iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021671

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02019885

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000008618.3	ENSCPOT00000008696.2	ENSCPOP00000007744.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-135	450.9	614	945

Active Site

Position(s)	Description	Evidence
915	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 614  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 702
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 703  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 786
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 787  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 875
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 876  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 945
           *********************************************************************8 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

SNFIVFFFQQ GESRILRVKV VSGIDLAKKD IFGASDPYVK LSLYVADENR ELALVQTKTI 60
KKTLNPKWNE EFYFRVNPSN HRLLFEVFDE NRLTRDDFLG QVDVPLSHLP TEDPTMERPY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTAACTTTA TTGTTTTCTT TTTCCAACAG GGAGAATCCC GTATTCTCAG AGTGAAAGTT 60
GTTTCTGGAA TTGATCTTGC CAAAAAGGAC ATCTTTGGTG CCAGGTATGT CTTGTTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0044325--F:ion channel binding
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	97.94	0.00e+00	1705.00
IUUC-Apl-003893	Anas platyrhynchos	92.36	0.00e+00	1660.00
IUUC-Aca-004744	Anolis carolinensis	89.25	0.00e+00	1607.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	1.00e-163	570.00
IUUC-Afl-008713	Aspergillus flavus	49.01	2.00e-161	562.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	1.00e-163	570.00
IUUC-Ani-009259	Aspergillus nidulans	48.45	4.00e-162	565.00
IUUC-Ang-009738	Aspergillus niger	49.33	4.00e-162	565.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	1.00e-101	362.00
IUUC-Ate-010529	Aspergillus terreus	49.42	4.00e-164	572.00
IUUC-Ame-010810	Astyanax mexicanus	86.58	0.00e+00	1031.00
IUUC-Bgr-012148	Blumeria graminis	47.91	2.00e-154	539.00
IUUC-Bta-012679	Bos taurus	95.79	0.00e+00	1571.00
IUUC-Bci-013785	Botrytis cinerea	47.99	6.00e-156	544.00
IUUC-Cel-018564	Caenorhabditis elegans	52.53	0.00e+00	632.00
IUUC-Cja-018732	Callithrix jacchus	95.95	0.00e+00	1774.00
IUUC-Cfa-021226	Canis familiaris	96.15	0.00e+00	1751.00
IUUC-Csa-023344	Chlorocebus sabaeus	94.38	0.00e+00	1754.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	743.00
IUUC-Cin-025157	Ciona intestinalis	55.17	0.00e+00	971.00
IUUC-Csv-026098	Ciona savignyi	59.04	0.00e+00	654.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	48.34	2.00e-155	542.00
IUUC-Dre-027770	Danio rerio	77.80	0.00e+00	1405.00
IUUC-Dno-029466	Dasypus novemcinctus	95.94	0.00e+00	1776.00
IUUC-Dor-030138	Dipodomys ordii	94.64	0.00e+00	1643.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	4.00e-160	558.00
IUUC-Dme-032166	Drosophila melanogaster	67.09	0.00e+00	711.00
IUUC-Ete-033145	Echinops telfairi	90.93	0.00e+00	1277.00
IUUC-Eca-033445	Equus caballus	96.00	0.00e+00	1568.00
IUUC-Eeu-035247	Erinaceus europaeus	90.73	0.00e+00	1499.00
IUUC-Fca-035489	Felis catus	92.76	0.00e+00	1506.00
IUUC-Fal-037604	Ficedula albicollis	89.90	0.00e+00	1666.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	8.00e-159	554.00
IUUC-Fso-038393	Fusarium solani	47.41	1.00e-153	537.00
IUUC-Gmo-039674	Gadus morhua	76.16	0.00e+00	1355.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	6.00e-156	544.00
IUUC-Gga-040703	Gallus gallus	91.78	0.00e+00	1697.00
IUUC-Gac-042020	Gasterosteus aculeatus	77.96	0.00e+00	1395.00
IUUC-Ggo-045332	Gorilla gorilla	98.36	0.00e+00	1731.00
IUUC-Hsa-045968	Homo sapiens	96.35	0.00e+00	1768.00
IUUC-Lch-050443	Latimeria chalumnae	85.07	0.00e+00	1428.00
IUUC-Lpe-050915	Leersia perrieri	44.33	1.00e-91	333.00
IUUC-Loc-052662	Lepisosteus oculatus	79.88	0.00e+00	1411.00
IUUC-Laf-053850	Loxodonta africana	98.62	0.00e+00	1792.00
IUUC-Mcc-055821	Macaca mulatta	96.14	0.00e+00	1761.00
IUUC-Meu-056712	Macropus eugenii	84.18	0.00e+00	780.00
IUUC-Mor-057097	Magnaporthe oryzae	47.75	2.00e-156	546.00
IUUC-Mla-058996	Melampsora laricipopulina	54.15	1.00e-149	523.00
IUUC-Mvi-060395	Microbotryum violaceum	53.91	6.00e-150	524.00
IUUC-Mmr-060798	Microcebus murinus	92.20	0.00e+00	1637.00
IUUC-Mdo-062173	Monodelphis domestica	92.95	0.00e+00	1745.00
IUUC-Mmu-064136	Mus musculus	95.63	0.00e+00	1744.00
IUUC-Mpu-066765	Mustela putorius furo	96.04	0.00e+00	1745.00
IUUC-Mlu-067565	Myotis lucifugus	92.72	0.00e+00	1539.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	6.00e-164	571.00
IUUC-Ncr-068918	Neurospora crassa	47.40	2.00e-157	549.00
IUUC-Nle-069070	Nomascus leucogenys	92.40	0.00e+00	1671.00
IUUC-Opr-071044	Ochotona princeps	99.20	0.00e+00	1205.00
IUUC-Ont-072044	Oreochromis niloticus	76.73	0.00e+00	1426.00
IUUC-Oan-073032	Ornithorhynchus anatinus	90.97	0.00e+00	1400.00
IUUC-Ocu-074160	Oryctolagus cuniculus	97.24	0.00e+00	1736.00
IUUC-Oba-075252	Oryza barthii	44.58	1.00e-90	329.00
IUUC-Oin-079663	Oryza indica	44.58	1.00e-90	330.00
IUUC-Olo-080326	Oryza longistaminata	44.33	1.00e-89	326.00
IUUC-Oni-082342	Oryza nivara	44.58	1.00e-90	330.00
IUUC-Oru-084559	Oryza rufipogon	44.58	1.00e-90	330.00
IUUC-Ola-087467	Oryzias latipes	78.10	0.00e+00	1412.00
IUUC-Oga-088460	Otolemur garnettii	91.22	0.00e+00	1541.00
IUUC-Oar-090198	Ovis aries	95.83	0.00e+00	1733.00
IUUC-Ptr-090939	Pan troglodytes	96.35	0.00e+00	1768.00
IUUC-Pan-092284	Papio anubis	96.15	0.00e+00	1765.00
IUUC-Psi-093645	Pelodiscus sinensis	92.19	0.00e+00	1689.00
IUUC-Pma-094364	Petromyzon marinus	82.63	0.00e+00	860.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.37	3.00e-163	568.00
IUUC-Pfo-096768	Poecilia formosa	91.16	0.00e+00	962.00
IUUC-Pab-098088	Pongo abelii	96.46	0.00e+00	1768.00
IUUC-Pca-100714	Procavia capensis	76.50	0.00e+00	1317.00
IUUC-Pva-102354	Pteropus vampyrus	98.25	0.00e+00	1699.00
IUUC-Pgr-103620	Puccinia graminis	53.53	7.00e-148	517.00
IUUC-Ptt-103806	Puccinia triticina	53.38	9.00e-123	434.00
IUUC-Pte-104016	Pyrenophora teres	49.00	5.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	5.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	94.90	0.00e+00	1723.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	7.00e-164	570.00
IUUC-Sha-107482	Sarcophilus harrisii	94.10	0.00e+00	1571.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.49	1.00e-157	550.00
IUUC-Stu-112582	Solanum tuberosum	35.81	3.00e-55	210.00
IUUC-Ssc-115950	Sus scrofa	71.12	0.00e+00	1172.00
IUUC-Tgu-117130	Taeniopygia guttata	92.60	0.00e+00	1699.00
IUUC-Tru-118610	Takifugu rubripes	79.18	0.00e+00	1436.00
IUUC-Tsy-119492	Tarsius syrichta	93.82	0.00e+00	1639.00
IUUC-Tni-120113	Tetraodon nigroviridis	73.75	0.00e+00	1328.00
IUUC-Tre-122203	Trichoderma reesei	47.45	5.00e-152	531.00
IUUC-Tvi-122595	Trichoderma virens	47.27	2.00e-154	539.00
IUUC-Tbe-127441	Tupaia belangeri	94.61	0.00e+00	801.00
IUUC-Ttr-128235	Tursiops truncatus	91.49	0.00e+00	1558.00
IUUC-Vda-129753	Verticillium dahliae	47.85	9.00e-157	547.00
IUUC-Vpa-130544	Vicugna pacos	79.59	0.00e+00	908.00
IUUC-Xtr-132859	Xenopus tropicalis	88.59	0.00e+00	1616.00
IUUC-Xma-133797	Xiphophorus maculatus	80.16	0.00e+00	1426.00
IUUC-Yli-134668	Yarrowia lipolytica	46.42	2.00e-162	565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence