iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000018504.3	ENSXETT00000054943.2	ENSXETP00000054943.2
ENSXETG00000018504.3	ENSXETT00000040057.3	ENSXETP00000040057.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.90e-89	300.2	932	1443

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ f+eql++ + +f      y+++           +++w +ei  + +++ll+l  +l++ + +++ +++r+l++++++    
   Q: 932  PTFWPVFKEQLCRRTFLF------YTSR-----------AHSWGQEIRGK-RENLLQLFRRLNRTLTHEQEFADRFLPDDEAA---- 996
           589***************......****...........**********9.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++++++Ea+  + +q +++++   ++   + +++Yl++v  + +++++ + + ++++++t+Ll++v++ l           
   Q: 997  ----QALGRTCWEALIAPLVQSITTPDPGGMSPLhWLLTKYLENVRLSRRPKSRSSVFNSRVRRLTHLLVHVDSSLPD--------- 1070
           ....******************************9***************************************9988......... PP
   S: 243  lval.lrdkktedlsrmykLlsrvln....gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndak 324
            +al + +k +e+  +  +L ++++     ++  ++++++ ++++q++++l+ +++++d    V+r+++l+ +l ++++e+F++++ 
   Q: 1071 TEALkPPSKTNEKSPDSASLPTKGTVsllsTMTGIAECWQGVVQKQVQRFLEVSWNNTD---LVPRFCSLYLELRQAMEELFGQQTL 1154
           333314455667777888888887766566889999***********************...************************* PP
   S: 325  FlkaldkafetfvnknsvlkaakspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgk 408
           Fl +l+++f + +++ s+l+a +  E++AryiD ++++ s    + + + +l+++l+ + ++s++++   Fe++Y+++La+RLls  
   Q: 1155 FLLSLRQGFCEGLLQLSFLTALHITEQFARYIDCRIQEISTDYYNLQALGHLQQFLEFVLFLSDLELansFEHFYRHYLADRLLS-- 1239
           *************************************************************************************.. PP
   S: 409  sasseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk....................eekent...eesesvelsvlvL 471
              s++E sv+  +    g++f+++  ++M+++l+   dl+r+ +                    ee+e+       e++++ ++vL
   Q: 1240 LGPSWLESSVVDHI----GICFPNRFpQQMLKNLQEASDLQREQHlfclqemdtgllsdeegedmEEEESIgvgHLGEEPKVHISVL 1322
           **************....********************************************997333333111345899******* PP
   S: 472  sagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLaf 546
           s+++W+    + +  ++   P+ l++ ++ f+ fY        ++  + R+LqW++ lg+a+++     g  +lqVst+Qm +LL+f
   Q: 1323 SPRCWAIPslCYMkdPTKYFPESLCRPLNCFKDFYtksqslqgSDLTQRRRLQWTW-LGNADVQY----GSLTLQVSTLQMFILLQF 1404
           *****9877776666999*****************9999999989999********.********....****************** PP
   S: 547  nnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkep 587
           n++e+vs+e++++at+l++ ++  +l++L+++   +l++e+
   Q: 1405 NQREEVSFESITQATGLSQVLIGHALSPLTKGA--ILTQEE 1443
           *******************************86..888775 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

PGSKKKQERG FMQPHDFPSR NAYVDYIQEN LKPGMTVKML EDYDEISTGD EGIFRQSNNG 60
MPPVQVLWSS TGRTYWVHWH MVQIIGSGEQ AEEDIQEKVP TLTDNLKVPP VAQTFQCKPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGGCTCCA AGAAAAAACA GGAGAGAGGG TTTATGCAGC CCCATGATTT CCCTTCCCGA 60
AATGCCTACG TGGATTATAT TCAGGAGAAC CTCAAGCCCG GGATGACAGT CAAGATGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR016150--Casein_kin_II_reg-sub_b-sht
IPR021097--CPH_domain
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR002867--IBR_dom
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50069--CULLIN_2
PS51284--DOC
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8
PF01485--IBR

SMART

SM01337--APC10
SM00884--Cullin_Nedd8
SM00647--IBR

Gene Ontology

GO:0008270--F:zinc ion binding
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001405	Ailuropoda melanoleuca	49.95	0.00e+00	1821.00
IUUC-Apl-003458	Anas platyrhynchos	61.41	0.00e+00	749.00
IUUC-Aca-004815	Anolis carolinensis	58.87	0.00e+00	2311.00
IUUC-Ame-010611	Astyanax mexicanus	54.73	0.00e+00	1922.00
IUUC-Bta-012877	Bos taurus	48.27	0.00e+00	1775.00
IUUC-Cja-019255	Callithrix jacchus	49.61	0.00e+00	1806.00
IUUC-Cfa-020119	Canis familiaris	50.61	0.00e+00	1816.00
IUUC-Cpo-022473	Cavia porcellus	55.29	0.00e+00	1495.00
IUUC-Csa-024157	Chlorocebus sabaeus	49.52	0.00e+00	1801.00
IUUC-Cho-024879	Choloepus hoffmanni	44.21	8.00e-116	412.00
IUUC-Cin-025402	Ciona intestinalis	31.19	0.00e+00	681.00
IUUC-Dno-028904	Dasypus novemcinctus	46.84	0.00e+00	1005.00
IUUC-Dor-030234	Dipodomys ordii	47.23	0.00e+00	857.00
IUUC-Ete-032516	Echinops telfairi	48.69	5.00e-170	593.00
IUUC-Eca-034394	Equus caballus	53.14	0.00e+00	1587.00
IUUC-Eeu-035166	Erinaceus europaeus	55.85	0.00e+00	1307.00
IUUC-Fca-035740	Felis catus	50.23	0.00e+00	1796.00
IUUC-Fal-036672	Ficedula albicollis	50.06	0.00e+00	1241.00
IUUC-Gmo-038795	Gadus morhua	52.69	0.00e+00	926.00
IUUC-Gga-040154	Gallus gallus	58.15	0.00e+00	904.00
IUUC-Gac-041628	Gasterosteus aculeatus	57.13	0.00e+00	1056.00
IUUC-Ggo-045570	Gorilla gorilla	49.18	0.00e+00	1796.00
IUUC-Hsa-046690	Homo sapiens	48.68	0.00e+00	1764.00
IUUC-Itr-048680	Ictidomys tridecemlineatus	50.54	0.00e+00	1826.00
IUUC-Lch-049956	Latimeria chalumnae	62.17	0.00e+00	894.00
IUUC-Loc-052706	Lepisosteus oculatus	58.06	0.00e+00	1987.00
IUUC-Laf-054068	Loxodonta africana	47.76	0.00e+00	833.00
IUUC-Mcc-055727	Macaca mulatta	49.20	0.00e+00	1824.00
IUUC-Meu-056074	Macropus eugenii	56.74	0.00e+00	825.00
IUUC-Mga-059683	Meleagris gallopavo	50.97	5.00e-44	171.00
IUUC-Mmr-060869	Microcebus murinus	49.34	0.00e+00	1778.00
IUUC-Mdo-062902	Monodelphis domestica	49.80	0.00e+00	1035.00
IUUC-Mmu-063991	Mus musculus	49.24	0.00e+00	1782.00
IUUC-Mpu-065974	Mustela putorius furo	49.50	0.00e+00	1788.00
IUUC-Mlu-067036	Myotis lucifugus	48.37	0.00e+00	862.00
IUUC-Nle-069292	Nomascus leucogenys	54.19	0.00e+00	1527.00
IUUC-Opr-071020	Ochotona princeps	48.17	0.00e+00	1080.00
IUUC-Ont-071953	Oreochromis niloticus	52.34	0.00e+00	1955.00
IUUC-Oan-073534	Ornithorhynchus anatinus	53.36	0.00e+00	910.00
IUUC-Ocu-074244	Oryctolagus cuniculus	47.93	0.00e+00	994.00
IUUC-Ola-087072	Oryzias latipes	54.05	0.00e+00	1877.00
IUUC-Oga-088310	Otolemur garnettii	50.63	0.00e+00	1594.00
IUUC-Oar-090174	Ovis aries	48.48	0.00e+00	1734.00
IUUC-Ptr-091410	Pan troglodytes	49.43	0.00e+00	1791.00
IUUC-Pan-091856	Papio anubis	46.44	0.00e+00	914.00
IUUC-Pma-094192	Petromyzon marinus	43.45	0.00e+00	1338.00
IUUC-Pfo-096773	Poecilia formosa	58.20	0.00e+00	1059.00
IUUC-Pab-098635	Pongo abelii	52.82	0.00e+00	1549.00
IUUC-Pca-100539	Procavia capensis	55.46	0.00e+00	790.00
IUUC-Pva-102813	Pteropus vampyrus	49.44	0.00e+00	909.00
IUUC-Rno-106105	Rattus norvegicus	49.47	0.00e+00	1771.00
IUUC-Sha-106896	Sarcophilus harrisii	58.55	0.00e+00	822.00
IUUC-Ssl-108406	Sclerotinia sclerotiorum	37.23	1.00e-07	50.80
IUUC-Sar-113132	Sorex araneus	57.92	0.00e+00	636.00
IUUC-Ssc-116000	Sus scrofa	49.67	0.00e+00	1777.00
IUUC-Tgu-116915	Taeniopygia guttata	57.87	5.00e-128	450.00
IUUC-Tru-118013	Takifugu rubripes	50.59	0.00e+00	1942.00
IUUC-Tsy-118860	Tarsius syrichta	48.57	1.00e-166	580.00
IUUC-Tni-120062	Tetraodon nigroviridis	54.63	0.00e+00	1830.00
IUUC-Tbe-127660	Tupaia belangeri	44.86	2.00e-87	317.00
IUUC-Ttr-128780	Tursiops truncatus	45.60	0.00e+00	967.00
IUUC-Vpa-130086	Vicugna pacos	46.84	0.00e+00	712.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence