iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-068185

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02030735

Gene Name

TRIM25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000010740.2	ENSMLUT00000010738.2	ENSMLUP00000009789.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.80e-08	34.2	13	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle fk  p+++pCgH f+ +Cl + w     ++   f+CP Cr
   Q: 13   CSICLELFKV-PVTTPCGHNFCGSCLdETW----TVQGAPFQCPQCR 54
           ********88.*******************....999*********8 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

LSEYMSLAEE LTCSICLELF KVPVTTPCGH NFCGSCLDET WTVQGAPFQC PQCRTEYPAR 60
PQLRKNTVLC TVVEQFAQAE LARATAPDDW TPPSRAAAPS PTGQVACDHC LKAAAIKTCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTATCTGAGT ATATGTGAGA GAAAAACCTT TGTTAAACTG GGATGTCGCC AAACCCTAGT 60
AAAGTAGAAC TGGAAATTTA AAAAAAAAAA AAATCATGTT AATCGCGGTG GAAAGAAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0003723--F:RNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002424	Ailuropoda melanoleuca	73.66	0.00e+00	936.00
IUUC-Apl-004101	Anas platyrhynchos	48.98	4.00e-165	574.00
IUUC-Aca-005025	Anolis carolinensis	47.71	3.00e-170	591.00
IUUC-Ame-011586	Astyanax mexicanus	27.51	8.00e-58	218.00
IUUC-Bta-012735	Bos taurus	74.61	0.00e+00	954.00
IUUC-Cja-019996	Callithrix jacchus	70.22	1.00e-178	619.00
IUUC-Cfa-020466	Canis familiaris	71.90	0.00e+00	913.00
IUUC-Cpo-021737	Cavia porcellus	66.88	0.00e+00	849.00
IUUC-Cre-022560	Chlamydomonas reinhardtii	45.45	2.00e-06	47.80
IUUC-Csa-023217	Chlorocebus sabaeus	76.90	0.00e+00	957.00
IUUC-Cho-024346	Choloepus hoffmanni	50.83	3.00e-71	261.00
IUUC-Dno-030082	Dasypus novemcinctus	73.70	0.00e+00	930.00
IUUC-Dor-030335	Dipodomys ordii	51.27	4.00e-121	428.00
IUUC-Ete-032923	Echinops telfairi	68.16	0.00e+00	771.00
IUUC-Eca-033411	Equus caballus	73.43	0.00e+00	934.00
IUUC-Eeu-034656	Erinaceus europaeus	71.51	3.00e-160	558.00
IUUC-Fca-035371	Felis catus	72.46	0.00e+00	936.00
IUUC-Fal-037008	Ficedula albicollis	47.38	3.00e-160	558.00
IUUC-Gmo-038668	Gadus morhua	33.86	2.00e-104	372.00
IUUC-Gga-040608	Gallus gallus	49.12	8.00e-164	570.00
IUUC-Gac-041409	Gasterosteus aculeatus	35.96	1.00e-116	414.00
IUUC-Ggo-044518	Gorilla gorilla	77.80	0.00e+00	932.00
IUUC-Hsa-045828	Homo sapiens	77.53	0.00e+00	962.00
IUUC-Itr-049070	Ictidomys tridecemlineatus	70.82	5.00e-136	477.00
IUUC-Lch-050478	Latimeria chalumnae	40.33	2.00e-71	263.00
IUUC-Loc-052864	Lepisosteus oculatus	37.52	5.00e-114	405.00
IUUC-Laf-054325	Loxodonta africana	72.83	1.00e-162	565.00
IUUC-Mcc-054920	Macaca mulatta	77.37	0.00e+00	961.00
IUUC-Meu-056367	Macropus eugenii	71.68	1.00e-72	267.00
IUUC-Mga-059975	Meleagris gallopavo	49.37	6.00e-165	574.00
IUUC-Mmr-060748	Microcebus murinus	74.65	0.00e+00	918.00
IUUC-Mdo-062904	Monodelphis domestica	57.05	0.00e+00	677.00
IUUC-Mmu-063891	Mus musculus	69.18	0.00e+00	900.00
IUUC-Mpu-066473	Mustela putorius furo	74.88	0.00e+00	963.00
IUUC-Nle-070177	Nomascus leucogenys	77.85	0.00e+00	961.00
IUUC-Opr-070558	Ochotona princeps	59.29	7.00e-144	503.00
IUUC-Ont-071368	Oreochromis niloticus	37.29	3.00e-110	392.00
IUUC-Ocu-074461	Oryctolagus cuniculus	67.62	3.00e-151	528.00
IUUC-Ola-087315	Oryzias latipes	25.20	1.00e-55	210.00
IUUC-Oga-088937	Otolemur garnettii	69.92	0.00e+00	867.00
IUUC-Oar-089781	Ovis aries	75.90	0.00e+00	652.00
IUUC-Ptr-090771	Pan troglodytes	77.22	0.00e+00	940.00
IUUC-Pan-092830	Papio anubis	77.37	0.00e+00	962.00
IUUC-Psi-093664	Pelodiscus sinensis	52.38	2.00e-176	612.00
IUUC-Pma-094147	Petromyzon marinus	27.62	2.00e-64	240.00
IUUC-Pfo-096906	Poecilia formosa	26.11	6.00e-62	231.00
IUUC-Pab-097588	Pongo abelii	75.16	0.00e+00	940.00
IUUC-Pca-100890	Procavia capensis	71.43	2.00e-155	542.00
IUUC-Pva-102314	Pteropus vampyrus	80.38	0.00e+00	988.00
IUUC-Rno-105234	Rattus norvegicus	66.87	0.00e+00	872.00
IUUC-Sce-106362	Saccharomyces cerevisiae	44.62	7.00e-10	58.20
IUUC-Sha-106807	Sarcophilus harrisii	54.23	0.00e+00	657.00
IUUC-Sar-113283	Sorex araneus	58.11	7.00e-136	477.00
IUUC-Ssc-115878	Sus scrofa	80.26	2.00e-107	381.00
IUUC-Tgu-117026	Taeniopygia guttata	45.02	2.00e-125	442.00
IUUC-Tru-118191	Takifugu rubripes	30.03	1.00e-34	141.00
IUUC-Tni-120550	Tetraodon nigroviridis	26.61	2.00e-64	239.00
IUUC-Tbe-127580	Tupaia belangeri	69.01	8.00e-149	520.00
IUUC-Ttr-128648	Tursiops truncatus	69.98	0.00e+00	642.00
IUUC-Vpa-130254	Vicugna pacos	86.86	2.00e-96	346.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence