iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046219

UUCD1 version

UUC-HoS-01266

Ensembl Protein ID

ENSP00000260983.2

UniProt Accession

Q9P2P5; B8ZZB4; Q17RT5; Q68DF8; Q9NPS9; HECW2_HUMAN

Genbank Protein ID

BAA92539.1; CAB99103.1; CAH18262.1; AAI17195.1; AAI17199.1

Protein Name

E3 ubiquitin-protein ligase HECW2; HECT, C2 and WW domain-containing protein 2; HECT-type E3 ubiquitin transferase HECW2; NEDD4-like E3 ubiquitin-protein ligase 2

Genbank Nucleotide ID

AB037722; AL390186; CR749424; AC020571; BC117198

Gene Name

HECW2; KIAA1301; NEDL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000138411.10	ENST00000260983.7	ENSP00000260983.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	12890487; 18418053

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	3.20e-121	406.5	1240	1572

Active Site

Position(s)	Description	Evidence
1540	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld+++
   Q: 1240 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLDAFF 1328
           456689****************************************************985.5*************************** PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrl 182
           +++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY++++v++r+
   Q: 1329 TRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRI 1414
           *********************************99...9***9.********************************************** PP
   S: 183  kegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgss 272
           ++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r ++LqFvTg+s
   Q: 1415 ERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTS 1504
           ****************************************************************************************** PP
   S: 273  rlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           ++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1505 SIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
           *****************************************************************985 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370).

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MTLQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCTTCCGC ACCTTCCTCA GGGAGGTCCC GCTGGCCAAG GTCTGGCTGT CCCTCCTGTC 60
CTCTGCCCCC GCCTCCCTTC CACCGGTCCC CGACGTGCCG CCAGCTCCCA GCCCAGCGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

hsa:57520

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	96.88	0.00e+00	2985.00
IUUC-Apl-003935	Anas platyrhynchos	85.63	0.00e+00	2726.00
IUUC-Aca-004558	Anolis carolinensis	83.86	0.00e+00	2662.00
IUUC-Ame-010893	Astyanax mexicanus	88.33	0.00e+00	1307.00
IUUC-Bta-013093	Bos taurus	96.47	0.00e+00	1586.00
IUUC-Cja-019651	Callithrix jacchus	97.55	0.00e+00	2917.00
IUUC-Cfa-021232	Canis familiaris	99.49	0.00e+00	1637.00
IUUC-Cpo-021770	Cavia porcellus	89.33	0.00e+00	2811.00
IUUC-Csa-023970	Chlorocebus sabaeus	99.17	0.00e+00	3013.00
IUUC-Cho-024512	Choloepus hoffmanni	89.25	0.00e+00	2631.00
IUUC-Csv-026127	Ciona savignyi	66.67	4.00e-155	540.00
IUUC-Dre-028275	Danio rerio	85.26	0.00e+00	1485.00
IUUC-Dno-029963	Dasypus novemcinctus	95.10	0.00e+00	2793.00
IUUC-Dor-030282	Dipodomys ordii	90.96	0.00e+00	2010.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	659.00
IUUC-Ete-033132	Echinops telfairi	83.31	0.00e+00	1266.00
IUUC-Eca-033978	Equus caballus	96.18	0.00e+00	2926.00
IUUC-Eeu-035278	Erinaceus europaeus	64.09	0.00e+00	1202.00
IUUC-Fca-036157	Felis catus	96.63	0.00e+00	2944.00
IUUC-Fal-037110	Ficedula albicollis	89.11	0.00e+00	1729.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1017.00
IUUC-Gga-040821	Gallus gallus	85.92	0.00e+00	2719.00
IUUC-Gac-042456	Gasterosteus aculeatus	64.09	0.00e+00	1890.00
IUUC-Ggo-044862	Gorilla gorilla	99.74	0.00e+00	2941.00
IUUC-Lch-050526	Latimeria chalumnae	78.02	0.00e+00	2436.00
IUUC-Loc-052648	Lepisosteus oculatus	79.22	0.00e+00	1537.00
IUUC-Laf-054005	Loxodonta africana	96.25	0.00e+00	2983.00
IUUC-Mcc-055314	Macaca mulatta	99.24	0.00e+00	3006.00
IUUC-Meu-056356	Macropus eugenii	70.39	0.00e+00	1144.00
IUUC-Mga-060074	Meleagris gallopavo	85.69	0.00e+00	2616.00
IUUC-Mmr-061526	Microcebus murinus	96.76	0.00e+00	2947.00
IUUC-Mdo-063017	Monodelphis domestica	92.13	0.00e+00	2833.00
IUUC-Mmu-064165	Mus musculus	94.68	0.00e+00	2901.00
IUUC-Mpu-065835	Mustela putorius furo	82.74	0.00e+00	1578.00
IUUC-Mlu-067709	Myotis lucifugus	90.20	0.00e+00	2773.00
IUUC-Nle-069308	Nomascus leucogenys	99.43	0.00e+00	3059.00
IUUC-Opr-070330	Ochotona princeps	82.82	0.00e+00	2423.00
IUUC-Ont-071345	Oreochromis niloticus	75.51	0.00e+00	1467.00
IUUC-Ocu-074775	Oryctolagus cuniculus	95.49	0.00e+00	2640.00
IUUC-Ola-087225	Oryzias latipes	72.59	0.00e+00	1365.00
IUUC-Oga-088177	Otolemur garnettii	94.54	0.00e+00	2826.00
IUUC-Oar-089452	Ovis aries	96.44	0.00e+00	2940.00
IUUC-Ptr-090806	Pan troglodytes	99.55	0.00e+00	3088.00
IUUC-Pan-091838	Papio anubis	99.07	0.00e+00	2890.00
IUUC-Psi-094090	Pelodiscus sinensis	85.78	0.00e+00	2704.00
IUUC-Pfo-096520	Poecilia formosa	69.38	0.00e+00	1535.00
IUUC-Pab-098405	Pongo abelii	99.62	0.00e+00	3058.00
IUUC-Pca-100441	Procavia capensis	89.99	0.00e+00	2270.00
IUUC-Pva-102324	Pteropus vampyrus	99.12	0.00e+00	1632.00
IUUC-Rno-105943	Rattus norvegicus	94.30	0.00e+00	2990.00
IUUC-Sha-106985	Sarcophilus harrisii	87.92	0.00e+00	2364.00
IUUC-Sar-113505	Sorex araneus	95.58	0.00e+00	1545.00
IUUC-Ssc-115439	Sus scrofa	95.34	0.00e+00	1950.00
IUUC-Tgu-117078	Taeniopygia guttata	91.13	0.00e+00	1767.00
IUUC-Tru-118706	Takifugu rubripes	82.32	0.00e+00	1370.00
IUUC-Tsy-119498	Tarsius syrichta	98.32	0.00e+00	710.00
IUUC-Tni-120069	Tetraodon nigroviridis	64.89	0.00e+00	1877.00
IUUC-Tbe-127975	Tupaia belangeri	94.07	0.00e+00	2449.00
IUUC-Ttr-128469	Tursiops truncatus	91.28	0.00e+00	2665.00
IUUC-Vpa-130498	Vicugna pacos	85.96	0.00e+00	2453.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence