iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012963

Ensembl Protein ID

ENSBTAP00000045084.3

UniProt Accession

E1B7X9; SMRCD_BOVIN

Genbank Protein ID

ENSBTAP00000045084

Protein Name

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

Genbank Nucleotide ID

DAAA02016925

Gene Name

SMARCAD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000017061.5	ENSBTAT00000047936.3	ENSBTAP00000045084.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	44.84	1.00e-124	442.00	IUUC-Sce-106399

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity).

Protein Sequence
(Fasta)

MNLFNLDRFR FEKRNKIEEA PEATPQPSQP GPSSPISLSA EEENAEGEVS RAGTPDSDVT 60
EKTEDSSVPE TPENDRKASI SYFKNQRGIQ YIDLSSDSED VVSPNCSSTV QEKKFNKDTV 120

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Nucleotide Sequence
(Fasta)

ATGAATCTTT TCAACCTGGA CCGTTTTCGC TTTGAGAAAA GAAATAAGAT TGAGGAAGCG 60
CCCGAAGCAA CCCCTCAACC CTCCCAGCCT GGCCCTTCTT CACCAATTTC TCTTAGTGCT 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR003892--CUE
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N

PROSITE

PS51140--CUE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER

Pfam

PF00271--Helicase_C
PF00176--SNF2_N

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0000792--C:heterochromatin
GO:0043596--C:nuclear replication fork
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0051304--P:chromosome separation
GO:0000729--P:DNA double-strand break processing
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0000018--P:regulation of DNA recombination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000567	Aegilops tauschii	37.52	5.00e-99	355.00
IUUC-Aml-002063	Ailuropoda melanoleuca	95.14	0.00e+00	1896.00
IUUC-Atr-003078	Amborella trichopoda	36.06	1.00e-105	377.00
IUUC-Apl-003860	Anas platyrhynchos	70.44	0.00e+00	1340.00
IUUC-Aca-004485	Anolis carolinensis	68.57	0.00e+00	1364.00
IUUC-Aly-006561	Arabidopsis lyrata	37.18	1.00e-105	377.00
IUUC-Ath-006832	Arabidopsis thaliana	37.22	2.00e-106	380.00
IUUC-Ago-007758	Ashbya gossypii	45.49	7.00e-134	471.00
IUUC-Acl-008226	Aspergillus clavatus	44.69	3.00e-133	469.00
IUUC-Afl-008556	Aspergillus flavus	45.96	3.00e-131	462.00
IUUC-Afu-008799	Aspergillus fumigatus	44.51	5.00e-133	469.00
IUUC-Ani-009127	Aspergillus nidulans	45.75	6.00e-131	462.00
IUUC-Ang-009676	Aspergillus niger	44.36	5.00e-132	465.00
IUUC-Aor-010184	Aspergillus oryzae	45.08	3.00e-132	466.00
IUUC-Ate-010559	Aspergillus terreus	37.82	4.00e-130	459.00
IUUC-Ame-011933	Astyanax mexicanus	59.90	0.00e+00	885.00
IUUC-Bci-013670	Botrytis cinerea	41.52	9.00e-119	421.00
IUUC-Bdi-014286	Brachypodium distachyon	37.48	2.00e-101	363.00
IUUC-Bol-016519	Brassica oleracea	39.53	2.00e-106	380.00
IUUC-Bra-017239	Brassica rapa	39.53	3.00e-106	379.00
IUUC-Cel-018253	Caenorhabditis elegans	43.19	4.00e-140	492.00
IUUC-Cja-019465	Callithrix jacchus	93.52	0.00e+00	1870.00
IUUC-Cfa-020637	Canis familiaris	94.36	0.00e+00	1923.00
IUUC-Cpo-021822	Cavia porcellus	91.31	0.00e+00	1717.00
IUUC-Csa-023315	Chlorocebus sabaeus	97.27	0.00e+00	1645.00
IUUC-Cin-025444	Ciona intestinalis	49.85	3.00e-175	608.00
IUUC-Cgl-026383	Colletotrichum gloeosporioides	40.22	2.00e-105	377.00
IUUC-Cne-027090	Cryptococcus neoformans	35.94	7.00e-114	405.00
IUUC-Dre-028385	Danio rerio	58.93	0.00e+00	867.00
IUUC-Dno-028932	Dasypus novemcinctus	93.10	0.00e+00	1886.00
IUUC-Dse-031394	Dothistroma septosporum	36.75	4.00e-104	372.00
IUUC-Dme-031640	Drosophila melanogaster	45.23	5.00e-156	545.00
IUUC-Eca-033276	Equus caballus	94.96	0.00e+00	1951.00
IUUC-Fca-035936	Felis catus	93.68	0.00e+00	1894.00
IUUC-Fal-037636	Ficedula albicollis	65.55	0.00e+00	1293.00
IUUC-Fso-038229	Fusarium solani	35.55	2.00e-111	397.00
IUUC-Gmo-039654	Gadus morhua	56.76	0.00e+00	891.00
IUUC-Ggr-039922	Gaeumannomyces graminis	33.29	6.00e-94	338.00
IUUC-Gga-040646	Gallus gallus	65.15	0.00e+00	1345.00
IUUC-Gac-042320	Gasterosteus aculeatus	65.89	0.00e+00	802.00
IUUC-Gma-042832	Glycine max	39.12	5.00e-106	378.00
IUUC-Ggo-044875	Gorilla gorilla	86.60	0.00e+00	1746.00
IUUC-Hsa-046992	Homo sapiens	93.69	0.00e+00	1892.00
IUUC-Hvu-047408	Hordeum vulgare	37.84	6.00e-101	362.00
IUUC-Itr-047881	Ictidomys tridecemlineatus	97.83	0.00e+00	1106.00
IUUC-Kpa-049212	Komagataella pastoris	43.03	2.00e-127	450.00
IUUC-Lpe-050987	Leersia perrieri	35.02	3.00e-100	359.00
IUUC-Loc-052272	Lepisosteus oculatus	53.52	0.00e+00	995.00
IUUC-Lma-053118	Leptosphaeria maculans	42.29	8.00e-122	432.00
IUUC-Laf-053436	Loxodonta africana	91.63	0.00e+00	1837.00
IUUC-Mcc-055209	Macaca mulatta	97.07	0.00e+00	1664.00
IUUC-Mor-056994	Magnaporthe oryzae	34.65	7.00e-96	345.00
IUUC-Mpo-057305	Magnaporthe poae	33.85	2.00e-98	353.00
IUUC-Mtr-058432	Medicago truncatula	39.60	7.00e-105	374.00
IUUC-Mla-058972	Melampsora laricipopulina	38.95	3.00e-123	435.00
IUUC-Mga-059572	Meleagris gallopavo	63.51	0.00e+00	1195.00
IUUC-Mvi-060209	Microbotryum violaceum	40.09	5.00e-140	492.00
IUUC-Mmr-061416	Microcebus murinus	92.28	0.00e+00	1121.00
IUUC-Mdo-062869	Monodelphis domestica	79.29	0.00e+00	1595.00
IUUC-Mmu-064272	Mus musculus	88.63	0.00e+00	1637.00
IUUC-Mac-064963	Musa acuminata	34.23	5.00e-94	338.00
IUUC-Mpu-065755	Mustela putorius furo	95.14	0.00e+00	1933.00
IUUC-Mlu-067604	Myotis lucifugus	90.39	0.00e+00	1826.00
IUUC-Nfi-068310	Neosartorya fischeri	44.32	3.00e-132	466.00
IUUC-Ncr-068841	Neurospora crassa	34.08	4.00e-109	389.00
IUUC-Nle-069227	Nomascus leucogenys	93.79	0.00e+00	1894.00
IUUC-Opr-071088	Ochotona princeps	85.99	0.00e+00	1337.00
IUUC-Ont-072291	Oreochromis niloticus	65.99	0.00e+00	826.00
IUUC-Oan-073460	Ornithorhynchus anatinus	84.54	0.00e+00	1370.00
IUUC-Ocu-074811	Oryctolagus cuniculus	92.90	0.00e+00	1830.00
IUUC-Oba-075463	Oryza barthii	38.08	4.00e-100	358.00
IUUC-Obr-076342	Oryza brachyantha	38.08	4.00e-103	369.00
IUUC-Ogu-078837	Oryza glumaepatula	38.08	2.00e-100	360.00
IUUC-Oin-079623	Oryza indica	38.08	1.00e-100	361.00
IUUC-Ome-081105	Oryza meridionalis	38.08	8.00e-101	361.00
IUUC-Oni-082598	Oryza nivara	38.08	1.00e-100	361.00
IUUC-Opu-084040	Oryza punctata	38.08	1.00e-100	361.00
IUUC-Oru-084219	Oryza rufipogon	38.08	1.00e-100	361.00
IUUC-Osa-085461	Oryza sativa	38.08	1.00e-100	361.00
IUUC-Ola-087307	Oryzias latipes	66.30	0.00e+00	794.00
IUUC-Olu-087812	Ostreococcus lucimarinus	39.46	2.00e-100	359.00
IUUC-Oga-089064	Otolemur garnettii	92.43	0.00e+00	1853.00
IUUC-Oar-090054	Ovis aries	97.08	0.00e+00	1935.00
IUUC-Ptr-091228	Pan troglodytes	93.97	0.00e+00	1899.00
IUUC-Pan-092769	Papio anubis	93.12	0.00e+00	1761.00
IUUC-Psi-093202	Pelodiscus sinensis	70.68	0.00e+00	1360.00
IUUC-Pma-094725	Petromyzon marinus	45.83	0.00e+00	851.00
IUUC-Pno-095130	Phaeosphaeria nodorum	34.93	2.00e-112	400.00
IUUC-Ppa-095559	Physcomitrella patens	40.98	3.00e-109	389.00
IUUC-Pfo-096546	Poecilia formosa	66.46	0.00e+00	837.00
IUUC-Pab-097698	Pongo abelii	93.79	0.00e+00	1877.00
IUUC-Pop-099986	Populus trichocarpa	39.36	2.00e-106	379.00
IUUC-Ppe-101649	Prunus persica	39.31	6.00e-104	371.00
IUUC-Pva-102138	Pteropus vampyrus	92.43	0.00e+00	1839.00
IUUC-Pgr-103272	Puccinia graminis	35.56	6.00e-121	428.00
IUUC-Ptt-103880	Puccinia triticina	35.77	9.00e-129	454.00
IUUC-Pte-104260	Pyrenophora teres	43.10	4.00e-118	419.00
IUUC-Pyt-104532	Pyrenophora triticirepentis	33.46	5.00e-76	279.00
IUUC-Rno-105903	Rattus norvegicus	89.60	0.00e+00	1691.00
IUUC-Sce-106399	Saccharomyces cerevisiae	44.84	8.00e-127	448.00
IUUC-Sha-106783	Sarcophilus harrisii	79.58	0.00e+00	1563.00
IUUC-Sja-107887	Schizosaccharomyces japonicus	41.16	3.00e-143	503.00
IUUC-Spo-108154	Schizosaccharomyces pombe	42.64	2.00e-148	520.00
IUUC-Smo-108759	Selaginella moellendorffii	40.15	2.00e-105	375.00
IUUC-Sit-110023	Setaria italica	37.52	8.00e-101	361.00
IUUC-Sly-111423	Solanum lycopersicum	39.82	2.00e-105	376.00
IUUC-Sbi-114688	Sorghum bicolor	37.55	2.00e-102	366.00
IUUC-Sre-114983	Sporisorium reilianum	36.04	1.00e-111	398.00
IUUC-Ssc-116030	Sus scrofa	94.98	0.00e+00	1941.00
IUUC-Tgu-117451	Taeniopygia guttata	77.42	0.00e+00	1192.00
IUUC-Tru-118600	Takifugu rubripes	66.15	0.00e+00	795.00
IUUC-Tsy-119130	Tarsius syrichta	83.40	0.00e+00	1550.00
IUUC-Tni-119758	Tetraodon nigroviridis	57.31	0.00e+00	875.00
IUUC-Tca-121797	Theobroma cacao	39.63	3.00e-106	379.00
IUUC-Tre-121883	Trichoderma reesei	40.37	3.00e-102	366.00
IUUC-Tvi-122333	Trichoderma virens	40.37	2.00e-110	393.00
IUUC-Tae-122848	Triticum aestivum	38.16	3.00e-99	356.00
IUUC-Tur-126594	Triticum urartu	38.16	8.00e-99	354.00
IUUC-Tme-127106	Tuber melanosporum	42.15	2.00e-123	437.00
IUUC-Tbe-127911	Tupaia belangeri	96.83	0.00e+00	994.00
IUUC-Ttr-128597	Tursiops truncatus	94.85	0.00e+00	1853.00
IUUC-Uma-129321	Ustilago maydis	36.00	9.00e-111	395.00
IUUC-Vpa-130686	Vicugna pacos	87.29	0.00e+00	1678.00
IUUC-Vvi-131046	Vitis vinifera	39.19	3.00e-106	379.00
IUUC-Xtr-132740	Xenopus tropicalis	65.82	0.00e+00	1124.00
IUUC-Xma-134260	Xiphophorus maculatus	66.15	0.00e+00	828.00
IUUC-Yli-134634	Yarrowia lipolytica	40.54	3.00e-138	486.00
IUUC-Zma-135493	Zea mays	37.04	2.00e-101	364.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence