iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091306

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AACZ03104752

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000008288.5	ENSPTRT00000045375.4	ENSPTRP00000044693.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-122	408.8	537	859

Active Site

Position(s)	Description	Evidence
828	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+g e+i+V           +++
   Q: 625  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGRESIRVL----------LTD 700
           ***********************************99...9**********************************5..........9** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 701  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 788
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+l+ekLl+Aieet+gF++
   Q: 789  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLFAIEETEGFGQ 859
           *********************************************************************96 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCTTCACG GTGATGATAT GGCATCTGCC AGCTCTAGCC GGGCAGGAGT GGCCCTGCCT 60
TTTGAGAAGT CTCAGCTCAC TTTGAAAGGT GAGTGGCACT GTATAATGTC TTCATCTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	94.95	0.00e+00	1612.00
IUUC-Apl-003912	Anas platyrhynchos	75.72	0.00e+00	1213.00
IUUC-Aca-004291	Anolis carolinensis	80.34	0.00e+00	1413.00
IUUC-Bta-013231	Bos taurus	94.02	0.00e+00	1568.00
IUUC-Cja-019455	Callithrix jacchus	97.01	0.00e+00	1687.00
IUUC-Cfa-021017	Canis familiaris	95.29	0.00e+00	1600.00
IUUC-Cpo-021988	Cavia porcellus	94.71	0.00e+00	1644.00
IUUC-Csa-023549	Chlorocebus sabaeus	97.24	0.00e+00	1701.00
IUUC-Dre-028513	Danio rerio	90.89	0.00e+00	1114.00
IUUC-Dno-028976	Dasypus novemcinctus	94.37	0.00e+00	1639.00
IUUC-Dor-030176	Dipodomys ordii	91.49	0.00e+00	1479.00
IUUC-Eca-033949	Equus caballus	95.06	0.00e+00	1619.00
IUUC-Eeu-034529	Erinaceus europaeus	86.81	0.00e+00	1340.00
IUUC-Fca-036236	Felis catus	94.83	0.00e+00	1647.00
IUUC-Fal-036948	Ficedula albicollis	77.54	0.00e+00	1305.00
IUUC-Gmo-038842	Gadus morhua	87.83	0.00e+00	1058.00
IUUC-Gga-040617	Gallus gallus	79.10	0.00e+00	1407.00
IUUC-Gac-041338	Gasterosteus aculeatus	69.05	0.00e+00	1235.00
IUUC-Ggo-045278	Gorilla gorilla	98.51	0.00e+00	1719.00
IUUC-Hsa-046148	Homo sapiens	98.51	0.00e+00	1719.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	95.89	0.00e+00	1089.00
IUUC-Lch-050663	Latimeria chalumnae	77.01	0.00e+00	1360.00
IUUC-Loc-052604	Lepisosteus oculatus	74.18	0.00e+00	1293.00
IUUC-Laf-053944	Loxodonta africana	94.83	0.00e+00	1637.00
IUUC-Mcc-055655	Macaca mulatta	97.47	0.00e+00	1701.00
IUUC-Meu-055953	Macropus eugenii	78.34	0.00e+00	1360.00
IUUC-Mga-060190	Meleagris gallopavo	79.46	0.00e+00	1404.00
IUUC-Mmr-060896	Microcebus murinus	95.84	0.00e+00	1618.00
IUUC-Mdo-062536	Monodelphis domestica	89.79	0.00e+00	1577.00
IUUC-Mmu-064017	Mus musculus	94.71	0.00e+00	1627.00
IUUC-Mpu-066608	Mustela putorius furo	92.78	0.00e+00	1560.00
IUUC-Mlu-067623	Myotis lucifugus	91.62	0.00e+00	1563.00
IUUC-Nle-069496	Nomascus leucogenys	95.98	0.00e+00	1662.00
IUUC-Opr-071054	Ochotona princeps	83.16	0.00e+00	1398.00
IUUC-Ont-071279	Oreochromis niloticus	73.10	0.00e+00	1270.00
IUUC-Oan-073512	Ornithorhynchus anatinus	87.14	0.00e+00	1468.00
IUUC-Ocu-074271	Oryctolagus cuniculus	94.28	0.00e+00	1595.00
IUUC-Ola-087237	Oryzias latipes	84.47	0.00e+00	1039.00
IUUC-Oga-088164	Otolemur garnettii	95.63	0.00e+00	1657.00
IUUC-Oar-089698	Ovis aries	94.37	0.00e+00	1578.00
IUUC-Pan-092814	Papio anubis	93.58	0.00e+00	1606.00
IUUC-Pfo-096709	Poecilia formosa	89.16	0.00e+00	1072.00
IUUC-Pab-098494	Pongo abelii	92.45	0.00e+00	1615.00
IUUC-Pca-100596	Procavia capensis	82.62	0.00e+00	1350.00
IUUC-Pva-103154	Pteropus vampyrus	90.37	0.00e+00	1541.00
IUUC-Rno-104954	Rattus norvegicus	93.92	0.00e+00	1385.00
IUUC-Sha-106781	Sarcophilus harrisii	90.14	0.00e+00	1621.00
IUUC-Ssc-116307	Sus scrofa	82.96	0.00e+00	1412.00
IUUC-Tgu-116530	Taeniopygia guttata	74.88	0.00e+00	1164.00
IUUC-Tru-118287	Takifugu rubripes	88.22	0.00e+00	1056.00
IUUC-Tsy-119097	Tarsius syrichta	82.84	0.00e+00	1215.00
IUUC-Tni-120801	Tetraodon nigroviridis	67.04	0.00e+00	1126.00
IUUC-Tbe-127793	Tupaia belangeri	83.68	0.00e+00	1417.00
IUUC-Ttr-128275	Tursiops truncatus	90.11	0.00e+00	1519.00
IUUC-Xtr-132866	Xenopus tropicalis	81.16	0.00e+00	1105.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence