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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047005
Ensembl Protein ID ENSP00000312778.7
UniProt Accession Q9P2H3; B4E0K1; C9J8I0; Q3MJC4; Q86YF4; Q9UIX1; IFT80_HUMAN
Genbank Protein ID BAG64463.1; EAW78643.1; EAW78644.1; EAW78645.1; EAW78646.1; EAW78648.1; AAH42027.1; AAI01495.1; AAI13670.1; BAA92612.1; CAB61372.1
Protein Name Intraflagellar transport protein 80 homolog; WD repeat-containing protein 56
Genbank Nucleotide ID AK303410; AC024221; CH471052; CH471052; CH471052; CH471052; BC030774; BC101494; BC113669; AB037795; AL133045
Gene Name IFT80; KIAA1374; WDR56
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000068885.14 ENST00000326448.11 ENSP00000312778.7
ENSG00000068885.14 ENST00000483325.1 ENSP00000417552.1
ENSG00000068885.14 ENST00000472555.5 ENSP00000420401.1
ENSG00000068885.14 ENST00000484963.5 ENSP00000420260.1
ENSG00000068885.14 ENST00000482317.5 ENSP00000418497.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.50e-13 52.0 228 256
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H+ ++t++a+ +d  l+++Gs  +t++++D
   Q: 228  HEHPITSVAWaPDgELFAVGS-FHTLRLCD 256
           99*********9978888887.689*9999 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.
 Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.
Protein Sequence
(Fasta)
MRLKISLLKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETTQI VKLPDDIYPI 60
DFHWFPKSLG VKKQTQAESF VLTSSDGKFH LISKLGRVEK SVEAHCGAVL AGRWNYEGTA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047005|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGAAATCTC CCAGCGGCAG CTTCAAGCCC GGACTTCGCC GCTCGGGCTC AAGGCCTCTA 60
TTTTCCAGGC GCTCGCGGAC AAGGCAGGAA GTAAGAGCGT GACAACCTGA CCAGGAAGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047005|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-1186--Ciliopathy
KW-0969--Cilium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
SMART

SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0097542--C:ciliary tip
GO:0005929--C:cilium
GO:0005737--C:cytoplasm
GO:0030992--C:intraciliary transport particle B
GO:0060349--P:bone morphogenesis
GO:0002062--P:chondrocyte differentiation
GO:0060271--P:cilium assembly
GO:0035735--P:intraciliary transport involved in cilium assembly
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:1905515--P:non-motile cilium assembly
GO:0001649--P:osteoblast differentiation
GO:0045880--P:positive regulation of smoothened signaling pathway
GO:0007224--P:smoothened signaling pathway
KEGG hsa:57560
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001564 Ailuropoda melanoleuca 97.29 0.00e+00 902.00
IUUC-Apl-003721 Anas platyrhynchos 85.31 0.00e+00 1373.00
IUUC-Aca-004488 Anolis carolinensis 85.94 0.00e+00 1388.00
IUUC-Ame-011402 Astyanax mexicanus 80.60 0.00e+00 815.00
IUUC-Bta-013037 Bos taurus 86.39 0.00e+00 1318.00
IUUC-Cel-018360 Caenorhabditis elegans 41.05 0.00e+00 670.00
IUUC-Cfa-020999 Canis familiaris 95.79 0.00e+00 1513.00
IUUC-Cpo-021333 Cavia porcellus 85.88 0.00e+00 1301.00
IUUC-Cre-022899 Chlamydomonas reinhardtii 46.60 0.00e+00 679.00
IUUC-Csa-023699 Chlorocebus sabaeus 99.48 0.00e+00 1565.00
IUUC-Cho-024904 Choloepus hoffmanni 86.96 0.00e+00 828.00
IUUC-Cin-025399 Ciona intestinalis 57.56 0.00e+00 961.00
IUUC-Csv-026186 Ciona savignyi 55.72 0.00e+00 930.00
IUUC-Dre-028276 Danio rerio 74.80 0.00e+00 1267.00
IUUC-Dno-029824 Dasypus novemcinctus 96.33 0.00e+00 1519.00
IUUC-Dor-031141 Dipodomys ordii 91.37 0.00e+00 1419.00
IUUC-Dme-031620 Drosophila melanogaster 36.24 1.00e-144 507.00
IUUC-Eca-033339 Equus caballus 94.85 0.00e+00 1491.00
IUUC-Eeu-034909 Erinaceus europaeus 93.42 0.00e+00 983.00
IUUC-Fca-035780 Felis catus 96.73 0.00e+00 1490.00
IUUC-Fal-037447 Ficedula albicollis 79.39 0.00e+00 1268.00
IUUC-Gga-040689 Gallus gallus 85.52 0.00e+00 1373.00
IUUC-Itr-048757 Ictidomys tridecemlineatus 96.26 0.00e+00 1108.00
IUUC-Lch-050459 Latimeria chalumnae 81.67 0.00e+00 1318.00
IUUC-Laf-053765 Loxodonta africana 94.18 0.00e+00 1461.00
IUUC-Mcc-055052 Macaca mulatta 99.48 0.00e+00 1565.00
IUUC-Meu-056368 Macropus eugenii 81.50 0.00e+00 1261.00
IUUC-Mga-059488 Meleagris gallopavo 85.81 0.00e+00 1379.00
IUUC-Mmr-061527 Microcebus murinus 96.51 0.00e+00 1498.00
IUUC-Mmu-063117 Mus musculus 94.72 0.00e+00 1492.00
IUUC-Mpu-066550 Mustela putorius furo 96.38 0.00e+00 1372.00
IUUC-Mlu-067772 Myotis lucifugus 91.60 0.00e+00 1400.00
IUUC-Nle-069215 Nomascus leucogenys 98.71 0.00e+00 1572.00
IUUC-Opr-070725 Ochotona princeps 73.83 0.00e+00 1102.00
IUUC-Ont-072147 Oreochromis niloticus 74.15 0.00e+00 1255.00
IUUC-Oga-088113 Otolemur garnettii 94.82 0.00e+00 1521.00
IUUC-Oar-089683 Ovis aries 92.30 0.00e+00 1448.00
IUUC-Ptr-091563 Pan troglodytes 99.61 0.00e+00 1583.00
IUUC-Pan-092042 Papio anubis 99.22 0.00e+00 1559.00
IUUC-Psi-093306 Pelodiscus sinensis 87.53 0.00e+00 1438.00
IUUC-Ppa-095694 Physcomitrella patens 44.53 0.00e+00 715.00
IUUC-Pfo-096800 Poecilia formosa 73.69 0.00e+00 1238.00
IUUC-Pab-098356 Pongo abelii 99.49 0.00e+00 1587.00
IUUC-Pva-102246 Pteropus vampyrus 91.03 0.00e+00 1405.00
IUUC-Rno-105195 Rattus norvegicus 94.34 0.00e+00 1494.00
IUUC-Sha-107056 Sarcophilus harrisii 94.23 0.00e+00 1481.00
IUUC-Smo-109240 Selaginella moellendorffii 44.16 3.00e-175 608.00
IUUC-Sar-113301 Sorex araneus 85.71 2.00e-147 516.00
IUUC-Ssc-116040 Sus scrofa 96.85 4.00e-148 517.00
IUUC-Tgu-117127 Taeniopygia guttata 81.68 0.00e+00 1322.00
IUUC-Tru-118663 Takifugu rubripes 71.43 0.00e+00 1203.00
IUUC-Tsy-119207 Tarsius syrichta 84.92 0.00e+00 1312.00
IUUC-Tni-120705 Tetraodon nigroviridis 70.03 0.00e+00 1191.00
IUUC-Ttr-128937 Tursiops truncatus 96.52 0.00e+00 1524.00
IUUC-Vpa-130518 Vicugna pacos 91.11 0.00e+00 1396.00
IUUC-Xtr-131879 Xenopus tropicalis 77.95 0.00e+00 1281.00
Created Date 25-Jun-2017

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