iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.50e-21	73.4	504	540
UBD/Beta-Prp	6.20e-41	140.9	446	646

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ +t l++ +d t +v+ s+D  i  WD  t+++
   Q: 504  GHSSFITHLDWaQDsTCFVTNSGDYEILYWDAATCKQ 540
           8***********888****************877765 PP

UBD/Beta-Prp

   S: 80   dlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee...tlsghdgvvncvvvhpdgnllvsGslDrtvrlWd 165
           d +t++ v + +  ++++  +sfsp+g +l++Gshd+ + v+ +++g    +     sgh+++++++ + +d+ ++v+ s D  +  Wd
   Q: 446  DTDTRDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSrlgKCSGHSSFITHLDWAQDSTCFVTNSGDYEILYWD 534
           8999******************************************99998889999******************************** PP
   S: 166  l.................ktgkllrtl.......tgghtdsvyslsfdsngkelvsgsldgtvklwdlq...tgecvrtlnghtdnvks 227
                             +t++++  +       +g++  +++ ++ +++g+ lvs+++ g+v l+++         +++ gh++ v+ 
   Q: 535  AatckqitsadtvrnvqwATATCVLGFgvfgiwpEGADGTDINAVARSHDGNLLVSADDFGKVHLFSYPccqPRALSHKYGGHSSHVTN 623
           ************************999*******999******************************98776666799*********** PP
   S: 228  vrfs.pnderlvsgssDgsiriW 249
           v+f+ +++  l +g++D s+  W
   Q: 624  VAFLwDDSMVLTTGGKDTSVLQW 646
           ***967777788888*****999 PP

Organism

Rattus norvegicus

Functional Description
(View)

Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

Protein Sequence
(Fasta)

MSSFGTGKTK EVIFSMEEGS VKMFLRGRPV PMLIPDELAP TYSLDTRSEL PSSRLKLDWV 60
YGYRGRDCRA NLYLLPTGEV VYFVASVAVL YSVEEQRQRH YLGHNDDIKC LAVHPDMVTI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCTTCTGT GGCCTCTACG ACACGTCCTC TCTGCTGCAA TACTGCAACG GTGAGAACCC 60
CCTTCTCAGT TCAGACCTGG CCCCGCCCAG GGTGGACCTA CCTCCTCCTG CCCCAACCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR005108--HELP
IPR011041--Quinoprot_gluc/sorb_DH
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03451--HELP
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0072686--C:mitotic spindle
GO:0003824--F:catalytic activity
GO:0008017--F:microtubule binding
GO:0008022--F:protein C-terminus binding
GO:0005102--F:receptor binding
GO:0015631--F:tubulin binding
GO:0031115--P:negative regulation of microtubule polymerization
GO:0010968--P:regulation of microtubule nucleation

KEGG

rno:192360

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002155	Ailuropoda melanoleuca	94.57	0.00e+00	1255.00
IUUC-Aca-005316	Anolis carolinensis	79.32	0.00e+00	1050.00
IUUC-Ame-011647	Astyanax mexicanus	69.95	0.00e+00	983.00
IUUC-Bta-013267	Bos taurus	93.49	0.00e+00	1249.00
IUUC-Cja-019146	Callithrix jacchus	88.54	0.00e+00	1194.00
IUUC-Cfa-020267	Canis familiaris	94.72	0.00e+00	1262.00
IUUC-Cin-025784	Ciona intestinalis	54.49	0.00e+00	741.00
IUUC-Csv-026305	Ciona savignyi	53.41	0.00e+00	722.00
IUUC-Dre-028734	Danio rerio	71.18	0.00e+00	1001.00
IUUC-Dno-028961	Dasypus novemcinctus	91.59	0.00e+00	1191.00
IUUC-Dme-032093	Drosophila melanogaster	35.75	3.00e-111	396.00
IUUC-Eca-033785	Equus caballus	94.08	0.00e+00	1253.00
IUUC-Eeu-035302	Erinaceus europaeus	92.37	0.00e+00	706.00
IUUC-Fca-036170	Felis catus	93.19	0.00e+00	1242.00
IUUC-Gac-042643	Gasterosteus aculeatus	68.67	0.00e+00	951.00
IUUC-Ggo-044669	Gorilla gorilla	92.38	0.00e+00	1233.00
IUUC-Hsa-046141	Homo sapiens	94.24	0.00e+00	1260.00
IUUC-Itr-048788	Ictidomys tridecemlineatus	92.41	0.00e+00	1227.00
IUUC-Loc-052518	Lepisosteus oculatus	70.27	0.00e+00	956.00
IUUC-Laf-054137	Loxodonta africana	88.82	0.00e+00	1168.00
IUUC-Mcc-055780	Macaca mulatta	93.42	0.00e+00	1174.00
IUUC-Meu-056664	Macropus eugenii	82.56	0.00e+00	1116.00
IUUC-Mmr-060853	Microcebus murinus	92.83	0.00e+00	1246.00
IUUC-Mdo-062224	Monodelphis domestica	87.30	0.00e+00	1035.00
IUUC-Mmu-063860	Mus musculus	98.29	0.00e+00	1300.00
IUUC-Mpu-066043	Mustela putorius furo	95.33	0.00e+00	1263.00
IUUC-Mlu-067125	Myotis lucifugus	71.52	0.00e+00	875.00
IUUC-Nle-069618	Nomascus leucogenys	84.01	0.00e+00	1083.00
IUUC-Opr-070228	Ochotona princeps	85.80	0.00e+00	1132.00
IUUC-Ont-071258	Oreochromis niloticus	69.22	0.00e+00	978.00
IUUC-Ocu-074087	Oryctolagus cuniculus	81.50	0.00e+00	846.00
IUUC-Oga-088048	Otolemur garnettii	90.22	0.00e+00	1191.00
IUUC-Oar-089907	Ovis aries	93.61	0.00e+00	1222.00
IUUC-Pan-092082	Papio anubis	93.79	0.00e+00	1248.00
IUUC-Pma-094555	Petromyzon marinus	58.26	0.00e+00	804.00
IUUC-Pfo-096717	Poecilia formosa	68.12	0.00e+00	967.00
IUUC-Pab-097619	Pongo abelii	94.14	0.00e+00	1266.00
IUUC-Pca-101070	Procavia capensis	83.18	0.00e+00	1083.00
IUUC-Pva-102957	Pteropus vampyrus	88.60	0.00e+00	1180.00
IUUC-Sha-106692	Sarcophilus harrisii	87.34	0.00e+00	1180.00
IUUC-Tru-117809	Takifugu rubripes	67.81	0.00e+00	966.00
IUUC-Tni-120815	Tetraodon nigroviridis	68.64	0.00e+00	974.00
IUUC-Ttr-128263	Tursiops truncatus	89.51	0.00e+00	1195.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence