iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028390

Ensembl Protein ID

ENSDARP00000109205.1

UniProt Accession

A9LMC0; Q5RIJ2; DPF3_DANRE

Genbank Protein ID

ABX10892.1; CAI11958.2

Protein Name

Zinc finger protein DPF3

Genbank Nucleotide ID

EU245032; BX255881

Gene Name

dpf3; si:ch211-268e23.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000025309.9	ENSDART00000034245.6	ENSDARP00000032706.6
ENSDARG00000025309.9	ENSDART00000123387.2	ENSDARP00000109205.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.90e-13	51.3	331	378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           k+C +Cg +++d+ +l+ C++C++ +H  Clk++  ++ p+ + w C  C+
   Q: 331  KSCSLCGTSENDD-QLLFCDDCDRGYHMYCLKPP-MTQPPEGS-WSCHLCQ 378
           78********987.7*******************.66666665.******7 PP

Organism

Danio rerio

Functional Description
(View)

Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity). Plays an essential role in heart and skeletal muscle development.

Protein Sequence
(Fasta)

MATVIQNPLK ALGDQFYREA IEHCRSYNAR LCAERSVRMP FLDSQTGVAQ NNCYIWMEKR 60
HRGPGMAAGQ MYTYPARCWR KKRRLHTPLD PQLRLCELRL EAELMAKREA PQTEATALEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACTGAGGTC CGTATTGGCT GTTTTTCTTT CACAAGGATC CCAAAGAACT CAGATTTGGA 60
ATATTGGGTT ACAGTGTGGC AAAATGGCGA CTGTCATTCA GAATCCGCTG AAAGCGTAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025750--Requiem/DPF_N_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00628--PHD
PF14051--Requiem_N

SMART

SM00249--PHD

Gene Ontology

GO:0016514--C:SWI/SNF complex
GO:0042393--F:histone binding
GO:0008270--F:zinc ion binding
GO:0055008--P:cardiac muscle tissue morphogenesis
GO:0006338--P:chromatin remodeling
GO:0016569--P:covalent chromatin modification
GO:0048644--P:muscle organ morphogenesis
GO:0007399--P:nervous system development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

dre:562738

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001805	Ailuropoda melanoleuca	64.34	5.00e-132	464.00
IUUC-Apl-003424	Anas platyrhynchos	68.91	7.00e-141	493.00
IUUC-Aca-005022	Anolis carolinensis	68.72	7.00e-145	506.00
IUUC-Ame-011868	Astyanax mexicanus	90.10	0.00e+00	635.00
IUUC-Bta-013164	Bos taurus	67.27	2.00e-139	488.00
IUUC-Cja-019565	Callithrix jacchus	68.80	2.00e-143	502.00
IUUC-Cpo-021757	Cavia porcellus	68.80	5.00e-143	500.00
IUUC-Cin-025528	Ciona intestinalis	40.05	4.00e-77	281.00
IUUC-Eca-034251	Equus caballus	68.80	2.00e-143	502.00
IUUC-Fca-036522	Felis catus	63.03	1.00e-128	452.00
IUUC-Fal-036898	Ficedula albicollis	68.46	2.00e-140	491.00
IUUC-Gmo-039263	Gadus morhua	73.75	2.00e-158	551.00
IUUC-Gga-041265	Gallus gallus	61.50	3.00e-136	478.00
IUUC-Gac-042467	Gasterosteus aculeatus	72.27	3.00e-170	591.00
IUUC-Ggo-045528	Gorilla gorilla	70.79	4.00e-146	511.00
IUUC-Hsa-046855	Homo sapiens	68.80	2.00e-143	502.00
IUUC-Loc-052830	Lepisosteus oculatus	82.60	5.00e-163	566.00
IUUC-Laf-053772	Loxodonta africana	59.54	3.00e-133	468.00
IUUC-Mcc-054671	Macaca mulatta	68.16	2.00e-137	481.00
IUUC-Mga-059248	Meleagris gallopavo	59.23	3.00e-129	454.00
IUUC-Mmr-061299	Microcebus murinus	68.80	2.00e-143	502.00
IUUC-Mdo-061983	Monodelphis domestica	70.00	4.00e-140	491.00
IUUC-Mmu-063734	Mus musculus	68.80	3.00e-143	501.00
IUUC-Mpu-066235	Mustela putorius furo	68.16	2.00e-137	482.00
IUUC-Mlu-067198	Myotis lucifugus	63.64	8.00e-128	450.00
IUUC-Ont-071993	Oreochromis niloticus	84.11	5.00e-162	563.00
IUUC-Oga-088159	Otolemur garnettii	59.26	1.00e-131	463.00
IUUC-Oar-090218	Ovis aries	67.01	2.00e-138	485.00
IUUC-Pan-092749	Papio anubis	68.80	2.00e-143	502.00
IUUC-Psi-093080	Pelodiscus sinensis	67.60	4.00e-139	488.00
IUUC-Pfo-096125	Poecilia formosa	83.09	2.00e-161	561.00
IUUC-Tgu-117306	Taeniopygia guttata	70.26	7.00e-144	503.00
IUUC-Tru-118192	Takifugu rubripes	70.65	4.00e-163	567.00
IUUC-Tni-120874	Tetraodon nigroviridis	76.44	1.00e-144	506.00
IUUC-Xtr-131937	Xenopus tropicalis	61.17	5.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence