iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054715

Ensembl Protein ID

ENSMMUP00000018960.2

UniProt Accession

F7BHF8; F7BHF8_MACMU

Genbank Protein ID

AFH31507.1; EHH14509.1

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

JSUE03000812; CM001253

Gene Name

FGR; EGK_00444

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000014434.3	ENSMMUT00000020255.3	ENSMMUP00000018960.2
ENSMMUG00000014434.3	ENSMMUT00000074018.1	ENSMMUP00000050452.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.10e-16	59.0	81	137

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++lydyea ++d+Lt++kG++ +++  ++++++W+++ +  +g+ G +P+n+v+ ++
   Q: 81   LFIALYDYEARTEDDLTFTKGEKFHIL--NNTEGDWWEARSLSSGQTGYIPSNYVAPVD 137
           5789***********************..8999**********************9987 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MGCVYCKKLE PAATAKEDAG LEGDFRSYGA ADHYGPDPTK AQPASSFVHI PNYSNFSSQA 60
INPGFLDGGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCCAGTTC TCCCCGCACG CCGGCACTCG CGGCTGCTGG AGCCCCGGCT GGCTCGCTCC 60
GGGGCCAGGC AGAATTTGGC TCCAGGTAAG AGACCGCGTC GGGTGGGGGC TGGGCAGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0050830--P:defense response to Gram-positive bacterium
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0030335--P:positive regulation of cell migration
GO:0050715--P:positive regulation of cytokine secretion
GO:0043306--P:positive regulation of mast cell degranulation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0045088--P:regulation of innate immune response
GO:0050764--P:regulation of phagocytosis
GO:0045859--P:regulation of protein kinase activity
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mcc:716296

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001938	Ailuropoda melanoleuca	89.79	0.00e+00	999.00
IUUC-Bta-012607	Bos taurus	90.17	0.00e+00	1006.00
IUUC-Cja-018914	Callithrix jacchus	91.11	0.00e+00	1006.00
IUUC-Cfa-020165	Canis familiaris	89.04	0.00e+00	993.00
IUUC-Cpo-021476	Cavia porcellus	88.85	0.00e+00	970.00
IUUC-Csa-023692	Chlorocebus sabaeus	98.68	0.00e+00	1093.00
IUUC-Dno-028920	Dasypus novemcinctus	86.77	0.00e+00	965.00
IUUC-Eca-033581	Equus caballus	90.93	0.00e+00	1014.00
IUUC-Fca-036499	Felis catus	89.60	0.00e+00	1005.00
IUUC-Ggo-044640	Gorilla gorilla	97.35	0.00e+00	1081.00
IUUC-Hsa-046751	Homo sapiens	97.54	0.00e+00	1083.00
IUUC-Itr-048218	Ictidomys tridecemlineatus	89.41	0.00e+00	985.00
IUUC-Laf-054128	Loxodonta africana	87.15	0.00e+00	980.00
IUUC-Meu-056155	Macropus eugenii	82.52	0.00e+00	782.00
IUUC-Mmr-060615	Microcebus murinus	90.24	0.00e+00	989.00
IUUC-Mmu-063286	Mus musculus	83.93	0.00e+00	931.00
IUUC-Mpu-066641	Mustela putorius furo	89.22	0.00e+00	997.00
IUUC-Oan-073486	Ornithorhynchus anatinus	76.94	0.00e+00	860.00
IUUC-Ocu-074552	Oryctolagus cuniculus	88.83	0.00e+00	963.00
IUUC-Oga-088731	Otolemur garnettii	90.36	0.00e+00	1008.00
IUUC-Oar-090207	Ovis aries	90.17	0.00e+00	1001.00
IUUC-Ptr-090979	Pan troglodytes	97.54	0.00e+00	1083.00
IUUC-Pan-092188	Papio anubis	99.43	0.00e+00	1103.00
IUUC-Pab-098617	Pongo abelii	97.54	0.00e+00	1087.00
IUUC-Pca-100834	Procavia capensis	78.64	0.00e+00	838.00
IUUC-Rno-104945	Rattus norvegicus	84.88	0.00e+00	925.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence