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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063655
UUCD1 version UUC-MuM-00407
Ensembl Protein ID ENSMUSP00000032107.7
UniProt Accession Q3UQV5; Q3TJB2; Q5M7B2; Q8CH97; KBTB8_MOUSE
Genbank Protein ID BAE24933.1; BAE39583.1; AAH88734.1; BAC41484.1
Protein Name Kelch repeat and BTB domain-containing protein 8
Genbank Nucleotide ID AK142080; AK167507; BC088734; AB093302
Gene Name Kbtbd8; Kiaa1842
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030031.14 ENSMUST00000122938.7 ENSMUSP00000145009.1
ENSMUSG00000030031.14 ENSMUST00000032107.9 ENSMUSP00000032107.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.60e-17 63.6 49 117
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +D++++v+ g+ f++h+ vLaa S++F+++f+++l es+ +++v i +v++e++  +l++ Yt+++ ++e
   Q: 49   TDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTEST-QKEVRIIGVEAESMDLVLNYAYTSRVILTE 117
           6999***9******************************9.*************************98765 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Protein Sequence
(Fasta)
MAASADLSKS SPTPNGIPSS DTANDTMDPF HACSILKQLK TMYDEGQLTD IVVEVDHGKT 60
FSCHRNVLAA ISPYFRSMFT SGLTESTQKE VRIIGVEAES MDLVLNYAYT SRVILTEANV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063655|E3,BTB_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGTGGCCAT GTAACCAGAC CCAGTTGATC TGTGAAAAGC GGGGCATGTG GCTAAGGGGA 60
TGCAATTTCA AGTGGGCGTT ACAGGTGACT CATCAGAGAC CTATCGATGG TGTGTGTGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063655|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0333--Golgi apparatus
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0810--Translation regulation
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR028764--KBTBD8
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0005819--C:spindle
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG mmu:243574
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001555 Ailuropoda melanoleuca 96.51 0.00e+00 1202.00
IUUC-Apl-004152 Anas platyrhynchos 87.90 0.00e+00 1080.00
IUUC-Aca-005367 Anolis carolinensis 87.65 0.00e+00 1073.00
IUUC-Bta-012910 Bos taurus 96.01 0.00e+00 1196.00
IUUC-Bra-017560 Brassica rapa 29.90 2.00e-14 74.30
IUUC-Cja-019722 Callithrix jacchus 97.24 0.00e+00 757.00
IUUC-Cfa-020071 Canis familiaris 95.17 0.00e+00 1189.00
IUUC-Cpo-021642 Cavia porcellus 92.69 0.00e+00 1133.00
IUUC-Csa-023578 Chlorocebus sabaeus 97.39 0.00e+00 1160.00
IUUC-Cho-024601 Choloepus hoffmanni 96.81 0.00e+00 782.00
IUUC-Dre-028688 Danio rerio 72.92 0.00e+00 957.00
IUUC-Dno-029176 Dasypus novemcinctus 93.42 0.00e+00 1143.00
IUUC-Dor-030189 Dipodomys ordii 90.43 0.00e+00 1055.00
IUUC-Ete-032523 Echinops telfairi 91.71 0.00e+00 787.00
IUUC-Eca-034064 Equus caballus 95.98 0.00e+00 986.00
IUUC-Fca-035368 Felis catus 95.84 0.00e+00 1195.00
IUUC-Fal-037559 Ficedula albicollis 87.23 0.00e+00 1100.00
IUUC-Gmo-039491 Gadus morhua 72.21 0.00e+00 904.00
IUUC-Gga-041061 Gallus gallus 88.03 0.00e+00 1087.00
IUUC-Gac-041498 Gasterosteus aculeatus 72.34 0.00e+00 912.00
IUUC-Ggo-045566 Gorilla gorilla 97.34 0.00e+00 1208.00
IUUC-Hsa-045922 Homo sapiens 97.50 0.00e+00 1211.00
IUUC-Itr-047903 Ictidomys tridecemlineatus 91.68 0.00e+00 1149.00
IUUC-Lch-049733 Latimeria chalumnae 77.54 0.00e+00 971.00
IUUC-Loc-052890 Lepisosteus oculatus 73.26 0.00e+00 959.00
IUUC-Laf-053776 Loxodonta africana 95.47 2.00e-147 516.00
IUUC-Mmr-060999 Microcebus murinus 90.20 0.00e+00 1099.00
IUUC-Mdo-063061 Monodelphis domestica 89.24 0.00e+00 1023.00
IUUC-Mpu-066789 Mustela putorius furo 96.17 0.00e+00 1198.00
IUUC-Mlu-067917 Myotis lucifugus 94.59 0.00e+00 1125.00
IUUC-Nle-069449 Nomascus leucogenys 97.50 0.00e+00 1213.00
IUUC-Ont-071291 Oreochromis niloticus 73.55 0.00e+00 950.00
IUUC-Oan-073260 Ornithorhynchus anatinus 87.04 0.00e+00 1080.00
IUUC-Ocu-073840 Oryctolagus cuniculus 95.01 0.00e+00 1176.00
IUUC-Ola-086878 Oryzias latipes 72.61 0.00e+00 942.00
IUUC-Oga-087953 Otolemur garnettii 96.84 0.00e+00 1203.00
IUUC-Oar-089418 Ovis aries 95.84 0.00e+00 1194.00
IUUC-Ptr-090765 Pan troglodytes 97.57 0.00e+00 1157.00
IUUC-Pan-091713 Papio anubis 96.67 0.00e+00 1206.00
IUUC-Psi-094050 Pelodiscus sinensis 88.44 0.00e+00 1092.00
IUUC-Pma-094653 Petromyzon marinus 50.78 7.00e-172 597.00
IUUC-Pfo-096352 Poecilia formosa 73.43 0.00e+00 947.00
IUUC-Pab-098712 Pongo abelii 98.80 0.00e+00 709.00
IUUC-Pca-100707 Procavia capensis 93.87 3.00e-114 405.00
IUUC-Pva-102231 Pteropus vampyrus 97.48 4.00e-170 591.00
IUUC-Rno-105214 Rattus norvegicus 98.84 0.00e+00 1225.00
IUUC-Sha-106490 Sarcophilus harrisii 88.41 0.00e+00 1028.00
IUUC-Sar-113362 Sorex araneus 95.30 0.00e+00 1139.00
IUUC-Tgu-117035 Taeniopygia guttata 87.76 0.00e+00 1098.00
IUUC-Tru-118510 Takifugu rubripes 71.92 0.00e+00 928.00
IUUC-Tsy-119204 Tarsius syrichta 97.57 0.00e+00 1162.00
IUUC-Tni-120173 Tetraodon nigroviridis 72.25 0.00e+00 935.00
IUUC-Ttr-128377 Tursiops truncatus 91.13 0.00e+00 1065.00
IUUC-Vpa-130133 Vicugna pacos 96.08 1.00e-88 320.00
Created Date 25-Jun-2017

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