iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042456

UUCD1 version

UUC-GaA-00081

Ensembl Protein ID

ENSGACP00000002183.1

UniProt Accession

G3NA41; G3NA41_GASAC

Protein Name

Uncharacterized protein

Gene Name

HECW2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000001668.1	ENSGACT00000002189.1	ENSGACP00000002183.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-120	402.9	1196	1528

Active Site

Position(s)	Description	Evidence
1496	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgE+gld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al+++ lld
   Q: 1196 DLQRSKLYVSFVGEDGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALVHQYLLD 1281
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   die++ ldltf+v+ee++g+++e+eLkpgG+ ipV ++Nk+eY+++
   Q: 1282 AFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDN---DIEDM-LDLTFTVNEEVFGQITERELKPGGAGIPVSEKNKKEYIER 1364
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+++q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid+ d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1365 MVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEIDLADWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1451
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lP+++TCfn+L+LP+Y+s + l+ekL +A+eet+ F+l+
   Q: 1452 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKLVTAVEETSTFGLE 1528
           **************************************************************************985 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

LAVGGREHLS APRRRSPHLR HTLSPDNLRT LAERGGASVD AVSVISSPVG LPRANSDTDL 60
VTSQSRSSLT ASTLEYTLGR GHNLVISWDI KEEVDATDWI GLYHIDESNP SNVWDCKNRG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGCAGTTG GGGGCCGGGA ACACCTGTCA GCTCCACGCA GGCGCAGCCC CCACCTCCGG 60
CACACCCTCA GCCCAGATAA CCTGCGGACC CTGGCGGAGC GAGGCGGAGC CTCCGTCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	64.53	0.00e+00	1899.00
IUUC-Aca-004558	Anolis carolinensis	63.82	0.00e+00	1878.00
IUUC-Cja-019651	Callithrix jacchus	64.94	0.00e+00	1824.00
IUUC-Csa-023970	Chlorocebus sabaeus	64.38	0.00e+00	1875.00
IUUC-Dno-029963	Dasypus novemcinctus	64.84	0.00e+00	1812.00
IUUC-Dor-030282	Dipodomys ordii	52.19	0.00e+00	985.00
IUUC-Fca-036157	Felis catus	64.37	0.00e+00	1883.00
IUUC-Gmo-039291	Gadus morhua	73.33	0.00e+00	1338.00
IUUC-Gga-040821	Gallus gallus	64.00	0.00e+00	1901.00
IUUC-Ggo-044862	Gorilla gorilla	64.60	0.00e+00	1810.00
IUUC-Hsa-046219	Homo sapiens	64.07	0.00e+00	1903.00
IUUC-Laf-054005	Loxodonta africana	64.71	0.00e+00	1893.00
IUUC-Mcc-055314	Macaca mulatta	64.19	0.00e+00	1875.00
IUUC-Meu-056751	Macropus eugenii	73.46	0.00e+00	708.00
IUUC-Mga-060074	Meleagris gallopavo	63.41	0.00e+00	1823.00
IUUC-Mdo-063017	Monodelphis domestica	65.05	0.00e+00	1884.00
IUUC-Mmu-064165	Mus musculus	64.77	0.00e+00	1894.00
IUUC-Mlu-067709	Myotis lucifugus	63.43	0.00e+00	1842.00
IUUC-Nle-069308	Nomascus leucogenys	64.22	0.00e+00	1887.00
IUUC-Ont-071918	Oreochromis niloticus	84.52	0.00e+00	2511.00
IUUC-Ocu-074775	Oryctolagus cuniculus	64.29	0.00e+00	1689.00
IUUC-Ola-087225	Oryzias latipes	80.46	0.00e+00	2387.00
IUUC-Oar-089452	Ovis aries	64.15	0.00e+00	1889.00
IUUC-Ptr-090806	Pan troglodytes	64.20	0.00e+00	1889.00
IUUC-Pan-091838	Papio anubis	64.54	0.00e+00	1801.00
IUUC-Psi-094090	Pelodiscus sinensis	64.31	0.00e+00	1908.00
IUUC-Pab-098405	Pongo abelii	64.13	0.00e+00	1882.00
IUUC-Pca-100441	Procavia capensis	55.53	0.00e+00	1276.00
IUUC-Rno-105943	Rattus norvegicus	64.39	0.00e+00	1920.00
IUUC-Ssc-115439	Sus scrofa	55.22	0.00e+00	1019.00
IUUC-Tru-118706	Takifugu rubripes	92.43	0.00e+00	1493.00
IUUC-Tni-120069	Tetraodon nigroviridis	75.93	0.00e+00	2255.00
IUUC-Tbe-127975	Tupaia belangeri	57.93	0.00e+00	1397.00
IUUC-Ttr-128469	Tursiops truncatus	59.58	0.00e+00	1675.00
IUUC-Vpa-130498	Vicugna pacos	56.37	0.00e+00	1518.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence