iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117364

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ABQF01036685

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000004503.1	ENSTGUT00000004718.1	ENSTGUP00000004669.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.90e-109	364.1	140	678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 140  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPSSLSHGIKLVNPMFRGYA 223
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+         +++++e+           +                                        
   Q: 224  QQDTQEFLRCLMDQLHEELKEpvvaetrdLDTSDQED-----------Kregdrspsedeflscdsssdrgegegqsrtsgsmgsssla 301
           *******************885544433322222333...........233355566677***************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 302  etelliqdeagrgisekermkdrkfscghrrsnseqvdedadvdttmmpvdgraspemlpapcpaspcrtpepdndayvrcssrpcspv 390
           ***************************************************************************************** PP
   S: 130  ..................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
                                              ++kk+ +++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k
   Q: 391  hhemhsklssspprssparlgpsyilkkaqmqasGKKKKELRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAK 479
           ********************************9999999999*******************************************9988 PP
   S: 185  e.................................................slqdcLesftkeeele..genkyycekckkkqeaekklk 222
           +                                                 +l+dcL++f++++el+  g+n+y+ce+ckk+++ +k +k
   Q: 480  LhsaiyqnvpaktgacgdnyasqgwiafimeyirrfvvscipswfwgpvvTLEDCLAAFFAADELKatGDNMYSCERCKKLRNGVKYCK 568
           8***************************************************************964489******************* PP
   S: 223  lkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllf 309
           + +lPe+L++hLkRf  ++e + + kin++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++f
   Q: 569  VLRLPEILCIHLKRF--RHEVMYSFKINSHVSFPLEgLDLRPFLAKECVSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEF 653
           ***************..9999*************************99888..9**************************78999**** PP
   S: 310  dDskVtevkeeevleetgstaYvlfYkr 337
           dD++Vtev+e+ v++   ++aYvlfY++
   Q: 654  DDQYVTEVHETVVQN---AEAYVLFYRK 678
           ***************...********98 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

DICPHLDSIG EVTRDDLLLK SKGTCQSCGA AGPNLWACLQ IGCPYVGCGE SFADHSTLHA 60
QAKKHNLTVN LTTFRVWCYA CEKEVFLEQR LAAQPPSPPS KFPEPDSPLP AHPLKAVPIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACATCTGTC CTCACTTGGA TTCCATAGGA GAGGTGACCA GGGATGATCT GCTGCTCAAA 60
TCCAAGGTAC AGGGTTGTGG CTCTCAGTTC TTTCCCTTTT AGCTGTTGTG CATGGATTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	84.17	0.00e+00	1523.00
IUUC-Apl-003351	Anas platyrhynchos	97.36	0.00e+00	1779.00
IUUC-Aca-005077	Anolis carolinensis	79.76	0.00e+00	1147.00
IUUC-Ame-011777	Astyanax mexicanus	75.46	0.00e+00	1341.00
IUUC-Bta-013063	Bos taurus	85.36	0.00e+00	1530.00
IUUC-Cja-019868	Callithrix jacchus	85.61	0.00e+00	1558.00
IUUC-Cfa-020761	Canis familiaris	84.83	0.00e+00	1541.00
IUUC-Cpo-022267	Cavia porcellus	80.81	0.00e+00	1452.00
IUUC-Csa-024251	Chlorocebus sabaeus	86.67	0.00e+00	1573.00
IUUC-Cho-024483	Choloepus hoffmanni	94.34	5.00e-122	431.00
IUUC-Dre-028061	Danio rerio	75.38	0.00e+00	1216.00
IUUC-Dno-029423	Dasypus novemcinctus	86.34	0.00e+00	1558.00
IUUC-Dor-030877	Dipodomys ordii	85.05	0.00e+00	1006.00
IUUC-Dme-031837	Drosophila melanogaster	48.94	1.00e-137	483.00
IUUC-Ete-032802	Echinops telfairi	74.64	1.00e-130	460.00
IUUC-Eca-034283	Equus caballus	84.72	0.00e+00	1540.00
IUUC-Eeu-034620	Erinaceus europaeus	82.63	0.00e+00	1074.00
IUUC-Fca-036357	Felis catus	85.26	0.00e+00	1525.00
IUUC-Fal-037411	Ficedula albicollis	99.12	0.00e+00	1783.00
IUUC-Gga-041101	Gallus gallus	95.15	0.00e+00	1732.00
IUUC-Gac-041315	Gasterosteus aculeatus	74.33	0.00e+00	1333.00
IUUC-Ggo-045600	Gorilla gorilla	86.71	0.00e+00	1539.00
IUUC-Hsa-045825	Homo sapiens	86.56	0.00e+00	1545.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	73.58	0.00e+00	1276.00
IUUC-Lch-050002	Latimeria chalumnae	78.10	0.00e+00	1370.00
IUUC-Loc-052574	Lepisosteus oculatus	78.63	0.00e+00	1419.00
IUUC-Laf-054428	Loxodonta africana	86.04	0.00e+00	1546.00
IUUC-Mcc-055736	Macaca mulatta	86.45	0.00e+00	1571.00
IUUC-Mga-059781	Meleagris gallopavo	94.75	0.00e+00	1739.00
IUUC-Mdo-063048	Monodelphis domestica	90.21	0.00e+00	1567.00
IUUC-Mmu-064079	Mus musculus	82.77	0.00e+00	1506.00
IUUC-Mpu-066616	Mustela putorius furo	84.86	0.00e+00	1581.00
IUUC-Mlu-067294	Myotis lucifugus	84.61	0.00e+00	1482.00
IUUC-Nle-070015	Nomascus leucogenys	86.67	0.00e+00	1536.00
IUUC-Opr-070328	Ochotona princeps	85.46	0.00e+00	1543.00
IUUC-Ont-071464	Oreochromis niloticus	76.66	0.00e+00	1323.00
IUUC-Oan-073259	Ornithorhynchus anatinus	82.26	0.00e+00	1374.00
IUUC-Ocu-074630	Oryctolagus cuniculus	82.44	0.00e+00	1476.00
IUUC-Ola-087240	Oryzias latipes	75.65	0.00e+00	1300.00
IUUC-Oga-088761	Otolemur garnettii	84.79	0.00e+00	1549.00
IUUC-Oar-089490	Ovis aries	81.63	0.00e+00	1396.00
IUUC-Ptr-091662	Pan troglodytes	86.45	0.00e+00	1542.00
IUUC-Pan-092199	Papio anubis	87.10	0.00e+00	1573.00
IUUC-Psi-093726	Pelodiscus sinensis	93.39	0.00e+00	1700.00
IUUC-Pma-094389	Petromyzon marinus	65.26	2.00e-100	358.00
IUUC-Pab-098632	Pongo abelii	86.34	0.00e+00	1536.00
IUUC-Pca-100614	Procavia capensis	78.94	0.00e+00	1196.00
IUUC-Pva-102922	Pteropus vampyrus	81.96	0.00e+00	867.00
IUUC-Rno-105215	Rattus norvegicus	82.75	0.00e+00	1509.00
IUUC-Sce-106176	Saccharomyces cerevisiae	29.73	5.00e-25	109.00
IUUC-Sha-106601	Sarcophilus harrisii	87.77	0.00e+00	1540.00
IUUC-Ssc-115533	Sus scrofa	84.29	0.00e+00	1521.00
IUUC-Tru-117770	Takifugu rubripes	74.68	0.00e+00	1308.00
IUUC-Tni-120001	Tetraodon nigroviridis	74.17	0.00e+00	1281.00
IUUC-Ttr-128732	Tursiops truncatus	85.48	0.00e+00	1543.00
IUUC-Xtr-132157	Xenopus tropicalis	77.80	0.00e+00	1381.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence