.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence