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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106157
Ensembl Protein ID YHR165C
UniProt Accession P33334; D3DLB4; PRP8_YEAST
Genbank Protein ID CAA80854.1; AAA67044.1; AAB68011.1; DAA06858.1
Protein Name Pre-mRNA-splicing factor 8
Genbank Nucleotide ID Z24732; L29421; U00027; BK006934
Gene Name PRP8; DBF3; DNA39; RNA8; SLT21; USA2; YHR165C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YHR165C YHR165C YHR165C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Jab_MPN Jab_MPN 16428608; 17317632
Classification
Family E-value Score Start End
UBD/Jab_MPN 1.90e-60 201.1 2178 2310
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Jab_MPN
   S: 1    eekevvvlpkrllkkflelsdvkiavavevyGlllgelvkdkevktvvlvpkqlagvgsvqvenvedvfdlldqeGlivlGWiHthpeelkflssvdvat 100
           ee++v+vlpk+llkkf+e+sdvki+va+++yG+++++++k+ke+ktvvlvp ql++vgsvq++n++d++dl+d+eGl++lGWiHt++eelkf+++++vat
   Q: 2178 EEQNVYVLPKNLLKKFIEISDVKIQVAAFIYGMSAKDHPKVKEIKTVVLVP-QLGHVGSVQISNIPDIGDLPDTEGLELLGWIHTQTEELKFMAASEVAT 2276
           79*************************************************.************************************************ PP
   S: 101  hsslealkkr...svaivsspkfqelsafkltde 131
           hs+l+a+kkr   +++i+s+p++++lsa++ltde
   Q: 2277 HSKLFADKKRdciDISIFSTPGSVSLSAYNLTDE 2310
           **********9999*******************7 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for association of BRR2 with the spliceosomal U5 snRNP, and the subsequent assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site, as well as the branch region. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.
 Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for association of BRR2 with the spliceosomal U5 snRNP, and the subsequent assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site, as well as the branch region. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.
Protein Sequence
(Fasta)
MSGLPPPPPG FEEDSDLALP PPPPPPPGYE IEELDNPMVP SSVNEDTFLP PPPPPPSNFE 60
INAEEIVDFT LPPPPPPPGL DELETKAEKK VELHGKRKLD IGKDTFVTRK SRKRAKKMTK 120
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Protein Fasta Sequence


>IUUC-Sce-106157|UBD,Jab_MPN|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGAGTGGAC TACCGCCCCC ACCTCCTGGT TTTGAAGAGG ACAGCGACTT AGCACTTCCA 60
CCACCACCAC CACCACCGCC TGGATACGAA ATCGAAGAAC TGGATAATCC GATGGTGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106157|UBD,Jab_MPN|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0747--Spliceosome
Interpro

IPR000555--JAMM/MPN+_dom
IPR012591--PRO8NT
IPR012592--PROCN
IPR012984--PROCT
IPR027652--PRP8
IPR021983--PRP8_domainIV
IPR019581--Prp8_U5-snRNA-bd
IPR019580--Prp8_U6-snRNA-bd
IPR012337--RNaseH-like_dom
IPR019582--RRM_spliceosomal_PrP8
Pfam

PF08082--PRO8NT
PF08083--PROCN
PF08084--PROCT
PF12134--PRP8_domainIV
PF10598--RRM_4
PF10597--U5_2-snRNA_bdg
PF10596--U6-snRNA_bdg
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0005682--C:U5 snRNP
GO:0097157--F:pre-mRNA intronic binding
GO:0030619--F:U1 snRNA binding
GO:0030620--F:U2 snRNA binding
GO:0030623--F:U5 snRNA binding
GO:0017070--F:U6 snRNA binding
GO:0000350--P:generation of catalytic spliceosome for second transesterification step
GO:0000389--P:mRNA 3'-splice site recognition
GO:0000244--P:spliceosomal tri-snRNP complex assembly
KEGG sce:YHR165C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001091 Aegilops tauschii 62.58 0.00e+00 2940.00
IUUC-Aml-002261 Ailuropoda melanoleuca 62.26 0.00e+00 2945.00
IUUC-Atr-002524 Amborella trichopoda 61.53 0.00e+00 2932.00
IUUC-Apl-004039 Anas platyrhynchos 62.80 0.00e+00 2902.00
IUUC-Aca-005394 Anolis carolinensis 64.60 0.00e+00 2492.00
IUUC-Aly-005909 Arabidopsis lyrata 61.42 0.00e+00 2928.00
IUUC-Ath-007237 Arabidopsis thaliana 61.99 0.00e+00 2941.00
IUUC-Ago-007815 Ashbya gossypii 75.90 0.00e+00 3678.00
IUUC-Acl-008111 Aspergillus clavatus 63.46 0.00e+00 3071.00
IUUC-Afl-008609 Aspergillus flavus 62.71 0.00e+00 1916.00
IUUC-Afu-009078 Aspergillus fumigatus 65.07 0.00e+00 2041.00
IUUC-Ani-009297 Aspergillus nidulans 64.39 0.00e+00 2016.00
IUUC-Ang-009749 Aspergillus niger 63.10 0.00e+00 3075.00
IUUC-Aor-010106 Aspergillus oryzae 62.98 0.00e+00 3060.00
IUUC-Ate-010566 Aspergillus terreus 63.25 0.00e+00 3070.00
IUUC-Ame-011416 Astyanax mexicanus 62.30 0.00e+00 2969.00
IUUC-Bgr-012078 Blumeria graminis 62.50 0.00e+00 1933.00
IUUC-Bta-013532 Bos taurus 62.26 0.00e+00 2945.00
IUUC-Bci-013914 Botrytis cinerea 64.65 0.00e+00 2023.00
IUUC-Bdi-014349 Brachypodium distachyon 61.88 0.00e+00 2929.00
IUUC-Bol-015707 Brassica oleracea 62.07 0.00e+00 2936.00
IUUC-Bra-017086 Brassica rapa 61.51 0.00e+00 2917.00
IUUC-Cel-018508 Caenorhabditis elegans 60.78 0.00e+00 2882.00
IUUC-Cja-019483 Callithrix jacchus 62.26 0.00e+00 2945.00
IUUC-Cfa-021018 Canis familiaris 62.26 0.00e+00 2945.00
IUUC-Cpo-022159 Cavia porcellus 62.26 0.00e+00 2945.00
IUUC-Cre-022998 Chlamydomonas reinhardtii 61.92 0.00e+00 2897.00
IUUC-Csa-023885 Chlorocebus sabaeus 62.26 0.00e+00 2945.00
IUUC-Cho-024639 Choloepus hoffmanni 65.86 0.00e+00 1866.00
IUUC-Cin-025356 Ciona intestinalis 50.63 2.00e-115 407.00
IUUC-Csv-025880 Ciona savignyi 60.92 0.00e+00 2900.00
IUUC-Cgl-026713 Colletotrichum gloeosporioides 61.53 0.00e+00 3003.00
IUUC-Cne-026874 Cryptococcus neoformans 63.39 0.00e+00 1804.00
IUUC-Cme-027252 Cyanidioschyzon merolae 35.79 0.00e+00 942.00
IUUC-Dre-027996 Danio rerio 62.39 0.00e+00 2971.00
IUUC-Dno-029708 Dasypus novemcinctus 63.90 0.00e+00 2819.00
IUUC-Dor-030119 Dipodomys ordii 59.58 0.00e+00 2660.00
IUUC-Dse-031333 Dothistroma septosporum 62.98 0.00e+00 3028.00
IUUC-Dme-031908 Drosophila melanogaster 62.40 0.00e+00 2909.00
IUUC-Ete-032766 Echinops telfairi 62.88 0.00e+00 2529.00
IUUC-Eca-034109 Equus caballus 62.26 0.00e+00 2945.00
IUUC-Eeu-035094 Erinaceus europaeus 65.96 0.00e+00 1634.00
IUUC-Fca-035567 Felis catus 65.83 0.00e+00 2578.00
IUUC-Fal-036613 Ficedula albicollis 62.34 0.00e+00 2949.00
IUUC-Fox-037855 Fusarium oxysporum 62.99 0.00e+00 3058.00
IUUC-Fso-038078 Fusarium solani 62.75 0.00e+00 3049.00
IUUC-Gmo-038986 Gadus morhua 61.25 0.00e+00 2917.00
IUUC-Ggr-039855 Gaeumannomyces graminis 62.45 0.00e+00 3024.00
IUUC-Gga-040719 Gallus gallus 62.34 0.00e+00 2950.00
IUUC-Gac-042502 Gasterosteus aculeatus 62.17 0.00e+00 2967.00
IUUC-Gma-043317 Glycine max 62.27 0.00e+00 2921.00
IUUC-Ggo-045622 Gorilla gorilla 59.17 0.00e+00 2722.00
IUUC-Hsa-046060 Homo sapiens 62.26 0.00e+00 2945.00
IUUC-Hvu-047251 Hordeum vulgare 64.32 0.00e+00 2824.00
IUUC-Itr-048517 Ictidomys tridecemlineatus 61.17 0.00e+00 1489.00
IUUC-Kpa-049289 Komagataella pastoris 66.19 0.00e+00 3229.00
IUUC-Lch-049690 Latimeria chalumnae 62.08 0.00e+00 2728.00
IUUC-Lpe-050868 Leersia perrieri 61.22 0.00e+00 2917.00
IUUC-Loc-052365 Lepisosteus oculatus 62.45 0.00e+00 2949.00
IUUC-Lma-053043 Leptosphaeria maculans 62.80 0.00e+00 3076.00
IUUC-Laf-053582 Loxodonta africana 62.26 0.00e+00 2945.00
IUUC-Mcc-055024 Macaca mulatta 62.26 0.00e+00 2945.00
IUUC-Meu-056637 Macropus eugenii 61.08 0.00e+00 2859.00
IUUC-Mor-057244 Magnaporthe oryzae 62.67 0.00e+00 3005.00
IUUC-Mpo-057580 Magnaporthe poae 62.41 0.00e+00 3024.00
IUUC-Mtr-058326 Medicago truncatula 62.22 0.00e+00 2944.00
IUUC-Mla-059121 Melampsora laricipopulina 60.02 0.00e+00 2793.00
IUUC-Mga-059789 Meleagris gallopavo 62.34 0.00e+00 2950.00
IUUC-Mvi-060563 Microbotryum violaceum 58.28 0.00e+00 2792.00
IUUC-Mmr-060880 Microcebus murinus 61.40 0.00e+00 2895.00
IUUC-Mdo-062237 Monodelphis domestica 62.26 0.00e+00 2945.00
IUUC-Mmu-064177 Mus musculus 62.21 0.00e+00 2943.00
IUUC-Mac-065558 Musa acuminata 60.98 0.00e+00 2828.00
IUUC-Mpu-066903 Mustela putorius furo 62.26 0.00e+00 2945.00
IUUC-Mlu-067424 Myotis lucifugus 62.18 0.00e+00 2935.00
IUUC-Nfi-068265 Neosartorya fischeri 65.23 0.00e+00 2042.00
IUUC-Ncr-068963 Neurospora crassa 62.81 0.00e+00 3037.00
IUUC-Nle-069111 Nomascus leucogenys 63.97 0.00e+00 2167.00
IUUC-Opr-070706 Ochotona princeps 61.65 0.00e+00 2905.00
IUUC-Ont-071405 Oreochromis niloticus 62.30 0.00e+00 2965.00
IUUC-Oan-073481 Ornithorhynchus anatinus 63.99 0.00e+00 1454.00
IUUC-Ocu-074231 Oryctolagus cuniculus 62.26 0.00e+00 2945.00
IUUC-Oba-075452 Oryza barthii 62.34 0.00e+00 2929.00
IUUC-Obr-076377 Oryza brachyantha 62.29 0.00e+00 2924.00
IUUC-Ogl-077666 Oryza glaberrima 61.85 0.00e+00 2934.00
IUUC-Ogu-078187 Oryza glumaepatula 62.38 0.00e+00 2931.00
IUUC-Oin-079234 Oryza indica 62.34 0.00e+00 2925.00
IUUC-Olo-080543 Oryza longistaminata 62.38 0.00e+00 2929.00
IUUC-Ome-081541 Oryza meridionalis 61.55 0.00e+00 2909.00
IUUC-Oni-082712 Oryza nivara 65.01 0.00e+00 2423.00
IUUC-Opu-083904 Oryza punctata 61.72 0.00e+00 2924.00
IUUC-Oru-084749 Oryza rufipogon 61.85 0.00e+00 2935.00
IUUC-Osa-085504 Oryza sativa 62.57 0.00e+00 1506.00
IUUC-Ola-087464 Oryzias latipes 62.38 0.00e+00 2834.00
IUUC-Olu-087705 Ostreococcus lucimarinus 61.88 0.00e+00 2969.00
IUUC-Oga-087910 Otolemur garnettii 79.07 6.00e-61 223.00
IUUC-Oar-089892 Ovis aries 62.18 0.00e+00 2942.00
IUUC-Ptr-090562 Pan troglodytes 73.50 0.00e+00 724.00
IUUC-Pan-092555 Papio anubis 62.67 0.00e+00 2942.00
IUUC-Psi-094049 Pelodiscus sinensis 62.21 0.00e+00 2946.00
IUUC-Pma-094240 Petromyzon marinus 61.24 0.00e+00 2807.00
IUUC-Pno-095146 Phaeosphaeria nodorum 61.72 0.00e+00 2967.00
IUUC-Ppa-095776 Physcomitrella patens 61.58 0.00e+00 2924.00
IUUC-Pfo-097177 Poecilia formosa 62.30 0.00e+00 2962.00
IUUC-Pab-097961 Pongo abelii 62.26 0.00e+00 2945.00
IUUC-Pop-099731 Populus trichocarpa 61.75 0.00e+00 2924.00
IUUC-Pca-100655 Procavia capensis 66.23 0.00e+00 1182.00
IUUC-Ppe-101199 Prunus persica 60.07 0.00e+00 2831.00
IUUC-Pva-103175 Pteropus vampyrus 66.38 0.00e+00 2486.00
IUUC-Pgr-103467 Puccinia graminis 59.67 0.00e+00 2795.00
IUUC-Ptt-103770 Puccinia triticina 54.95 0.00e+00 2454.00
IUUC-Pte-104210 Pyrenophora teres 62.44 0.00e+00 3046.00
IUUC-Pyt-104572 Pyrenophora triticirepentis 64.10 0.00e+00 2018.00
IUUC-Rno-105997 Rattus norvegicus 62.21 0.00e+00 2943.00
IUUC-Sha-107355 Sarcophilus harrisii 62.26 0.00e+00 2945.00
IUUC-Sja-107760 Schizosaccharomyces japonicus 62.40 0.00e+00 2980.00
IUUC-Spo-108160 Schizosaccharomyces pombe 62.05 0.00e+00 2982.00
IUUC-Ssl-108519 Sclerotinia sclerotiorum 64.52 0.00e+00 2018.00
IUUC-Smo-109278 Selaginella moellendorffii 61.63 0.00e+00 2924.00
IUUC-Sit-110777 Setaria italica 62.04 0.00e+00 2949.00
IUUC-Sly-110889 Solanum lycopersicum 61.67 0.00e+00 2943.00
IUUC-Stu-112016 Solanum tuberosum 61.67 0.00e+00 2943.00
IUUC-Sar-113245 Sorex araneus 67.41 0.00e+00 1682.00
IUUC-Sbi-114423 Sorghum bicolor 62.50 0.00e+00 1335.00
IUUC-Sre-115077 Sporisorium reilianum 56.80 0.00e+00 2652.00
IUUC-Ssc-116211 Sus scrofa 62.56 0.00e+00 2872.00
IUUC-Tgu-116697 Taeniopygia guttata 62.34 0.00e+00 2949.00
IUUC-Tru-117984 Takifugu rubripes 62.04 0.00e+00 2960.00
IUUC-Tsy-118893 Tarsius syrichta 62.34 0.00e+00 989.00
IUUC-Tni-120620 Tetraodon nigroviridis 63.96 0.00e+00 2273.00
IUUC-Tca-121331 Theobroma cacao 62.08 0.00e+00 2938.00
IUUC-Tre-122031 Trichoderma reesei 62.89 0.00e+00 3048.00
IUUC-Tvi-122603 Trichoderma virens 62.76 0.00e+00 3041.00
IUUC-Tae-125167 Triticum aestivum 62.09 0.00e+00 2942.00
IUUC-Tur-126772 Triticum urartu 62.54 0.00e+00 2935.00
IUUC-Tme-126899 Tuber melanosporum 62.63 0.00e+00 3048.00
IUUC-Tbe-127364 Tupaia belangeri 68.87 0.00e+00 2113.00
IUUC-Ttr-129009 Tursiops truncatus 61.83 0.00e+00 2920.00
IUUC-Vda-130015 Verticillium dahliae 63.46 0.00e+00 2022.00
IUUC-Vpa-130769 Vicugna pacos 68.46 0.00e+00 845.00
IUUC-Vvi-131030 Vitis vinifera 61.82 0.00e+00 2924.00
IUUC-Xtr-132067 Xenopus tropicalis 62.23 0.00e+00 2949.00
IUUC-Xma-134252 Xiphophorus maculatus 62.26 0.00e+00 2962.00
IUUC-Yli-134434 Yarrowia lipolytica 62.52 0.00e+00 3015.00
IUUC-Zma-134994 Zea mays 61.95 0.00e+00 2938.00
Created Date 25-Jun-2017

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