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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105550
UUCD1 version UUC-RaN-00043
Ensembl Protein ID ENSRNOP00000010421.5
UniProt Accession B2GV24; UFL1_RAT
Genbank Protein ID AAI66498.1
Protein Name E3 UFM1-protein ligase 1
Genbank Nucleotide ID BC166498
Gene Name Ufl1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000007831.7 ENSRNOT00000089522.1 ENSRNOP00000072123.1
ENSRNOG00000007831.7 ENSRNOT00000010421.5 ENSRNOP00000010421.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndex
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 90.68 0.00e+00 1336.00 IUUC-Hsa-046823
ULD/UDP/UBQ/UBQ_Other 90.68 0.00e+00 1336.00 IUUC-Hsa-046823
E3 activity/Other 95.84 0.00e+00 1401.00 IUUC-Mmu-064248
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling. May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress.
 E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling. May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress.
Protein Sequence
(Fasta)
MADAWEEIRR LAADFQRAQF AESTQRLSER NCIEIVNKLI SQKQLEVVHT LDGKEYITPA 60
QISKEMRDEL HVRGGRVNIV DLQQVINVDL THIENRVGDI IKSEKHVQMV LGQLVDENYL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105550|E3,E3 activity/Other;ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCTGACGT GTCTGCCGTT TCCCGGTGTC GCGGAGAGCG GAGCAGTGAT GGCGGACGCC 60
TGGGAGGAGA TCCGGCGTCT GGCGGCTGAC TTCCAGCGGG CGCAGTTTGC TGAGTCCACG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105550|E3,E3 activity/Other;ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0436--Ligase
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR018611--E3_UFM1_ligase_1
Pfam

PF09743--DUF2042
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0043005--C:neuron projection
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0071568--F:UFM1 transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001649--P:osteoblast differentiation
GO:0060252--P:positive regulation of glial cell proliferation
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880--P:regulation of protein localization
GO:0034976--P:response to endoplasmic reticulum stress
GO:1902065--P:response to L-glutamate
KEGG rno:313115
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000068 Aegilops tauschii 30.14 3.00e-42 167.00
IUUC-Aml-001894 Ailuropoda melanoleuca 90.68 0.00e+00 1404.00
IUUC-Atr-003137 Amborella trichopoda 32.99 9.00e-55 207.00
IUUC-Apl-003993 Anas platyrhynchos 73.32 0.00e+00 1080.00
IUUC-Aca-004941 Anolis carolinensis 72.87 0.00e+00 854.00
IUUC-Aly-006023 Arabidopsis lyrata 25.94 5.00e-69 255.00
IUUC-Ath-007249 Arabidopsis thaliana 29.32 1.00e-49 191.00
IUUC-Ame-011084 Astyanax mexicanus 70.09 8.00e-134 469.00
IUUC-Bta-012960 Bos taurus 89.67 0.00e+00 1394.00
IUUC-Bdi-014730 Brachypodium distachyon 31.40 4.00e-50 192.00
IUUC-Bol-016306 Brassica oleracea 25.68 3.00e-69 256.00
IUUC-Bra-016735 Brassica rapa 25.94 3.00e-65 243.00
IUUC-Cel-018267 Caenorhabditis elegans 28.61 2.00e-36 147.00
IUUC-Cja-019432 Callithrix jacchus 90.04 0.00e+00 1381.00
IUUC-Cfa-020879 Canis familiaris 88.90 0.00e+00 1361.00
IUUC-Cpo-021915 Cavia porcellus 84.92 0.00e+00 1282.00
IUUC-Cre-022838 Chlamydomonas reinhardtii 42.42 4.00e-22 97.10
IUUC-Csa-023667 Chlorocebus sabaeus 90.55 0.00e+00 1402.00
IUUC-Cin-025254 Ciona intestinalis 40.43 3.00e-179 622.00
IUUC-Csv-026110 Ciona savignyi 41.11 1.00e-173 603.00
IUUC-Cme-027205 Cyanidioschyzon merolae 31.43 2.80e-01 30.00
IUUC-Dre-028832 Danio rerio 62.64 0.00e+00 911.00
IUUC-Dno-029396 Dasypus novemcinctus 84.90 0.00e+00 1260.00
IUUC-Dor-030872 Dipodomys ordii 77.35 9.00e-165 573.00
IUUC-Dme-031860 Drosophila melanogaster 42.86 5.00e-92 332.00
IUUC-Ete-032382 Echinops telfairi 85.52 0.00e+00 1256.00
IUUC-Eca-034175 Equus caballus 85.16 0.00e+00 1350.00
IUUC-Eeu-035073 Erinaceus europaeus 75.00 2.00e-166 578.00
IUUC-Fca-035655 Felis catus 86.48 0.00e+00 1332.00
IUUC-Fal-037594 Ficedula albicollis 72.46 0.00e+00 919.00
IUUC-Fso-038403 Fusarium solani 37.14 6.50e-02 29.60
IUUC-Gmo-038897 Gadus morhua 60.94 0.00e+00 820.00
IUUC-Gga-040147 Gallus gallus 74.43 0.00e+00 1108.00
IUUC-Gac-042365 Gasterosteus aculeatus 62.31 0.00e+00 955.00
IUUC-Gma-044359 Glycine max 32.65 4.00e-43 170.00
IUUC-Ggo-045085 Gorilla gorilla 90.55 0.00e+00 1384.00
IUUC-Hsa-046823 Homo sapiens 90.68 0.00e+00 1384.00
IUUC-Hvu-047672 Hordeum vulgare 27.23 6.00e-72 265.00
IUUC-Itr-048558 Ictidomys tridecemlineatus 90.79 0.00e+00 1382.00
IUUC-Lch-050099 Latimeria chalumnae 70.60 0.00e+00 1108.00
IUUC-Lpe-051353 Leersia perrieri 28.25 2.00e-75 277.00
IUUC-Loc-052237 Lepisosteus oculatus 72.55 0.00e+00 637.00
IUUC-Laf-053535 Loxodonta africana 86.06 0.00e+00 1306.00
IUUC-Mcc-054991 Macaca mulatta 90.43 0.00e+00 1399.00
IUUC-Meu-055924 Macropus eugenii 77.93 2.00e-97 350.00
IUUC-Mtr-058527 Medicago truncatula 28.62 1.00e-57 218.00
IUUC-Mga-059514 Meleagris gallopavo 74.59 0.00e+00 1100.00
IUUC-Mmr-061625 Microcebus murinus 90.42 0.00e+00 1408.00
IUUC-Mdo-062551 Monodelphis domestica 81.86 0.00e+00 1247.00
IUUC-Mmu-064248 Mus musculus 95.84 0.00e+00 1434.00
IUUC-Mac-065571 Musa acuminata 32.51 3.00e-56 213.00
IUUC-Mpu-065883 Mustela putorius furo 89.80 0.00e+00 1390.00
IUUC-Mlu-067468 Myotis lucifugus 88.16 0.00e+00 1369.00
IUUC-Nle-069831 Nomascus leucogenys 90.68 0.00e+00 1402.00
IUUC-Opr-071153 Ochotona princeps 68.92 0.00e+00 847.00
IUUC-Ont-072677 Oreochromis niloticus 64.79 0.00e+00 978.00
IUUC-Oan-073682 Ornithorhynchus anatinus 75.63 0.00e+00 1086.00
IUUC-Ocu-074268 Oryctolagus cuniculus 90.92 0.00e+00 1418.00
IUUC-Oba-075467 Oryza barthii 28.17 2.00e-74 274.00
IUUC-Obr-076760 Oryza brachyantha 28.57 1.00e-73 271.00
IUUC-Ogl-077088 Oryza glaberrima 28.15 8.00e-74 271.00
IUUC-Ogu-078509 Oryza glumaepatula 27.92 2.00e-74 273.00
IUUC-Oin-079276 Oryza indica 28.21 8.00e-76 278.00
IUUC-Olo-080814 Oryza longistaminata 28.29 8.00e-75 275.00
IUUC-Ome-081647 Oryza meridionalis 28.21 1.00e-72 268.00
IUUC-Oni-082954 Oryza nivara 28.04 2.00e-74 273.00
IUUC-Opu-083580 Oryza punctata 27.15 2.00e-65 243.00
IUUC-Oru-084627 Oryza rufipogon 28.21 8.00e-76 278.00
IUUC-Osa-086096 Oryza sativa 28.21 8.00e-76 278.00
IUUC-Ola-087322 Oryzias latipes 62.01 0.00e+00 977.00
IUUC-Olu-087693 Ostreococcus lucimarinus 26.28 2.00e-19 90.90
IUUC-Oga-088769 Otolemur garnettii 86.15 0.00e+00 1328.00
IUUC-Oar-090007 Ovis aries 89.31 0.00e+00 1384.00
IUUC-Ptr-090760 Pan troglodytes 90.30 0.00e+00 1378.00
IUUC-Pan-092162 Papio anubis 90.68 0.00e+00 1400.00
IUUC-Psi-093045 Pelodiscus sinensis 76.01 0.00e+00 1097.00
IUUC-Ppa-095424 Physcomitrella patens 33.77 9.00e-57 215.00
IUUC-Pfo-096108 Poecilia formosa 62.48 0.00e+00 962.00
IUUC-Pab-098057 Pongo abelii 87.78 0.00e+00 1347.00
IUUC-Pop-099790 Populus trichocarpa 26.47 5.00e-60 226.00
IUUC-Pca-100307 Procavia capensis 84.13 0.00e+00 1284.00
IUUC-Ppe-102029 Prunus persica 30.79 2.00e-53 204.00
IUUC-Pva-102386 Pteropus vampyrus 85.88 0.00e+00 843.00
IUUC-Sha-107442 Sarcophilus harrisii 82.62 0.00e+00 1250.00
IUUC-Smo-109447 Selaginella moellendorffii 32.82 2.00e-55 210.00
IUUC-Sit-110568 Setaria italica 31.86 5.00e-50 192.00
IUUC-Sly-111028 Solanum lycopersicum 31.62 1.00e-49 191.00
IUUC-Stu-112317 Solanum tuberosum 31.11 7.00e-48 185.00
IUUC-Sar-113662 Sorex araneus 82.29 0.00e+00 1250.00
IUUC-Sbi-114636 Sorghum bicolor 31.97 7.00e-51 195.00
IUUC-Ssc-116423 Sus scrofa 89.67 0.00e+00 1383.00
IUUC-Tgu-116977 Taeniopygia guttata 72.76 0.00e+00 1102.00
IUUC-Tru-118314 Takifugu rubripes 61.05 0.00e+00 941.00
IUUC-Tsy-119391 Tarsius syrichta 87.39 0.00e+00 1332.00
IUUC-Tni-120594 Tetraodon nigroviridis 63.20 0.00e+00 931.00
IUUC-Tca-121351 Theobroma cacao 27.18 2.00e-63 237.00
IUUC-Tae-122849 Triticum aestivum 29.18 5.00e-22 99.80
IUUC-Tur-126308 Triticum urartu 29.18 7.00e-22 99.40
IUUC-Tbe-127999 Tupaia belangeri 89.16 0.00e+00 1268.00
IUUC-Ttr-129189 Tursiops truncatus 82.35 0.00e+00 1268.00
IUUC-Vpa-130734 Vicugna pacos 84.62 0.00e+00 1288.00
IUUC-Vvi-131695 Vitis vinifera 29.78 2.00e-50 194.00
IUUC-Xtr-132004 Xenopus tropicalis 63.09 0.00e+00 940.00
IUUC-Xma-134108 Xiphophorus maculatus 61.05 0.00e+00 840.00
IUUC-Zma-135513 Zea mays 31.86 5.00e-50 192.00
Created Date 25-Jun-2017

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