iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118324

Ensembl Protein ID

ENSTRUP00000037835.1

UniProt Accession

H2ULL4; H2ULL4_TAKRU

Protein Name

Non-specific protein-tyrosine kinase

Gene Name

abl1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000014808.1	ENSTRUT00000037971.1	ENSTRUP00000037835.1
ENSTRUG00000014808.1	ENSTRUT00000037972.1	ENSTRUP00000037836.1
ENSTRUG00000014808.1	ENSTRUT00000037973.1	ENSTRUP00000037837.1
ENSTRUG00000014808.1	ENSTRUT00000037974.1	ENSTRUP00000037838.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.50e-14	52.9	437	494

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 437  PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 494
           68899************************.***********..79999**********997 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MAAEMRLPTI QKQGSMSIYG KGRKDLVVPG DIITSDTGFM RGHGTYVDED KLTASVAGEV 60
ERVDKLICVK PLKTRFNGEV GDVVVGRITE VQQKRWKVET NSRLDSVLLL SAVNLPGGEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGCTG AAATGAGATT ACCAACTATT CAAAAACAAG GATCTATGTC TATTTATGGA 60
AAGGGCAGAA AGGATTTGGT GGTGCCCGGC GACATTATCA CATCAGACAC AGGATTCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR025721--Exosome_cplx_N_dom
IPR015015--F-actin_binding
IPR004088--KH_dom_type_1
IPR011009--Kinase-like_dom
IPR012340--NA-bd_OB-fold
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF14382--ECR1_N
PF15985--KH_6
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0003723--F:RNA binding
GO:0030154--P:cell differentiation
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001550	Ailuropoda melanoleuca	66.42	0.00e+00	1055.00
IUUC-Apl-003452	Anas platyrhynchos	61.36	0.00e+00	1068.00
IUUC-Aca-005312	Anolis carolinensis	69.25	0.00e+00	1047.00
IUUC-Ame-011903	Astyanax mexicanus	74.50	0.00e+00	1189.00
IUUC-Bta-012351	Bos taurus	68.81	0.00e+00	1030.00
IUUC-Cja-019491	Callithrix jacchus	59.35	0.00e+00	1112.00
IUUC-Cfa-021256	Canis familiaris	66.43	0.00e+00	1077.00
IUUC-Cpo-022046	Cavia porcellus	70.15	0.00e+00	1081.00
IUUC-Csa-023046	Chlorocebus sabaeus	61.59	0.00e+00	1102.00
IUUC-Dre-028190	Danio rerio	64.46	0.00e+00	1163.00
IUUC-Dno-029853	Dasypus novemcinctus	59.67	0.00e+00	1103.00
IUUC-Dor-030635	Dipodomys ordii	62.97	0.00e+00	932.00
IUUC-Eca-033720	Equus caballus	69.07	0.00e+00	1023.00
IUUC-Eeu-035173	Erinaceus europaeus	62.67	0.00e+00	999.00
IUUC-Fca-035967	Felis catus	58.60	0.00e+00	1087.00
IUUC-Fal-036723	Ficedula albicollis	61.95	0.00e+00	1073.00
IUUC-Gmo-039550	Gadus morhua	77.87	0.00e+00	1222.00
IUUC-Gga-040481	Gallus gallus	83.71	0.00e+00	971.00
IUUC-Gac-041643	Gasterosteus aculeatus	74.75	0.00e+00	1525.00
IUUC-Ggo-045299	Gorilla gorilla	59.38	0.00e+00	1124.00
IUUC-Hsa-047033	Homo sapiens	69.70	1.00e-32	130.00
IUUC-Itr-047935	Ictidomys tridecemlineatus	60.88	0.00e+00	1069.00
IUUC-Lch-050530	Latimeria chalumnae	61.09	0.00e+00	1145.00
IUUC-Loc-052430	Lepisosteus oculatus	82.60	0.00e+00	1492.00
IUUC-Laf-053609	Loxodonta africana	65.36	0.00e+00	1059.00
IUUC-Mcc-055654	Macaca mulatta	60.08	0.00e+00	1140.00
IUUC-Meu-056488	Macropus eugenii	53.86	0.00e+00	938.00
IUUC-Mga-059270	Meleagris gallopavo	60.83	0.00e+00	1064.00
IUUC-Mmr-060593	Microcebus murinus	72.42	0.00e+00	1028.00
IUUC-Mdo-062227	Monodelphis domestica	72.44	0.00e+00	1025.00
IUUC-Mmu-064002	Mus musculus	67.68	0.00e+00	1105.00
IUUC-Mpu-066197	Mustela putorius furo	68.24	0.00e+00	1053.00
IUUC-Mlu-067255	Myotis lucifugus	60.65	0.00e+00	1049.00
IUUC-Nle-069977	Nomascus leucogenys	66.02	0.00e+00	972.00
IUUC-Opr-070327	Ochotona princeps	55.89	0.00e+00	926.00
IUUC-Ont-072307	Oreochromis niloticus	73.88	0.00e+00	1477.00
IUUC-Oan-073100	Ornithorhynchus anatinus	69.79	0.00e+00	1062.00
IUUC-Ocu-074892	Oryctolagus cuniculus	70.19	0.00e+00	936.00
IUUC-Ola-087389	Oryzias latipes	68.14	0.00e+00	1383.00
IUUC-Oga-088145	Otolemur garnettii	61.26	0.00e+00	1081.00
IUUC-Oar-090432	Ovis aries	71.64	0.00e+00	1016.00
IUUC-Ptr-090800	Pan troglodytes	59.89	0.00e+00	1134.00
IUUC-Psi-093078	Pelodiscus sinensis	62.15	0.00e+00	1115.00
IUUC-Pfo-096979	Poecilia formosa	70.59	0.00e+00	1340.00
IUUC-Pca-100874	Procavia capensis	83.93	0.00e+00	674.00
IUUC-Pva-102415	Pteropus vampyrus	69.56	0.00e+00	1061.00
IUUC-Rno-105682	Rattus norvegicus	67.56	0.00e+00	1108.00
IUUC-Sha-106711	Sarcophilus harrisii	70.25	0.00e+00	1056.00
IUUC-Ssc-115472	Sus scrofa	65.67	0.00e+00	1065.00
IUUC-Tgu-117037	Taeniopygia guttata	60.52	0.00e+00	1118.00
IUUC-Tsy-119216	Tarsius syrichta	82.64	0.00e+00	952.00
IUUC-Tni-119950	Tetraodon nigroviridis	91.72	0.00e+00	2484.00
IUUC-Ttr-128209	Tursiops truncatus	59.82	0.00e+00	1118.00
IUUC-Xtr-132477	Xenopus tropicalis	66.58	0.00e+00	922.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence