iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000009476.1	ENSONIT00000011915.1	ENSONIP00000011906.1
ENSONIG00000009476.1	ENSONIT00000011916.1	ENSONIP00000011907.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.50e-60	203.7	154	639

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +G++N+gNtC++ +v+Q+L+++p +r+l+l+     k  ek++  + ++++ +++++l+ lf+ ++ s+++ v+p++ ++ l+++ +  
   Q: 154  VGIRNVGNTCWFSAVIQSLFHLPVFRRLVLNyhlseKILEKCKSHS-DKRNIAFMQELRCLFALMVGSTRRFVDPSAAVELLRDAFRT- 240
           69*****************************998887778887654.79999*******************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            + +qqD++Ef + lld le++++                     + ++ + k+++++++lF g++ ++    + +++    e+f +++
   Q: 241  -NEAQQDVSEFSHKLLDWLEDAFQL------------------AASGKNAEDKQHNPMVQLFYGTFVTE--RRHEGKTVYNIEQFGQYP 308
           .89********************22..................2346789999*************965..5567888999******** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e+e+e+       + ++++++ ++ ++kklP+vL+++L+Rf+f+ + +++eki+kk+efp+ + ++
   Q: 309  LQVNGFN-----NLDECLEGAMVEKEIES------VHSEHHVTSGRERWFKKLPPVLTFELSRFEFNTQLGRPEKIHKKLEFPQIIYMD 386
           *******.....9********99999995......4556678899******************************************** PP
   S: 263  pfcts.............................peekqke................................................ 274
           +++++                             +     +                                                
   Q: 387  RYLHKnieqtherrgevkklkeqlavlqqklecyK-----Nygsgptkypladmlqfvlefattkptsvspaedsrqaassptppsapl 470
           *****666666555555555555555555555550.....0555555555555555555555555555555555555666666666666 PP
   S: 275  ......................................................................................... 274
                                                                                                    
   Q: 471  seaiakessdpgesvsseslgssvsscqrtpiykpftqcrqpidcpphpaphsiteeelhfaktclqrwrtevendinelkasidrltq 559
           66666666666777777777777777777777777777777778888888888888888888888888888888888888899999999 PP
   S: 275  ............kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                       +  Y+L+av+vH+G++s GHY+ay+++++++ Wl+++D +Vte++++e ++++      ++aY+l+Y 
   Q: 560  tlegmysdnslcQAPYRLHAVLVHEGQASAGHYWAYIYDHTNQrWLKYNDISVTESSWDELERDSFggmtnASAYCLMYI 639
           9999999999999**************************88888*******************77799***********6 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MFSSAMRADQ SENGENSTNS QSEMLISQLR EITGIQDQQI LYRALNVSQG DIGHAVGLLT 60
TQTAELQDPG EPQESGTSGE AWEGQKGLPK DELQTAIELS LQESHKAQEE EREFHRALEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTCGT CTGCAATGAG AGCCGATCAG TCTGAAAATG GAGAAAACTC AACCAACTCG 60
GTGAGAGCTC AGGATGATGG AGCTGCTATT AACACAATAA GTGGCATGTT TGTGACTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	55.30	0.00e+00	744.00
IUUC-Ang-009577	Aspergillus niger	35.35	4.00e-11	64.30
IUUC-Ame-011910	Astyanax mexicanus	65.31	6.00e-173	602.00
IUUC-Bgr-011993	Blumeria graminis	39.19	2.00e-12	68.90
IUUC-Bta-013377	Bos taurus	52.90	0.00e+00	726.00
IUUC-Cel-018346	Caenorhabditis elegans	28.44	3.00e-29	124.00
IUUC-Cho-024717	Choloepus hoffmanni	53.19	6.00e-99	355.00
IUUC-Cme-027167	Cyanidioschyzon merolae	32.58	4.00e-16	80.90
IUUC-Dre-028105	Danio rerio	73.10	0.00e+00	1003.00
IUUC-Dor-030955	Dipodomys ordii	54.88	0.00e+00	693.00
IUUC-Ete-032828	Echinops telfairi	55.23	2.00e-132	466.00
IUUC-Eca-034300	Equus caballus	55.87	0.00e+00	707.00
IUUC-Eeu-034458	Erinaceus europaeus	55.93	0.00e+00	694.00
IUUC-Fca-035753	Felis catus	56.99	0.00e+00	752.00
IUUC-Gmo-039593	Gadus morhua	75.25	0.00e+00	1028.00
IUUC-Gac-041867	Gasterosteus aculeatus	87.55	0.00e+00	1229.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	57.72	3.00e-102	366.00
IUUC-Kpa-049349	Komagataella pastoris	29.34	6.00e-10	60.50
IUUC-Loc-052636	Lepisosteus oculatus	68.62	0.00e+00	955.00
IUUC-Mmu-063870	Mus musculus	55.25	0.00e+00	745.00
IUUC-Mpu-066454	Mustela putorius furo	56.70	0.00e+00	738.00
IUUC-Opr-070888	Ochotona princeps	58.99	3.00e-97	350.00
IUUC-Ola-086393	Oryzias latipes	81.29	0.00e+00	1145.00
IUUC-Oga-088618	Otolemur garnettii	56.80	0.00e+00	731.00
IUUC-Psi-093422	Pelodiscus sinensis	53.65	0.00e+00	726.00
IUUC-Pma-094250	Petromyzon marinus	47.04	5.00e-71	261.00
IUUC-Pno-095093	Phaeosphaeria nodorum	33.64	7.00e-13	70.10
IUUC-Pfo-096466	Poecilia formosa	83.57	0.00e+00	2003.00
IUUC-Pva-102226	Pteropus vampyrus	53.27	2.00e-176	613.00
IUUC-Sha-107489	Sarcophilus harrisii	55.82	0.00e+00	748.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	35.80	1.00e-09	59.70
IUUC-Tru-117807	Takifugu rubripes	81.07	0.00e+00	1144.00
IUUC-Tni-119983	Tetraodon nigroviridis	75.84	0.00e+00	1126.00
IUUC-Ttr-128887	Tursiops truncatus	48.78	0.00e+00	628.00
IUUC-Uma-129338	Ustilago maydis	23.93	2.00e-12	68.90
IUUC-Xma-133995	Xiphophorus maculatus	83.07	0.00e+00	1942.00
IUUC-Yli-134560	Yarrowia lipolytica	29.63	4.00e-11	64.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence