iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-068176

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02024548

Gene Name

BRCA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000004135.2	ENSMLUT00000004141.2	ENSMLUP00000003770.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.50e-08	32.8	22	63

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 22   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQKKGPSQCPLCK 63
           ********99.**************9666...68899********7 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

LCADRVEEVQ NVLNAMQKIL ECPICLELIK EPVSTKCDHI FCKFCMLKLL NQKKGPSQCP 60
LCKNDITKRS LQESTRFSQL VEELLKIIHA FELDTGLPFT NSYSFSKKEN NSPEHLNEEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTATGTGCGG ATCGAGTTGA AGAAGTACAA AATGTCCTTA ATGCTATGCA GAAAATCTTA 60
GAGTGTCCAA TCTGGTAAGT CAACAGAATT TATTAACTTG AGATTTTTCC TTATATGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	73.63	0.00e+00	2611.00
IUUC-Apl-003252	Anas platyrhynchos	34.56	5.00e-117	416.00
IUUC-Aca-004526	Anolis carolinensis	48.90	2.00e-73	270.00
IUUC-Ame-011720	Astyanax mexicanus	46.05	3.00e-53	204.00
IUUC-Bgr-011969	Blumeria graminis	38.89	2.00e-08	53.90
IUUC-Bta-013433	Bos taurus	70.09	0.00e+00	2415.00
IUUC-Cel-018208	Caenorhabditis elegans	32.61	6.00e-11	62.40
IUUC-Cja-019149	Callithrix jacchus	70.46	0.00e+00	2403.00
IUUC-Cfa-020322	Canis familiaris	72.19	0.00e+00	2492.00
IUUC-Cpo-021583	Cavia porcellus	44.70	0.00e+00	1234.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	29.41	9.00e-09	54.70
IUUC-Csa-024227	Chlorocebus sabaeus	71.90	7.00e-140	490.00
IUUC-Cho-024530	Choloepus hoffmanni	67.99	0.00e+00	1172.00
IUUC-Cin-025364	Ciona intestinalis	44.16	4.00e-15	75.50
IUUC-Csv-026245	Ciona savignyi	39.74	2.00e-13	69.30
IUUC-Dno-029247	Dasypus novemcinctus	68.95	0.00e+00	1946.00
IUUC-Dme-032032	Drosophila melanogaster	54.35	7.00e-11	58.50
IUUC-Ete-032472	Echinops telfairi	53.84	0.00e+00	1593.00
IUUC-Eca-033446	Equus caballus	77.06	0.00e+00	2741.00
IUUC-Eeu-034858	Erinaceus europaeus	61.39	0.00e+00	977.00
IUUC-Fca-035991	Felis catus	74.16	0.00e+00	2649.00
IUUC-Fal-036803	Ficedula albicollis	62.09	2.00e-78	288.00
IUUC-Gmo-038782	Gadus morhua	44.56	7.00e-45	176.00
IUUC-Ggr-039833	Gaeumannomyces graminis	36.73	1.00e-07	51.20
IUUC-Gga-040969	Gallus gallus	60.00	3.00e-78	288.00
IUUC-Gac-042296	Gasterosteus aculeatus	43.40	1.00e-50	195.00
IUUC-Ggo-044740	Gorilla gorilla	69.76	0.00e+00	2327.00
IUUC-Hsa-046086	Homo sapiens	72.35	0.00e+00	2402.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	69.16	0.00e+00	2425.00
IUUC-Lch-049789	Latimeria chalumnae	35.30	5.00e-87	317.00
IUUC-Loc-051952	Lepisosteus oculatus	52.47	2.00e-68	254.00
IUUC-Laf-053648	Loxodonta africana	71.41	0.00e+00	2371.00
IUUC-Mcc-055210	Macaca mulatta	71.04	0.00e+00	2439.00
IUUC-Meu-056342	Macropus eugenii	39.06	8.00e-130	459.00
IUUC-Mor-057034	Magnaporthe oryzae	38.78	3.00e-08	53.10
IUUC-Mpo-057316	Magnaporthe poae	39.13	7.00e-08	52.00
IUUC-Mga-060163	Meleagris gallopavo	54.85	8.00e-81	296.00
IUUC-Mmr-061402	Microcebus murinus	67.85	0.00e+00	770.00
IUUC-Mdo-062209	Monodelphis domestica	44.13	0.00e+00	1229.00
IUUC-Mmu-064003	Mus musculus	53.79	0.00e+00	1644.00
IUUC-Mpu-065825	Mustela putorius furo	74.41	0.00e+00	754.00
IUUC-Nle-069178	Nomascus leucogenys	71.98	0.00e+00	2435.00
IUUC-Opr-070574	Ochotona princeps	57.16	0.00e+00	1779.00
IUUC-Ont-072380	Oreochromis niloticus	47.85	5.00e-57	217.00
IUUC-Oan-073243	Ornithorhynchus anatinus	77.50	2.00e-33	134.00
IUUC-Ocu-074424	Oryctolagus cuniculus	66.19	0.00e+00	2222.00
IUUC-Ola-086863	Oryzias latipes	45.74	1.00e-53	205.00
IUUC-Oar-089938	Ovis aries	69.93	0.00e+00	2454.00
IUUC-Ptr-090960	Pan troglodytes	72.51	0.00e+00	2433.00
IUUC-Pan-092609	Papio anubis	69.91	0.00e+00	2101.00
IUUC-Psi-093889	Pelodiscus sinensis	26.45	2.00e-38	154.00
IUUC-Pfo-096328	Poecilia formosa	44.75	3.00e-58	221.00
IUUC-Pab-097982	Pongo abelii	72.25	0.00e+00	2447.00
IUUC-Pca-100698	Procavia capensis	64.27	0.00e+00	658.00
IUUC-Pva-102631	Pteropus vampyrus	79.36	0.00e+00	1250.00
IUUC-Rno-105879	Rattus norvegicus	53.76	0.00e+00	1627.00
IUUC-Sha-106701	Sarcophilus harrisii	38.45	0.00e+00	652.00
IUUC-Spo-108335	Schizosaccharomyces pombe	32.32	5.00e-10	58.90
IUUC-Sar-113047	Sorex araneus	62.68	0.00e+00	1440.00
IUUC-Ssc-115846	Sus scrofa	72.68	0.00e+00	2572.00
IUUC-Tgu-116785	Taeniopygia guttata	30.35	8.00e-84	306.00
IUUC-Tru-117895	Takifugu rubripes	41.63	6.00e-52	199.00
IUUC-Tsy-118885	Tarsius syrichta	55.10	0.00e+00	628.00
IUUC-Tni-119654	Tetraodon nigroviridis	42.58	1.00e-48	189.00
IUUC-Tbe-127421	Tupaia belangeri	59.39	7.00e-141	495.00
IUUC-Ttr-128685	Tursiops truncatus	74.24	0.00e+00	2464.00
IUUC-Vda-129783	Verticillium dahliae	34.33	6.00e-09	55.50
IUUC-Vpa-130216	Vicugna pacos	69.83	0.00e+00	836.00
IUUC-Xtr-132398	Xenopus tropicalis	35.31	7.00e-59	223.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence