iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013231

UUCD1 version

UUC-BoT-00683

Ensembl Protein ID

ENSBTAP00000024513.5

UniProt Accession

A3KMV3; E1BKA7; A3KMV3_BOVIN

Genbank Protein ID

AAI33289.1; AFK29262.1

Protein Name

E3 ligase WWP2; WWP2 protein

Genbank Nucleotide ID

DAAA02046708; JN712753

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000018421.5	ENSBTAT00000024513.5	ENSBTAP00000024513.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-135	451.6	537	869

Active Site

Position(s)	Description	Evidence
838	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 625  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 710
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 711  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDLSDWQKHTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf el     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyA+eet+gF++
   Q: 799  TGTCRLPVGGFTELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAVEETEGFGQ 869
           *********************************************************************96 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MASASSSRAG VALPFEKSQL ILKVVSAKPK VHSRQPRINS FVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS INLSSVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGTTGGGC GCCGCTTCTG TGGCCGCTGC AGGTAGCCAG CGCGGGCACT GGGGACGCAG 60
CTGGCGGGTG GGGGCGCAGG GAAGTCCGGG GGCGGCAGGC GGCGCGGGGT GGGCCGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

KEGG

bta:512457

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	95.87	0.00e+00	1640.00
IUUC-Apl-003912	Anas platyrhynchos	76.27	0.00e+00	1228.00
IUUC-Aca-004291	Anolis carolinensis	80.32	0.00e+00	1430.00
IUUC-Cja-019455	Callithrix jacchus	94.71	0.00e+00	1656.00
IUUC-Cfa-021017	Canis familiaris	96.21	0.00e+00	1625.00
IUUC-Cpo-021988	Cavia porcellus	94.48	0.00e+00	1644.00
IUUC-Csa-023549	Chlorocebus sabaeus	94.83	0.00e+00	1666.00
IUUC-Dre-028513	Danio rerio	91.59	0.00e+00	1132.00
IUUC-Dno-028976	Dasypus novemcinctus	95.06	0.00e+00	1645.00
IUUC-Dor-030176	Dipodomys ordii	92.20	0.00e+00	1488.00
IUUC-Eca-033949	Equus caballus	96.44	0.00e+00	1656.00
IUUC-Eeu-034529	Erinaceus europaeus	88.09	0.00e+00	1373.00
IUUC-Fca-036236	Felis catus	95.86	0.00e+00	1658.00
IUUC-Fal-036948	Ficedula albicollis	95.47	0.00e+00	1168.00
IUUC-Gmo-038842	Gadus morhua	89.42	0.00e+00	1071.00
IUUC-Gga-040617	Gallus gallus	79.69	0.00e+00	1414.00
IUUC-Gac-041338	Gasterosteus aculeatus	69.61	0.00e+00	1243.00
IUUC-Ggo-045278	Gorilla gorilla	95.29	0.00e+00	1671.00
IUUC-Hsa-046148	Homo sapiens	95.29	0.00e+00	1673.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	98.13	0.00e+00	1118.00
IUUC-Lch-050663	Latimeria chalumnae	78.37	0.00e+00	1381.00
IUUC-Loc-052604	Lepisosteus oculatus	75.57	0.00e+00	1304.00
IUUC-Laf-053944	Loxodonta africana	94.94	0.00e+00	1662.00
IUUC-Mcc-055655	Macaca mulatta	94.94	0.00e+00	1667.00
IUUC-Meu-055953	Macropus eugenii	79.82	0.00e+00	1362.00
IUUC-Mga-060190	Meleagris gallopavo	79.93	0.00e+00	1416.00
IUUC-Mmr-060896	Microcebus murinus	94.91	0.00e+00	1615.00
IUUC-Mdo-062536	Monodelphis domestica	90.48	0.00e+00	1583.00
IUUC-Mmu-064017	Mus musculus	94.25	0.00e+00	1611.00
IUUC-Mpu-066608	Mustela putorius furo	93.46	0.00e+00	1573.00
IUUC-Mlu-067623	Myotis lucifugus	92.77	0.00e+00	1589.00
IUUC-Nle-069496	Nomascus leucogenys	93.23	0.00e+00	1624.00
IUUC-Opr-071054	Ochotona princeps	83.86	0.00e+00	1415.00
IUUC-Ont-071279	Oreochromis niloticus	73.85	0.00e+00	1269.00
IUUC-Oan-073512	Ornithorhynchus anatinus	88.18	0.00e+00	1488.00
IUUC-Ocu-074271	Oryctolagus cuniculus	95.22	0.00e+00	1610.00
IUUC-Ola-087237	Oryzias latipes	69.64	0.00e+00	1222.00
IUUC-Oga-088164	Otolemur garnettii	95.98	0.00e+00	1664.00
IUUC-Oar-089698	Ovis aries	99.54	0.00e+00	1654.00
IUUC-Ptr-091306	Pan troglodytes	94.02	0.00e+00	1640.00
IUUC-Pan-092814	Papio anubis	91.28	0.00e+00	1576.00
IUUC-Pfo-096709	Poecilia formosa	72.17	0.00e+00	1275.00
IUUC-Pab-098494	Pongo abelii	90.05	0.00e+00	1573.00
IUUC-Pca-100596	Procavia capensis	83.10	0.00e+00	1362.00
IUUC-Pva-103154	Pteropus vampyrus	90.84	0.00e+00	1546.00
IUUC-Rno-104954	Rattus norvegicus	94.06	0.00e+00	1389.00
IUUC-Sha-106781	Sarcophilus harrisii	90.94	0.00e+00	1626.00
IUUC-Ssc-116307	Sus scrofa	84.13	0.00e+00	1461.00
IUUC-Tgu-116530	Taeniopygia guttata	76.11	0.00e+00	1184.00
IUUC-Tru-118287	Takifugu rubripes	89.46	0.00e+00	1064.00
IUUC-Tsy-119097	Tarsius syrichta	81.95	0.00e+00	1214.00
IUUC-Tni-120801	Tetraodon nigroviridis	68.72	0.00e+00	1133.00
IUUC-Tbe-127793	Tupaia belangeri	82.99	0.00e+00	1398.00
IUUC-Ttr-128275	Tursiops truncatus	92.64	0.00e+00	1564.00
IUUC-Xtr-132866	Xenopus tropicalis	89.25	0.00e+00	1125.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence