iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBAN	26.51	5.00e-04	43.10	IUUC-Mmu-063409

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Drosophila melanogaster

Functional Description
(View)

Essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for NF-kappa-B (Rel) activation. Required for antibacterial immune response.

Protein Sequence
(Fasta)

MSDEESFVIL GSSPCSSLMP DSSLRSDVCG NAQEAKETVA STSTQPPTVN CIPVSITASQ 60
QQHKSLDSGS SQQQSLATSF IMGEIQSDVL KNSVYSQFPS LCSLQGSAEE VVKLQNMMTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCACACTGGT CTAAGTTGTT TGGTAAATTA GTTAAAAGTA AATATTACTC CGAAAACAAT 60
TTTATTTCCT TAAAGCTTGT CAGCAAAGCA AAACGAGATA AGGAACGCAG TAGTATATAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032419--CC2-LZ_dom
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0050829--P:defense response to Gram-negative bacterium
GO:0051607--P:defense response to virus
GO:0006955--P:immune response
GO:0045087--P:innate immune response
GO:2000647--P:negative regulation of stem cell proliferation
GO:0061057--P:peptidoglycan recognition protein signaling pathway
GO:0006963--P:positive regulation of antibacterial peptide biosynthetic process
GO:0006964--P:positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
GO:0002230--P:positive regulation of defense response to virus by host
GO:0045089--P:positive regulation of innate immune response
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030163--P:protein catabolic process
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0008063--P:Toll signaling pathway

KEGG

dme:Dmel_CG16910

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003812	Anas platyrhynchos	30.77	5.00e-05	42.00
IUUC-Aca-004653	Anolis carolinensis	50.00	9.50e-01	26.90
IUUC-Ame-011116	Astyanax mexicanus	28.38	2.00e-05	43.10
IUUC-Cja-018954	Callithrix jacchus	25.23	4.40e-01	28.50
IUUC-Cfa-020778	Canis familiaris	30.37	8.00e-05	40.80
IUUC-Cpo-022327	Cavia porcellus	29.01	1.20e-01	30.00
IUUC-Csa-023662	Chlorocebus sabaeus	27.34	3.00e-04	39.30
IUUC-Dre-027720	Danio rerio	28.16	8.00e-06	44.70
IUUC-Dno-029976	Dasypus novemcinctus	28.70	4.90e-02	30.40
IUUC-Dor-030890	Dipodomys ordii	27.50	1.00e-04	40.40
IUUC-Ete-032568	Echinops telfairi	31.79	1.00e-05	43.90
IUUC-Eca-033895	Equus caballus	29.10	2.40e-01	29.30
IUUC-Eeu-034478	Erinaceus europaeus	45.83	1.90e+00	26.20
IUUC-Fca-035852	Felis catus	27.97	7.00e-04	38.10
IUUC-Fal-036862	Ficedula albicollis	28.06	5.00e-05	42.00
IUUC-Gmo-038735	Gadus morhua	28.67	4.00e-05	42.00
IUUC-Gga-040939	Gallus gallus	29.50	5.00e-05	42.00
IUUC-Gac-041580	Gasterosteus aculeatus	26.24	6.00e-04	38.50
IUUC-Ggo-045478	Gorilla gorilla	25.23	1.10e+00	27.30
IUUC-Hsa-046243	Homo sapiens	25.23	1.20e+00	27.30
IUUC-Lch-049880	Latimeria chalumnae	27.78	1.00e-06	44.70
IUUC-Loc-052185	Lepisosteus oculatus	26.91	2.00e-05	43.50
IUUC-Laf-054079	Loxodonta africana	28.29	7.00e-04	38.10
IUUC-Mcc-055674	Macaca mulatta	26.56	1.00e-03	37.70
IUUC-Meu-056769	Macropus eugenii	30.05	2.00e-06	46.60
IUUC-Mga-060203	Meleagris gallopavo	30.22	5.00e-05	42.00
IUUC-Mmr-061492	Microcebus murinus	27.27	2.00e-04	39.70
IUUC-Mdo-063051	Monodelphis domestica	27.75	2.00e-06	47.00
IUUC-Mmu-063409	Mus musculus	26.51	3.00e-07	49.70
IUUC-Mlu-067400	Myotis lucifugus	27.07	2.00e-03	38.90
IUUC-Opr-071049	Ochotona princeps	27.56	9.00e-04	37.70
IUUC-Ont-071915	Oreochromis niloticus	28.05	5.00e-06	45.10
IUUC-Oan-072965	Ornithorhynchus anatinus	27.01	4.00e-05	42.40
IUUC-Ocu-074029	Oryctolagus cuniculus	27.56	4.00e-04	38.50
IUUC-Ola-087019	Oryzias latipes	29.23	2.00e-04	39.70
IUUC-Oga-088613	Otolemur garnettii	26.85	7.00e-05	41.60
IUUC-Ptr-090498	Pan troglodytes	25.23	8.70e-01	27.70
IUUC-Pan-092178	Papio anubis	26.56	1.00e-03	37.40
IUUC-Psi-093214	Pelodiscus sinensis	28.28	4.00e-05	42.40
IUUC-Pfo-096901	Poecilia formosa	25.15	6.00e-04	38.10
IUUC-Pab-097707	Pongo abelii	25.23	9.60e-01	27.30
IUUC-Pca-100853	Procavia capensis	26.45	1.00e-03	37.40
IUUC-Rno-105812	Rattus norvegicus	27.01	8.00e-06	44.70
IUUC-Sha-107225	Sarcophilus harrisii	27.45	6.00e-08	50.80
IUUC-Sar-113736	Sorex araneus	29.73	4.80e-02	32.00
IUUC-Ssc-115652	Sus scrofa	22.27	1.20e-01	30.80
IUUC-Tgu-116924	Taeniopygia guttata	28.87	5.00e-05	42.00
IUUC-Tru-117695	Takifugu rubripes	24.38	1.00e-05	44.30
IUUC-Tni-120645	Tetraodon nigroviridis	27.78	2.00e-05	43.10
IUUC-Tbe-127949	Tupaia belangeri	45.83	1.10e+00	27.30
IUUC-Ttr-129244	Tursiops truncatus	29.47	2.00e-04	40.40
IUUC-Vpa-130313	Vicugna pacos	31.25	4.00e-06	45.80
IUUC-Xtr-132115	Xenopus tropicalis	30.61	6.00e-06	45.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence