iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023270

Ensembl Protein ID

ENSCSAP00000016961.1

UniProt Accession

A0A0D9S7X2; A0A0D9S7X2_CHLSB

Genbank Protein ID

ENSCSAP00000016961

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AQIB01142551

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000001052.1	ENSCSAT00000017481.1	ENSCSAP00000016961.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-19	69.0	62	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l++ye+++d++L ++kG++++++   eq+++W+k+++ ++g++G++P nFv+k++
   Q: 62   QDNLVIALHSYEPSHDGDLGFEKGEQLRIL---EQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
           6899**************************...**************************987 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGCTACG ACGGTGAAGG GAGCTGAGAC TGTCCAGGCA GCCAACTTAG GCCAGGAGGA 60
CCATGTGAAT GGGACCAGAG GGCTCCCGGG CTGGGCAGGT AAGGAGCGCT GGTACTGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	75.27	0.00e+00	794.00
IUUC-Bta-013264	Bos taurus	77.61	0.00e+00	799.00
IUUC-Cfa-021161	Canis familiaris	74.77	0.00e+00	792.00
IUUC-Cpo-022492	Cavia porcellus	76.64	0.00e+00	783.00
IUUC-Dno-029365	Dasypus novemcinctus	77.78	0.00e+00	789.00
IUUC-Dor-030892	Dipodomys ordii	73.37	0.00e+00	718.00
IUUC-Eca-033325	Equus caballus	76.30	0.00e+00	771.00
IUUC-Eeu-035004	Erinaceus europaeus	77.20	0.00e+00	654.00
IUUC-Fca-035908	Felis catus	78.38	0.00e+00	804.00
IUUC-Ggo-045238	Gorilla gorilla	76.19	0.00e+00	812.00
IUUC-Hsa-047039	Homo sapiens	80.31	0.00e+00	825.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	78.76	0.00e+00	809.00
IUUC-Laf-054499	Loxodonta africana	73.99	0.00e+00	788.00
IUUC-Mcc-054872	Macaca mulatta	63.02	0.00e+00	662.00
IUUC-Meu-056879	Macropus eugenii	75.24	0.00e+00	777.00
IUUC-Mmr-060740	Microcebus murinus	77.99	0.00e+00	800.00
IUUC-Mdo-062192	Monodelphis domestica	74.52	0.00e+00	766.00
IUUC-Mmu-064241	Mus musculus	77.01	0.00e+00	796.00
IUUC-Mpu-066595	Mustela putorius furo	77.99	0.00e+00	800.00
IUUC-Mlu-067069	Myotis lucifugus	76.49	0.00e+00	784.00
IUUC-Opr-070472	Ochotona princeps	74.68	0.00e+00	791.00
IUUC-Oan-073505	Ornithorhynchus anatinus	59.08	6.00e-160	557.00
IUUC-Ocu-074221	Oryctolagus cuniculus	77.84	0.00e+00	795.00
IUUC-Oga-088225	Otolemur garnettii	77.80	0.00e+00	798.00
IUUC-Oar-090244	Ovis aries	68.13	0.00e+00	735.00
IUUC-Pan-091804	Papio anubis	80.69	0.00e+00	831.00
IUUC-Psi-093252	Pelodiscus sinensis	60.62	1.00e-176	612.00
IUUC-Pab-098168	Pongo abelii	78.63	0.00e+00	767.00
IUUC-Pca-100547	Procavia capensis	96.88	0.00e+00	645.00
IUUC-Rno-105542	Rattus norvegicus	76.82	0.00e+00	795.00
IUUC-Sha-107524	Sarcophilus harrisii	73.94	0.00e+00	763.00
IUUC-Sja-107776	Schizosaccharomyces japonicus	46.15	4.00e-07	47.00
IUUC-Sar-113235	Sorex araneus	71.34	0.00e+00	650.00
IUUC-Ssc-115624	Sus scrofa	77.41	0.00e+00	795.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence