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Tag Content
iUUCD ID IUUC-Mla-058847
Ensembl Protein ID EGG09345
UniProt Accession F4RE34; F4RE34_MELLP
Genbank Protein ID EGG09345.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID GL883098
Gene Name URM1; MELLADRAFT_71254
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
MELLADRAFT_71254 EGG09345 EGG09345
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 37.86 2.00e-13 68.90 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Melampsora laricipopulina
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MDSATPSTQS ADPGGTGLRQ IKLKVELGGG LETLFGNSTT MMMELSEPFD IRHLISVLAT 60
RVNPPTSLSL FCSPGPEWDI KPGILPLVND EDWELLEPSG MEAVLKDGDN VLFISTLHGG 120
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Protein Fasta Sequence


>IUUC-Mla-058847|ULD,UBQ_Other|Melampsora laricipopulina
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Nucleotide Sequence
(Fasta)
TGACGGCAAG ACGAGATTGC ATTGCCCGGC ACAGATCTGG TACGGCTGCT CACCGTTCTC 60
GACATGGACT CCGCGACACC ATCAACACAA TCTGCTGATC CAGGGGGGAC TGGCCTTCGT 120
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Nucleotide Fasta Sequence


>IUUC-Mla-058847|ULD,UBQ_Other|Melampsora laricipopulina
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
KEGG mlr:MELLADRAFT_71254
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 41.75 4.00e-13 64.30
IUUC-Atr-003089 Amborella trichopoda 36.79 6.00e-09 50.10
IUUC-Apl-003382 Anas platyrhynchos 42.11 6.00e-12 60.10
IUUC-Aca-004981 Anolis carolinensis 37.86 2.00e-12 62.00
IUUC-Aly-005517 Arabidopsis lyrata 53.66 4.00e-08 47.40
IUUC-Ath-006718 Arabidopsis thaliana 53.66 3.00e-08 47.80
IUUC-Ago-007917 Ashbya gossypii 34.62 6.00e-11 57.00
IUUC-Acl-008054 Aspergillus clavatus 54.55 6.00e-09 49.70
IUUC-Afl-008704 Aspergillus flavus 41.43 2.00e-08 48.50
IUUC-Aor-009890 Aspergillus oryzae 39.50 9.00e-12 60.10
IUUC-Bta-012448 Bos taurus 41.75 5.00e-13 63.90
IUUC-Bci-013865 Botrytis cinerea 33.02 2.00e-11 58.20
IUUC-Bdi-014980 Brachypodium distachyon 58.54 4.00e-09 50.80
IUUC-Bol-016055 Brassica oleracea 53.66 3.00e-08 47.80
IUUC-Bra-016845 Brassica rapa 53.66 3.00e-08 47.80
IUUC-Cel-018485 Caenorhabditis elegans 40.48 1.00e-04 36.20
IUUC-Cja-019587 Callithrix jacchus 40.78 4.00e-13 63.90
IUUC-Cfa-020653 Canis familiaris 40.78 7.00e-13 63.50
IUUC-Cpo-021622 Cavia porcellus 40.78 4.00e-13 63.90
IUUC-Cre-023015 Chlamydomonas reinhardtii 39.42 3.00e-12 61.20
IUUC-Csa-023756 Chlorocebus sabaeus 36.71 2.00e-06 42.40
IUUC-Cgl-026518 Colletotrichum gloeosporioides 39.67 8.00e-16 73.20
IUUC-Cne-026953 Cryptococcus neoformans 31.67 4.00e-11 58.20
IUUC-Cme-027314 Cyanidioschyzon merolae 58.54 1.00e-09 52.40
IUUC-Dre-027884 Danio rerio 38.61 4.00e-12 60.80
IUUC-Dno-029262 Dasypus novemcinctus 36.71 1.00e-06 43.90
IUUC-Dor-030601 Dipodomys ordii 61.11 2.00e-05 38.50
IUUC-Dme-031893 Drosophila melanogaster 36.89 1.00e-10 55.80
IUUC-Ete-032773 Echinops telfairi 41.35 2.00e-11 58.90
IUUC-Eca-034187 Equus caballus 39.81 7.00e-13 63.50
IUUC-Eeu-034808 Erinaceus europaeus 40.78 5.00e-13 63.90
IUUC-Fca-036107 Felis catus 41.75 1.00e-13 65.90
IUUC-Fal-036607 Ficedula albicollis 40.00 6.00e-11 56.60
IUUC-Fox-037698 Fusarium oxysporum 39.81 6.00e-15 70.10
IUUC-Gmo-039492 Gadus morhua 38.83 2.00e-12 61.60
IUUC-Ggr-039965 Gaeumannomyces graminis 40.20 7.00e-13 64.30
IUUC-Gga-041268 Gallus gallus 41.75 5.00e-14 67.00
IUUC-Gac-042111 Gasterosteus aculeatus 40.78 1.00e-13 65.50
IUUC-Gma-043240 Glycine max 56.10 7.00e-08 46.60
IUUC-Ggo-045176 Gorilla gorilla 36.71 5.00e-05 38.10
IUUC-Hsa-046077 Homo sapiens 40.78 2.00e-11 58.50
IUUC-Itr-048111 Ictidomys tridecemlineatus 41.05 9.00e-10 52.80
IUUC-Kpa-049157 Komagataella pastoris 34.65 2.00e-10 55.50
IUUC-Lch-049889 Latimeria chalumnae 42.72 2.00e-14 68.60
IUUC-Lpe-050783 Leersia perrieri 55.00 7.00e-08 46.60
IUUC-Loc-052400 Lepisosteus oculatus 38.83 1.00e-11 59.30
IUUC-Lma-053259 Leptosphaeria maculans 37.74 1.00e-11 59.70
IUUC-Laf-053596 Loxodonta africana 40.78 8.00e-15 69.70
IUUC-Mcc-054845 Macaca mulatta 40.43 2.00e-10 55.10
IUUC-Meu-055968 Macropus eugenii 40.78 2.00e-13 65.10
IUUC-Mor-057126 Magnaporthe oryzae 35.94 7.00e-13 63.90
IUUC-Mpo-057311 Magnaporthe poae 39.62 6.00e-14 67.80
IUUC-Mtr-058266 Medicago truncatula 53.66 1.00e-07 46.20
IUUC-Mga-059468 Meleagris gallopavo 41.05 2.00e-11 58.20
IUUC-Mvi-060235 Microbotryum violaceum 47.22 2.00e-10 56.60
IUUC-Mdo-061948 Monodelphis domestica 38.83 1.00e-12 62.80
IUUC-Mmu-063946 Mus musculus 41.58 2.00e-13 65.10
IUUC-Mac-064812 Musa acuminata 53.66 2.00e-08 48.50
IUUC-Mpu-066763 Mustela putorius furo 38.83 1.00e-11 59.30
IUUC-Mlu-066970 Myotis lucifugus 36.71 3.00e-07 43.90
IUUC-Ncr-068824 Neurospora crassa 38.89 7.00e-14 66.60
IUUC-Nle-069849 Nomascus leucogenys 36.71 4.00e-06 42.00
IUUC-Opr-070227 Ochotona princeps 40.78 4.00e-13 63.90
IUUC-Ont-072530 Oreochromis niloticus 40.78 8.00e-13 63.20
IUUC-Oan-073191 Ornithorhynchus anatinus 42.11 2.00e-13 64.70
IUUC-Ocu-074460 Oryctolagus cuniculus 41.75 9.00e-14 66.20
IUUC-Oba-075499 Oryza barthii 56.10 4.00e-08 48.50
IUUC-Obr-076896 Oryza brachyantha 56.10 4.00e-08 49.30
IUUC-Ogl-077834 Oryza glaberrima 56.10 2.00e-08 48.50
IUUC-Ogu-078622 Oryza glumaepatula 56.10 2.00e-08 48.50
IUUC-Oin-079358 Oryza indica 56.10 6.00e-08 48.50
IUUC-Olo-081035 Oryza longistaminata 56.10 2.00e-08 49.70
IUUC-Oni-082425 Oryza nivara 56.10 2.00e-08 48.50
IUUC-Opu-083461 Oryza punctata 55.00 2.00e-07 46.60
IUUC-Oru-084875 Oryza rufipogon 57.50 2.00e-08 47.80
IUUC-Oga-089128 Otolemur garnettii 39.81 8.00e-13 63.20
IUUC-Oar-089896 Ovis aries 41.75 5.00e-13 63.90
IUUC-Ptr-091618 Pan troglodytes 36.71 5.00e-05 38.10
IUUC-Pan-092238 Papio anubis 36.71 2.00e-06 42.70
IUUC-Psi-093879 Pelodiscus sinensis 39.81 3.00e-12 61.20
IUUC-Pma-094484 Petromyzon marinus 40.74 5.00e-09 50.40
IUUC-Ppa-095801 Physcomitrella patens 56.10 2.00e-09 51.60
IUUC-Pfo-097192 Poecilia formosa 38.83 6.00e-12 60.10
IUUC-Pab-098203 Pongo abelii 40.78 3.00e-11 58.20
IUUC-Pop-099614 Populus trichocarpa 53.66 3.00e-07 44.30
IUUC-Pca-100507 Procavia capensis 37.97 2.00e-07 44.30
IUUC-Ppe-101174 Prunus persica 36.19 4.00e-10 53.90
IUUC-Pva-102735 Pteropus vampyrus 41.18 2.00e-12 62.00
IUUC-Pgr-103510 Puccinia graminis 62.18 6.00e-41 157.00
IUUC-Ptt-103918 Puccinia triticina 71.00 3.00e-39 151.00
IUUC-Pte-104173 Pyrenophora teres 32.08 1.00e-10 55.80
IUUC-Pyt-104806 Pyrenophora triticirepentis 35.85 3.00e-11 58.20
IUUC-Rno-105820 Rattus norvegicus 41.58 3.00e-13 64.70
IUUC-Sce-106366 Saccharomyces cerevisiae 37.86 1.00e-14 68.90
IUUC-Sja-107727 Schizosaccharomyces japonicus 36.36 4.00e-14 67.40
IUUC-Spo-108074 Schizosaccharomyces pombe 40.00 7.00e-10 53.10
IUUC-Smo-108944 Selaginella moellendorffii 40.86 5.00e-11 56.60
IUUC-Sit-110277 Setaria italica 56.10 2.00e-08 48.50
IUUC-Sly-111505 Solanum lycopersicum 60.98 6.00e-10 53.50
IUUC-Stu-112076 Solanum tuberosum 60.98 6.00e-10 53.50
IUUC-Sbi-114274 Sorghum bicolor 58.54 1.00e-08 49.70
IUUC-Sre-114953 Sporisorium reilianum 38.89 3.00e-10 55.10
IUUC-Ssc-115418 Sus scrofa 38.83 9.00e-13 62.80
IUUC-Tgu-117311 Taeniopygia guttata 40.00 5.00e-11 56.60
IUUC-Tru-118598 Takifugu rubripes 40.00 1.00e-11 58.50
IUUC-Tni-120109 Tetraodon nigroviridis 37.86 1.00e-10 55.80
IUUC-Tca-120942 Theobroma cacao 53.66 9.00e-08 46.20
IUUC-Tre-122099 Trichoderma reesei 39.80 6.00e-10 53.10
IUUC-Tvi-122285 Trichoderma virens 40.19 1.00e-11 59.30
IUUC-Tae-125193 Triticum aestivum 58.54 5.00e-09 50.40
IUUC-Tur-126677 Triticum urartu 60.00 9.00e-09 49.70
IUUC-Tme-127120 Tuber melanosporum 36.13 4.00e-15 71.20
IUUC-Tbe-128050 Tupaia belangeri 62.50 7.00e-09 50.10
IUUC-Ttr-129019 Tursiops truncatus 38.24 7.00e-11 56.60
IUUC-Uma-129483 Ustilago maydis 37.50 6.00e-10 53.90
IUUC-Vda-129690 Verticillium dahliae 65.85 2.00e-09 52.00
IUUC-Vvi-131174 Vitis vinifera 51.22 1.00e-07 45.40
IUUC-Xma-133862 Xiphophorus maculatus 38.83 6.00e-12 60.10
IUUC-Yli-134398 Yarrowia lipolytica 29.81 3.00e-09 50.80
IUUC-Zma-134964 Zea mays 56.10 1.00e-08 48.90
Created Date 25-Jun-2017

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