iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065887

Ensembl Protein ID

ENSMPUP00000000123.1

UniProt Accession

M3XM23; M3XM23_MUSPF

Genbank Protein ID

ENSMPUP00000000123

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AEYP01014335

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000000127.1	ENSMPUT00000000127.1	ENSMPUP00000000123.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	92.80	0.00e+00	1763.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
802	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Mustela putorius furo

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MSSQSRPDGL SGRDQPVELL NPTRVNHMPS TVDMASALPL QVAPPAVPMD LRLDHQFALP 60
VAEPTLREQQ LQQELLALKQ KQQLQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQELLA 120

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Nucleotide Sequence
(Fasta)

GCCCCACGCA GTATAGATGT GTGGGCGAGG GGCCTGGCCG CGTGTGGTGG GGGTGGCCTG 60
GGGCTCCCGG TTGGTGGTGC TGGTGCCAAG GCTGAGAACC GCTGCTCTGT GACGTGTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	95.80	0.00e+00	1829.00
IUUC-Apl-003250	Anas platyrhynchos	87.45	0.00e+00	1603.00
IUUC-Aca-004668	Anolis carolinensis	83.12	0.00e+00	1655.00
IUUC-Bta-013215	Bos taurus	94.47	0.00e+00	1798.00
IUUC-Cja-019816	Callithrix jacchus	92.33	0.00e+00	1796.00
IUUC-Cfa-020861	Canis familiaris	95.44	0.00e+00	1818.00
IUUC-Cpo-021562	Cavia porcellus	91.57	0.00e+00	1778.00
IUUC-Csa-023612	Chlorocebus sabaeus	91.99	0.00e+00	1766.00
IUUC-Csv-026359	Ciona savignyi	54.73	1.00e-94	339.00
IUUC-Dre-028284	Danio rerio	86.41	0.00e+00	861.00
IUUC-Dno-029951	Dasypus novemcinctus	90.12	0.00e+00	1612.00
IUUC-Dor-030362	Dipodomys ordii	79.89	0.00e+00	1473.00
IUUC-Dme-031766	Drosophila melanogaster	58.69	1.00e-158	554.00
IUUC-Fca-036187	Felis catus	96.74	0.00e+00	1808.00
IUUC-Gmo-038473	Gadus morhua	76.91	0.00e+00	742.00
IUUC-Gga-040501	Gallus gallus	90.33	0.00e+00	1688.00
IUUC-Gac-042335	Gasterosteus aculeatus	70.58	0.00e+00	1264.00
IUUC-Ggo-045380	Gorilla gorilla	92.24	0.00e+00	1769.00
IUUC-Hsa-046925	Homo sapiens	92.80	0.00e+00	1777.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	92.40	0.00e+00	1696.00
IUUC-Lch-050325	Latimeria chalumnae	84.03	0.00e+00	1555.00
IUUC-Loc-052231	Lepisosteus oculatus	80.34	0.00e+00	1462.00
IUUC-Laf-054490	Loxodonta africana	85.86	0.00e+00	1641.00
IUUC-Mcc-055265	Macaca mulatta	92.01	0.00e+00	1775.00
IUUC-Meu-056676	Macropus eugenii	87.42	0.00e+00	768.00
IUUC-Mmr-061633	Microcebus murinus	84.18	0.00e+00	1532.00
IUUC-Mmu-063089	Mus musculus	91.70	0.00e+00	1699.00
IUUC-Mlu-067470	Myotis lucifugus	94.03	0.00e+00	1766.00
IUUC-Nle-069099	Nomascus leucogenys	86.79	0.00e+00	1179.00
IUUC-Ont-071613	Oreochromis niloticus	68.97	0.00e+00	1300.00
IUUC-Oan-073275	Ornithorhynchus anatinus	88.40	0.00e+00	1667.00
IUUC-Ola-087031	Oryzias latipes	66.57	0.00e+00	1187.00
IUUC-Oga-088201	Otolemur garnettii	87.59	0.00e+00	1526.00
IUUC-Oar-089997	Ovis aries	86.14	0.00e+00	1452.00
IUUC-Ptr-091116	Pan troglodytes	92.70	0.00e+00	1812.00
IUUC-Pan-092132	Papio anubis	92.34	0.00e+00	1161.00
IUUC-Psi-093734	Pelodiscus sinensis	88.74	0.00e+00	1583.00
IUUC-Pma-094347	Petromyzon marinus	71.37	0.00e+00	711.00
IUUC-Pfo-096293	Poecilia formosa	70.09	0.00e+00	1214.00
IUUC-Pab-098491	Pongo abelii	88.12	0.00e+00	1712.00
IUUC-Pca-101004	Procavia capensis	84.16	0.00e+00	939.00
IUUC-Pva-102961	Pteropus vampyrus	70.73	0.00e+00	895.00
IUUC-Rno-105005	Rattus norvegicus	91.98	0.00e+00	1677.00
IUUC-Sha-107646	Sarcophilus harrisii	66.48	0.00e+00	987.00
IUUC-Ssc-115428	Sus scrofa	93.52	0.00e+00	1673.00
IUUC-Tgu-116776	Taeniopygia guttata	90.27	0.00e+00	1686.00
IUUC-Tru-118180	Takifugu rubripes	68.88	0.00e+00	1273.00
IUUC-Tsy-119468	Tarsius syrichta	87.80	0.00e+00	766.00
IUUC-Tni-120196	Tetraodon nigroviridis	69.35	0.00e+00	1267.00
IUUC-Ttr-128360	Tursiops truncatus	84.51	0.00e+00	1005.00
IUUC-Xtr-132956	Xenopus tropicalis	79.85	0.00e+00	1459.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence