iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011918

Ensembl Protein ID

ENSAMXP00000006439.1

UniProt Accession

W5KFS8; W5KFS8_ASTMX

Genbank Protein ID

ENSAMXP00000006439

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01076840

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000006259.1	ENSAMXT00000006439.1	ENSAMXP00000006439.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.30e-62	209.9	520	845

Active Site

Position(s)	Description	Evidence
815	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rle.vefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrl 87
           +++ ++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n  +    ++d ++ np  ++++ +e++G+l+g al+ + +
   Q: 520  QWWeCKFIAEGIIDQGGGFRDSLADMSEELCPSSaecampLPFFTRTSN--QVAGEARDFYVPNPscREFQKYEWIGQLMGAALRGKDF 606
           4555*****************************9888866677765555..55557788888777779********************* PP
   S: 88   ldlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkee 172
           l l l+  ++k+l g+++s+ ed+++vd+ l+k l+ ++++     +++++d++f    v ++ l++ + +eL+pgG ++ V +e++ e
   Q: 607  LVLALPGLVWKQLTGESISWnEDFPAVDSVLVKLLEAMEHM-----DKETFDFKFGqelVYSTPLSDGRLVELIPGGGSVVVRYEDRME 690
           ***************************************77.....555567777644677788************************* PP
   S: 173  YvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefssee 260
           +v+lv + rl+e  keq++a+++G+ +v+p+ +l+l+t++e+e  +cG++ei+ve+lk+  + ++  ++d p+  +  ++l ++fs e+
   Q: 691  FVRLVQKSRLEE-SKEQIAAIQAGLMKVVPQAVLDLLTWQEVEKKVCGDPEITVEALKRLSTQNSLSQQDLPE-TYHTDALmCDFS-ED 776
           ***********9.9*********************************************88776645555555.577777758886.67 PP
   S: 261  rkafLqFvTgssrlPlgGfaelkprlfvirk..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           r++fL+FvTg+srlP+       p  +   k  ++++d lP+s+TC ++L LP+Y+s ++++ekL+yA  ++ +++
   Q: 777  RSRFLRFVTGRSRLPA-------PIYIFPDKqgSETTDALPQSSTCSSTLYLPKYPSAKVCEEKLRYAAYNCVAID 845
           99*************5.......44466666788888*********************************998776 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MSPGQNPHTL LGRIRFLNRC TECFRTGEPL PESLCFVPRE VCYKICKDSS SNSGSSSSSS 60
SAGNSGGKTL VPVWDHPNQP PTRKTARCTI EPKKGTCIRT SGEEYYNSHG LWVKISKEQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCGAT TCGCGGGTGA CTCAGTCGGA TCGGGATTCG TTAGCCGGTG TGACAGATGC 60
TAGCTGTGGG GCTAACGCTT AGTAACTGCT ACCTGGAATG TTCCGCGGTT CCGGGGGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	63.82	0.00e+00	1090.00
IUUC-Apl-003715	Anas platyrhynchos	71.52	0.00e+00	1076.00
IUUC-Aca-004377	Anolis carolinensis	67.63	0.00e+00	1150.00
IUUC-Bta-012736	Bos taurus	64.29	0.00e+00	1101.00
IUUC-Cja-019926	Callithrix jacchus	64.29	0.00e+00	1100.00
IUUC-Cfa-020753	Canis familiaris	75.56	0.00e+00	913.00
IUUC-Cpo-021415	Cavia porcellus	64.06	0.00e+00	1098.00
IUUC-Csa-023096	Chlorocebus sabaeus	64.06	0.00e+00	1096.00
IUUC-Dre-028746	Danio rerio	82.11	0.00e+00	1377.00
IUUC-Dno-029293	Dasypus novemcinctus	76.27	0.00e+00	837.00
IUUC-Dor-031113	Dipodomys ordii	75.21	0.00e+00	956.00
IUUC-Ete-032601	Echinops telfairi	62.84	0.00e+00	957.00
IUUC-Eca-034198	Equus caballus	62.81	0.00e+00	1092.00
IUUC-Eeu-034708	Erinaceus europaeus	75.89	0.00e+00	709.00
IUUC-Fca-035478	Felis catus	64.57	0.00e+00	1095.00
IUUC-Fal-037366	Ficedula albicollis	66.55	0.00e+00	1123.00
IUUC-Gmo-039020	Gadus morhua	80.50	0.00e+00	1059.00
IUUC-Gga-040332	Gallus gallus	68.30	0.00e+00	1169.00
IUUC-Gac-042336	Gasterosteus aculeatus	77.74	0.00e+00	1360.00
IUUC-Ggo-045382	Gorilla gorilla	64.17	0.00e+00	1096.00
IUUC-Hsa-046562	Homo sapiens	64.17	0.00e+00	1096.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	64.17	0.00e+00	1098.00
IUUC-Lch-049606	Latimeria chalumnae	63.40	0.00e+00	774.00
IUUC-Loc-052448	Lepisosteus oculatus	67.25	0.00e+00	1120.00
IUUC-Laf-054507	Loxodonta africana	64.11	0.00e+00	1118.00
IUUC-Mcc-055690	Macaca mulatta	63.94	0.00e+00	1094.00
IUUC-Meu-055970	Macropus eugenii	64.93	0.00e+00	1078.00
IUUC-Mga-059654	Meleagris gallopavo	71.23	0.00e+00	1053.00
IUUC-Mmr-061069	Microcebus murinus	64.52	0.00e+00	1102.00
IUUC-Mdo-062547	Monodelphis domestica	77.07	0.00e+00	655.00
IUUC-Mmu-063096	Mus musculus	64.40	0.00e+00	1100.00
IUUC-Mpu-065846	Mustela putorius furo	63.82	0.00e+00	1097.00
IUUC-Mlu-067992	Myotis lucifugus	68.05	0.00e+00	1066.00
IUUC-Nle-069565	Nomascus leucogenys	62.55	0.00e+00	1001.00
IUUC-Opr-070853	Ochotona princeps	63.44	0.00e+00	757.00
IUUC-Ont-071628	Oreochromis niloticus	78.57	0.00e+00	1321.00
IUUC-Ocu-074094	Oryctolagus cuniculus	64.52	0.00e+00	1102.00
IUUC-Ola-087384	Oryzias latipes	78.32	0.00e+00	1359.00
IUUC-Oga-088224	Otolemur garnettii	64.17	0.00e+00	1102.00
IUUC-Oar-090043	Ovis aries	62.88	0.00e+00	1037.00
IUUC-Ptr-090852	Pan troglodytes	64.06	0.00e+00	1090.00
IUUC-Pan-092787	Papio anubis	63.94	0.00e+00	1095.00
IUUC-Psi-092986	Pelodiscus sinensis	61.85	0.00e+00	789.00
IUUC-Pma-094416	Petromyzon marinus	37.79	5.00e-161	561.00
IUUC-Pfo-096720	Poecilia formosa	78.04	0.00e+00	1373.00
IUUC-Pab-098325	Pongo abelii	61.56	0.00e+00	816.00
IUUC-Pca-100885	Procavia capensis	57.58	0.00e+00	803.00
IUUC-Pva-102829	Pteropus vampyrus	52.62	0.00e+00	627.00
IUUC-Rno-104882	Rattus norvegicus	64.29	0.00e+00	1103.00
IUUC-Sha-106811	Sarcophilus harrisii	78.77	3.00e-98	352.00
IUUC-Sar-113020	Sorex araneus	70.00	1.00e-172	600.00
IUUC-Ssc-115436	Sus scrofa	56.78	9.00e-85	306.00
IUUC-Tgu-117042	Taeniopygia guttata	68.38	0.00e+00	1170.00
IUUC-Tru-118419	Takifugu rubripes	75.35	0.00e+00	1264.00
IUUC-Tsy-118829	Tarsius syrichta	64.14	0.00e+00	646.00
IUUC-Tni-120410	Tetraodon nigroviridis	64.75	0.00e+00	1019.00
IUUC-Tbe-128113	Tupaia belangeri	76.18	2.00e-173	602.00
IUUC-Ttr-128167	Tursiops truncatus	61.57	0.00e+00	1033.00
IUUC-Xtr-132910	Xenopus tropicalis	59.79	0.00e+00	948.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence