iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049766

Ensembl Protein ID

ENSLACP00000021632.1

UniProt Accession

H3BIB1; H3BIB1_LATCH

Genbank Protein ID

ENSLACP00000021632

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

AFYH01004081

Gene Name

PLCG1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000019007.1	ENSLACT00000021773.1	ENSLACP00000021632.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.30e-12	46.0	719	775

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekl 62
           k  v++lydy+aq +deL+++k  +++ +  e+q++gW+kg  +  gk+ l fP+n++e+l
   Q: 719  KCAVKALYDYKAQREDELSFTKKAIIQNV--EKQEGGWWKG--DYGGKKQLwFPANYIEEL 775
           5679************************9..9*********..676666655*******98 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

VDIREIKEIR SGRNSRDFER YQEDASFKPD LTHCFVILYG TEFRLKTLSL AATSEEEVEM 60
WTAGLNWLVT DTLKSSTPLQ TERWLRKQFY SVDRNREEKI SSKDLKNMLS QVNYRVPNMK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGATATTC GTGAGATCAA AGAAATTCGT TCTGGAAGAA ACTCCCGAGA CTTTGAGCGA 60
TATCAGGAAG ATGCATCCTT CAAGCCAGAC CTGACACATT GCTTTGTGAT TTTATATGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0001525--P:angiogenesis
GO:0048844--P:artery morphogenesis
GO:0031101--P:fin regeneration
GO:0030851--P:granulocyte differentiation
GO:0060218--P:hematopoietic stem cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0009395--P:phospholipid catabolic process
GO:0035477--P:regulation of angioblast cell migration involved in selective angioblast sprouting
GO:0008016--P:regulation of heart contraction
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	80.00	0.00e+00	2029.00
IUUC-Aca-005291	Anolis carolinensis	80.48	0.00e+00	1994.00
IUUC-Ame-011004	Astyanax mexicanus	69.70	0.00e+00	1705.00
IUUC-Bta-012660	Bos taurus	80.07	0.00e+00	2018.00
IUUC-Cja-019206	Callithrix jacchus	79.82	0.00e+00	2012.00
IUUC-Cfa-020257	Canis familiaris	80.00	0.00e+00	2026.00
IUUC-Cpo-022391	Cavia porcellus	76.14	0.00e+00	1890.00
IUUC-Csa-024170	Chlorocebus sabaeus	81.16	0.00e+00	1468.00
IUUC-Cin-025520	Ciona intestinalis	48.01	0.00e+00	1061.00
IUUC-Dre-027944	Danio rerio	73.47	0.00e+00	1843.00
IUUC-Dno-029440	Dasypus novemcinctus	79.56	0.00e+00	1933.00
IUUC-Dor-031001	Dipodomys ordii	79.19	0.00e+00	2006.00
IUUC-Eca-033809	Equus caballus	80.16	0.00e+00	2029.00
IUUC-Eeu-035329	Erinaceus europaeus	50.04	0.00e+00	1078.00
IUUC-Fca-036510	Felis catus	80.00	0.00e+00	2027.00
IUUC-Fal-037541	Ficedula albicollis	81.13	0.00e+00	1940.00
IUUC-Gmo-038630	Gadus morhua	69.98	0.00e+00	1410.00
IUUC-Gga-040142	Gallus gallus	81.06	0.00e+00	2026.00
IUUC-Ggo-045063	Gorilla gorilla	80.08	0.00e+00	2027.00
IUUC-Hsa-046428	Homo sapiens	80.00	0.00e+00	2024.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	79.75	0.00e+00	2019.00
IUUC-Loc-052285	Lepisosteus oculatus	79.41	0.00e+00	1992.00
IUUC-Laf-053365	Loxodonta africana	79.42	0.00e+00	2013.00
IUUC-Mcc-054871	Macaca mulatta	79.75	0.00e+00	2016.00
IUUC-Meu-056724	Macropus eugenii	75.62	0.00e+00	1855.00
IUUC-Mga-059329	Meleagris gallopavo	80.00	0.00e+00	1988.00
IUUC-Mmr-061110	Microcebus murinus	79.65	0.00e+00	2015.00
IUUC-Mdo-062448	Monodelphis domestica	80.16	0.00e+00	2028.00
IUUC-Mmu-063565	Mus musculus	79.39	0.00e+00	2016.00
IUUC-Mpu-066683	Mustela putorius furo	79.84	0.00e+00	2026.00
IUUC-Mlu-067779	Myotis lucifugus	79.84	0.00e+00	2023.00
IUUC-Nle-069219	Nomascus leucogenys	81.52	0.00e+00	1794.00
IUUC-Opr-070766	Ochotona princeps	77.25	0.00e+00	1217.00
IUUC-Ont-072524	Oreochromis niloticus	76.20	0.00e+00	1924.00
IUUC-Oan-073214	Ornithorhynchus anatinus	78.26	1.00e-40	158.00
IUUC-Ocu-074361	Oryctolagus cuniculus	79.08	0.00e+00	1993.00
IUUC-Ola-086820	Oryzias latipes	73.77	0.00e+00	1893.00
IUUC-Oga-088172	Otolemur garnettii	80.33	0.00e+00	2031.00
IUUC-Oar-090306	Ovis aries	78.15	0.00e+00	1960.00
IUUC-Ptr-090682	Pan troglodytes	80.00	0.00e+00	2026.00
IUUC-Pan-092835	Papio anubis	81.16	0.00e+00	1541.00
IUUC-Psi-093344	Pelodiscus sinensis	79.74	0.00e+00	1992.00
IUUC-Pfo-096984	Poecilia formosa	73.77	0.00e+00	1855.00
IUUC-Pab-097871	Pongo abelii	80.00	0.00e+00	2028.00
IUUC-Pca-100772	Procavia capensis	73.58	0.00e+00	1827.00
IUUC-Pva-102790	Pteropus vampyrus	80.57	0.00e+00	1997.00
IUUC-Rno-105974	Rattus norvegicus	79.59	0.00e+00	2020.00
IUUC-Sar-112995	Sorex araneus	78.21	0.00e+00	1978.00
IUUC-Ssc-115360	Sus scrofa	79.42	0.00e+00	2014.00
IUUC-Tgu-116585	Taeniopygia guttata	79.09	0.00e+00	1930.00
IUUC-Tru-117742	Takifugu rubripes	76.27	0.00e+00	1949.00
IUUC-Tsy-119259	Tarsius syrichta	83.29	0.00e+00	737.00
IUUC-Tbe-127504	Tupaia belangeri	69.75	0.00e+00	1151.00
IUUC-Ttr-128392	Tursiops truncatus	47.47	0.00e+00	1068.00
IUUC-Xtr-132862	Xenopus tropicalis	73.77	0.00e+00	1802.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence