iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000168010.10	ENST00000321297.9	ENSP00000326340.5
ENSG00000168010.10	ENST00000534905.5	ENSP00000441189.1
ENSG00000168010.10	ENST00000435507.6	ENSP00000400705.2
ENSG00000168010.10	ENST00000540567.1	ENSP00000443569.1
ENSG00000168010.10	ENST00000541999.5	ENSP00000442931.1
ENSG00000168010.10	ENST00000535830.5	ENSP00000438474.1
ENSG00000168010.10	ENST00000538973.5	ENSP00000441989.1
ENSG00000168010.10	ENST00000541367.5	ENSP00000437412.1
ENSG00000168010.10	ENST00000540222.5	ENSP00000441747.1
ENSG00000168010.10	ENST00000537837.5	ENSP00000437932.1
ENSG00000168010.10	ENST00000541554.1	ENSP00000441132.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-28	98.2	335	365
UBD/Beta-Prp	6.50e-46	158.5	333	619

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++v++++f ++  ll++G+ D  i++W++
   Q: 335  HLSEVNAVRFgPNsSLLATGGADRLIHLWNV 365
           99*********7779***************7 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
           ++h s +++v f p++sllatg++d+ i +w+v    l   ++l+g  + +t+v+f+p+g   + +   +++++w +   +   tl+gh+d+
   Q: 333  DAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLeaNQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDK 424
           6899999****************************99988899*****************888888889*********************** PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
           v++ +f  +++  v+Gs+drt++ wdl   +c++ t ++ +    c  v + + +++sG++D+++r+Wd++   + +      +++v+sls+
   Q: 425  VTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSR-TINVLS---YCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIP--VQGRVTSLSL 510
           *********************************9.666655...4555555556*************************5..589******* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgec.....vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsf 275
           ++++ +l+s+s+d+t+k+ dl+ +++      + +++ +d++k   fsp+  + + gs+Dg ++iWd+++g+l + lq+++   +   ++++
   Q: 511  SHDQLHLLSCSRDNTLKVIDLRVSNIrqvfrADGFKCGSDWTK-AVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCY 601
           **********************888833334444555556666.8899*********************************777777778** PP
   S: 276  gdnvlvlgsedskvniwk 293
           +++++v++++  kv +w+
   Q: 602  SGSHMVSVDQGRKVVLWQ 619
           **************9995 PP

Organism

Homo sapiens

Functional Description
(View)

May play a role in autophagy.

Protein Sequence
(Fasta)

MAGPGVPGAP AARWKRHIVR QLRLRDRTQK ALFLELVPAY NHLLEKAELL DKFSKKLQPE 60
PNSVTPTTHQ GPWEESELDS DQVPSLVALR VKWQEEEEGL RLVCGEMAYQ VVEKGAALGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAAAGCCCT CTTGGGACAA GCCGGGGATT CCCCGCCGCC GCCCGCCCCC TGGCGTCACG 60
GAGTCCCCGC GAGGCCCCGC CCCGGCCTGG CGCCGTCCTG GGCGGGAGGA ACGCGCCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR013923--Autophagy-rel_prot_16
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08614--ATG16
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0005654--C:nucleoplasm
GO:0000045--P:autophagosome assembly
GO:0039689--P:negative stranded viral RNA replication
GO:0015031--P:protein transport

KEGG

hsa:89849

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001470	Ailuropoda melanoleuca	68.67	0.00e+00	754.00
IUUC-Atr-003073	Amborella trichopoda	31.76	2.00e-27	117.00
IUUC-Ame-011152	Astyanax mexicanus	42.04	5.00e-117	414.00
IUUC-Bta-013118	Bos taurus	85.78	0.00e+00	950.00
IUUC-Cja-020002	Callithrix jacchus	90.97	0.00e+00	1013.00
IUUC-Cfa-020878	Canis familiaris	83.20	0.00e+00	931.00
IUUC-Cpo-022476	Cavia porcellus	84.09	0.00e+00	912.00
IUUC-Csa-024134	Chlorocebus sabaeus	94.85	0.00e+00	1058.00
IUUC-Cho-024853	Choloepus hoffmanni	71.21	5.00e-179	620.00
IUUC-Dre-027949	Danio rerio	42.04	2.00e-128	452.00
IUUC-Dno-029683	Dasypus novemcinctus	85.63	0.00e+00	782.00
IUUC-Dor-030897	Dipodomys ordii	79.00	0.00e+00	942.00
IUUC-Ete-032957	Echinops telfairi	93.23	1.00e-131	463.00
IUUC-Eca-033303	Equus caballus	90.43	1.00e-163	568.00
IUUC-Eeu-035336	Erinaceus europaeus	73.76	4.00e-153	535.00
IUUC-Fca-036232	Felis catus	85.81	0.00e+00	1010.00
IUUC-Gmo-038880	Gadus morhua	50.35	3.00e-71	262.00
IUUC-Gac-042500	Gasterosteus aculeatus	41.14	1.00e-95	343.00
IUUC-Ggo-045130	Gorilla gorilla	99.50	0.00e+00	756.00
IUUC-Itr-048780	Ictidomys tridecemlineatus	87.07	0.00e+00	986.00
IUUC-Lch-050669	Latimeria chalumnae	54.22	3.00e-95	341.00
IUUC-Loc-052789	Lepisosteus oculatus	43.16	1.00e-115	410.00
IUUC-Laf-053699	Loxodonta africana	86.72	0.00e+00	958.00
IUUC-Mcc-055657	Macaca mulatta	90.31	0.00e+00	944.00
IUUC-Meu-056639	Macropus eugenii	49.61	1.00e-108	387.00
IUUC-Mmr-061314	Microcebus murinus	81.35	0.00e+00	864.00
IUUC-Mdo-061841	Monodelphis domestica	64.50	0.00e+00	697.00
IUUC-Mmu-064065	Mus musculus	83.09	0.00e+00	949.00
IUUC-Mpu-066742	Mustela putorius furo	83.71	0.00e+00	910.00
IUUC-Mlu-067019	Myotis lucifugus	88.59	0.00e+00	678.00
IUUC-Nle-069037	Nomascus leucogenys	98.52	0.00e+00	1099.00
IUUC-Opr-071039	Ochotona princeps	82.71	0.00e+00	912.00
IUUC-Oan-073431	Ornithorhynchus anatinus	72.22	2.00e-139	488.00
IUUC-Ocu-074772	Oryctolagus cuniculus	85.27	0.00e+00	847.00
IUUC-Ola-086964	Oryzias latipes	52.61	2.00e-83	302.00
IUUC-Oga-088188	Otolemur garnettii	87.40	0.00e+00	909.00
IUUC-Oar-090231	Ovis aries	79.58	0.00e+00	926.00
IUUC-Ptr-091434	Pan troglodytes	96.39	0.00e+00	1000.00
IUUC-Pan-091868	Papio anubis	95.80	0.00e+00	1036.00
IUUC-Psi-093652	Pelodiscus sinensis	64.12	1.00e-165	576.00
IUUC-Pfo-096960	Poecilia formosa	43.42	3.00e-104	372.00
IUUC-Pab-097776	Pongo abelii	97.69	0.00e+00	1001.00
IUUC-Pca-100220	Procavia capensis	66.83	0.00e+00	637.00
IUUC-Pva-103135	Pteropus vampyrus	87.62	0.00e+00	883.00
IUUC-Rno-105529	Rattus norvegicus	81.57	0.00e+00	976.00
IUUC-Sha-107062	Sarcophilus harrisii	64.49	0.00e+00	728.00
IUUC-Sar-113109	Sorex araneus	67.24	5.00e-133	468.00
IUUC-Ssc-115271	Sus scrofa	87.12	0.00e+00	934.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence