• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064083
UUCD1 version UUC-MuM-01037
Ensembl Protein ID ENSMUSP00000074387.5
UniProt Accession Q9WUQ2; Q9QZ99; PREB_MOUSE
Genbank Protein ID AAD31722.1; AAF07954.1; AAH17527.1
Protein Name Prolactin regulatory element-binding protein; Mammalian guanine nucleotide exchange factor mSec12
Genbank Nucleotide ID AF150808; AF193017; BC017527
Gene Name Preb; Sec12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000045302.13 ENSMUST00000201821.3 ENSMUSP00000144321.1
ENSMUSG00000045302.13 ENSMUST00000074840.11 ENSMUSP00000074387.5
ENSMUSG00000045302.13 ENSMUST00000201002.3 ENSMUSP00000143990.1
ENSMUSG00000045302.13 ENSMUST00000202567.1 ENSMUSP00000144263.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
iRefIndexMentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusdbPTMUniProt
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.30e-07 30.3 160 185
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 9    laf.sd.tllvsGsdDgtikvWDlrt 32
           ++f +d tll++G+ Dg ++vW + +
   Q: 160  VCFnHDnTLLATGGTDGHVRVWKVPS 185
           5688566***************9865 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.
 Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.
Protein Sequence
(Fasta)
MGRRRGVELY RAPFPLYALR IDPKTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGCLSAS 60
LLHSHDTETR ATMNLALAGD ILAAGQDAQC QLLRFQVHQQ KGSKAEKSGS KEQGPRQRKG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064083|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGACGCGG ATTGGCGTCT TGCGCTTGCG CAGAGAGAGC CCAGGAGCTC GGCGCGTGCG 60
CACTGAACGC CTGCAAGACC CAGTCGGCCG CGCGGGCGCA GATCGGCTGC TTGCGGTGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064083|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0256--Endoplasmic reticulum
KW-0931--ER-Golgi transport
KW-0472--Membrane
KW-0944--Nitration
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0070971--C:endoplasmic reticulum exit site
GO:0000139--C:Golgi membrane
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0005096--F:GTPase activator activity
GO:0051020--F:GTPase binding
GO:0005090--F:Sar guanyl-nucleotide exchange factor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0048208--P:COPII vesicle coating
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0032527--P:protein exit from endoplasmic reticulum
GO:0009306--P:protein secretion
GO:0003400--P:regulation of COPII vesicle coating
GO:0006351--P:transcription, DNA-templated
KEGG mmu:50907
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000155 Aegilops tauschii 23.11 1.00e-09 57.40
IUUC-Aml-001671 Ailuropoda melanoleuca 87.14 0.00e+00 642.00
IUUC-Atr-002477 Amborella trichopoda 25.00 2.00e-11 63.20
IUUC-Aly-005479 Arabidopsis lyrata 26.98 5.00e-14 72.40
IUUC-Ath-006922 Arabidopsis thaliana 28.22 2.00e-15 77.00
IUUC-Ame-010812 Astyanax mexicanus 46.86 7.00e-62 230.00
IUUC-Bta-012386 Bos taurus 89.23 0.00e+00 697.00
IUUC-Bdi-014110 Brachypodium distachyon 25.53 3.00e-19 89.40
IUUC-Bra-017708 Brassica rapa 30.04 3.00e-18 85.90
IUUC-Cel-018480 Caenorhabditis elegans 23.18 6.00e-19 88.60
IUUC-Cja-018998 Callithrix jacchus 86.92 0.00e+00 705.00
IUUC-Cfa-020666 Canis familiaris 87.32 0.00e+00 670.00
IUUC-Cpo-022030 Cavia porcellus 78.33 2.00e-176 611.00
IUUC-Csa-023521 Chlorocebus sabaeus 88.28 0.00e+00 665.00
IUUC-Cin-025431 Ciona intestinalis 32.13 1.00e-44 174.00
IUUC-Dre-027832 Danio rerio 54.59 7.00e-128 450.00
IUUC-Dno-028989 Dasypus novemcinctus 86.60 0.00e+00 711.00
IUUC-Dme-031901 Drosophila melanogaster 31.72 5.00e-49 188.00
IUUC-Ete-032290 Echinops telfairi 85.65 0.00e+00 649.00
IUUC-Eca-033917 Equus caballus 88.76 0.00e+00 694.00
IUUC-Fca-036323 Felis catus 88.04 0.00e+00 691.00
IUUC-Gmo-038693 Gadus morhua 55.35 5.00e-125 441.00
IUUC-Gga-040702 Gallus gallus 66.59 6.00e-142 497.00
IUUC-Gac-042635 Gasterosteus aculeatus 54.94 3.00e-115 408.00
IUUC-Gma-043946 Glycine max 26.18 2.00e-17 83.60
IUUC-Ggo-044648 Gorilla gorilla 88.22 0.00e+00 643.00
IUUC-Hsa-046003 Homo sapiens 88.73 0.00e+00 674.00
IUUC-Itr-048613 Ictidomys tridecemlineatus 87.77 0.00e+00 678.00
IUUC-Lch-049473 Latimeria chalumnae 59.67 8.00e-138 483.00
IUUC-Lpe-051586 Leersia perrieri 25.20 2.00e-19 89.70
IUUC-Loc-052177 Lepisosteus oculatus 60.19 4.00e-137 481.00
IUUC-Laf-054366 Loxodonta africana 87.08 0.00e+00 676.00
IUUC-Mcc-055775 Macaca mulatta 88.07 0.00e+00 663.00
IUUC-Meu-056562 Macropus eugenii 76.32 1.00e-155 542.00
IUUC-Mtr-058661 Medicago truncatula 27.07 1.00e-19 90.90
IUUC-Mvi-060443 Microbotryum violaceum 25.35 6.00e-12 65.90
IUUC-Mmr-061126 Microcebus murinus 88.04 0.00e+00 647.00
IUUC-Mdo-062928 Monodelphis domestica 76.19 1.00e-157 549.00
IUUC-Mac-064955 Musa acuminata 26.56 1.00e-16 80.50
IUUC-Mpu-066857 Mustela putorius furo 86.60 0.00e+00 707.00
IUUC-Mlu-067891 Myotis lucifugus 87.80 0.00e+00 668.00
IUUC-Nle-070030 Nomascus leucogenys 86.33 0.00e+00 645.00
IUUC-Opr-070864 Ochotona princeps 89.18 1.00e-128 453.00
IUUC-Ont-072204 Oreochromis niloticus 57.21 3.00e-125 441.00
IUUC-Oan-073643 Ornithorhynchus anatinus 68.01 6.00e-112 397.00
IUUC-Ocu-074217 Oryctolagus cuniculus 85.89 0.00e+00 630.00
IUUC-Oba-075587 Oryza barthii 26.99 9.00e-19 87.40
IUUC-Obr-076826 Oryza brachyantha 24.75 1.00e-19 90.50
IUUC-Ogl-077927 Oryza glaberrima 25.28 3.00e-19 89.70
IUUC-Ogu-078241 Oryza glumaepatula 25.28 4.00e-19 89.00
IUUC-Oin-080217 Oryza indica 25.28 5.00e-19 89.00
IUUC-Olo-081060 Oryza longistaminata 25.28 3.00e-19 89.40
IUUC-Ome-082007 Oryza meridionalis 25.28 2.00e-19 89.70
IUUC-Oni-082827 Oryza nivara 25.28 5.00e-19 89.00
IUUC-Opu-083159 Oryza punctata 25.28 2.00e-18 87.00
IUUC-Oru-085039 Oryza rufipogon 25.28 5.00e-19 89.00
IUUC-Osa-086258 Oryza sativa 25.28 5.00e-19 89.00
IUUC-Ola-087223 Oryzias latipes 58.18 5.00e-119 421.00
IUUC-Oga-088417 Otolemur garnettii 84.93 0.00e+00 626.00
IUUC-Oar-090435 Ovis aries 89.23 0.00e+00 699.00
IUUC-Ptr-090869 Pan troglodytes 88.25 0.00e+00 644.00
IUUC-Pan-092527 Papio anubis 88.28 0.00e+00 665.00
IUUC-Pma-094156 Petromyzon marinus 51.69 3.00e-108 385.00
IUUC-Ppa-095904 Physcomitrella patens 26.77 3.00e-12 66.20
IUUC-Pfo-097488 Poecilia formosa 52.57 4.00e-119 421.00
IUUC-Pab-097720 Pongo abelii 88.49 0.00e+00 669.00
IUUC-Pop-099618 Populus trichocarpa 27.63 1.00e-19 90.90
IUUC-Pca-100288 Procavia capensis 76.13 2.00e-163 568.00
IUUC-Ppe-101864 Prunus persica 26.64 6.00e-13 68.60
IUUC-Pva-103192 Pteropus vampyrus 88.04 0.00e+00 679.00
IUUC-Rno-106123 Rattus norvegicus 96.88 0.00e+00 709.00
IUUC-Sha-107169 Sarcophilus harrisii 78.10 2.00e-161 561.00
IUUC-Smo-109265 Selaginella moellendorffii 28.34 2.00e-14 73.60
IUUC-Sly-111551 Solanum lycopersicum 28.57 3.00e-14 73.20
IUUC-Stu-112264 Solanum tuberosum 28.57 3.00e-13 69.30
IUUC-Sar-113218 Sorex araneus 83.26 7.00e-107 379.00
IUUC-Ssc-115282 Sus scrofa 86.99 0.00e+00 653.00
IUUC-Tru-117866 Takifugu rubripes 55.35 5.00e-120 424.00
IUUC-Tca-121083 Theobroma cacao 28.91 4.00e-18 85.90
IUUC-Tae-124218 Triticum aestivum 25.70 1.00e-17 83.60
IUUC-Tur-126597 Triticum urartu 22.48 4.00e-08 52.00
IUUC-Ttr-128585 Tursiops truncatus 85.65 0.00e+00 628.00
IUUC-Vvi-131024 Vitis vinifera 28.52 8.00e-20 91.30
IUUC-Xma-134081 Xiphophorus maculatus 52.59 5.00e-117 414.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved