iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062515

Ensembl Protein ID

ENSMODP00000036939.1

UniProt Accession

F6RNA3; F6RNA3_MONDO

Protein Name

Uncharacterized protein

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000018280.3	ENSMODT00000038535.2	ENSMODP00000036939.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-10	41.4	403	454

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++ ydy+++ +de ++   d+++ i  e  degW++g    +g+ GlfP+n+v+ l
   Q: 403  IAVYDYQGEGSDEISFDPDDTITDI--EMIDEGWWRG--RCHGRFGLFPANYVQLL 454
           689*********************9..9*********..8*************976 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRKE HINIHQLRNK 60
VSEEHDVLKK KEMEAGPKAS HGYGGRFGVE RDRMDKSALG HEYVADVEKH SSQTDAAKGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAAGT CAGTGGTGGG GCATGATGTG TCTGTTTCTG TGGAAACACA AGGTGACGAC 60
TGGGACACAG ATCCTGACTT TGTAGTGAGT GTGGAAGTAT CACGGGCCCA AATAGGTAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	66.60	1.00e-172	599.00
IUUC-Ame-011504	Astyanax mexicanus	45.86	5.00e-103	368.00
IUUC-Bta-012591	Bos taurus	71.23	1.00e-138	486.00
IUUC-Cja-019982	Callithrix jacchus	66.80	1.00e-168	586.00
IUUC-Cfa-020262	Canis familiaris	64.83	7.00e-163	566.00
IUUC-Cpo-021362	Cavia porcellus	91.06	9.00e-131	460.00
IUUC-Csa-023911	Chlorocebus sabaeus	67.48	6.00e-169	587.00
IUUC-Cin-025677	Ciona intestinalis	56.02	1.00e-66	247.00
IUUC-Dre-028127	Danio rerio	71.36	3.00e-93	335.00
IUUC-Dor-030437	Dipodomys ordii	57.37	4.00e-142	498.00
IUUC-Dme-031931	Drosophila melanogaster	51.92	3.00e-68	252.00
IUUC-Ete-033160	Echinops telfairi	60.71	3.00e-127	448.00
IUUC-Eca-033269	Equus caballus	66.47	2.00e-165	575.00
IUUC-Eeu-035032	Erinaceus europaeus	50.38	7.00e-86	311.00
IUUC-Fca-035999	Felis catus	65.61	3.00e-167	581.00
IUUC-Fal-037107	Ficedula albicollis	50.19	1.00e-121	429.00
IUUC-Gga-040335	Gallus gallus	67.49	3.00e-105	375.00
IUUC-Gac-042253	Gasterosteus aculeatus	68.08	3.00e-86	312.00
IUUC-Ggo-044505	Gorilla gorilla	68.71	1.00e-168	585.00
IUUC-Hsa-046728	Homo sapiens	72.42	3.00e-140	491.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	70.13	3.00e-118	418.00
IUUC-Lch-050221	Latimeria chalumnae	76.85	2.00e-98	352.00
IUUC-Laf-054202	Loxodonta africana	65.03	2.00e-162	565.00
IUUC-Mcc-055824	Macaca mulatta	66.46	7.00e-163	566.00
IUUC-Mmr-061281	Microcebus murinus	62.50	6.00e-144	503.00
IUUC-Mmu-064341	Mus musculus	66.40	4.00e-166	577.00
IUUC-Mpu-066565	Mustela putorius furo	73.56	9.00e-132	463.00
IUUC-Mlu-066942	Myotis lucifugus	66.47	9.00e-162	563.00
IUUC-Nle-069436	Nomascus leucogenys	67.08	7.00e-168	583.00
IUUC-Opr-070288	Ochotona princeps	61.48	4.00e-136	478.00
IUUC-Ont-071712	Oreochromis niloticus	71.36	5.00e-89	322.00
IUUC-Ocu-074686	Oryctolagus cuniculus	66.06	8.00e-160	556.00
IUUC-Ola-086894	Oryzias latipes	57.34	3.00e-91	328.00
IUUC-Oga-088585	Otolemur garnettii	61.46	3.00e-155	541.00
IUUC-Oar-089686	Ovis aries	68.48	5.00e-174	603.00
IUUC-Ptr-090461	Pan troglodytes	72.98	4.00e-141	494.00
IUUC-Pan-091887	Papio anubis	67.56	1.00e-167	582.00
IUUC-Psi-093785	Pelodiscus sinensis	51.77	1.00e-141	496.00
IUUC-Pma-094161	Petromyzon marinus	61.73	1.00e-54	207.00
IUUC-Pfo-097391	Poecilia formosa	67.61	4.00e-88	318.00
IUUC-Pab-098222	Pongo abelii	66.67	3.00e-166	578.00
IUUC-Pca-100668	Procavia capensis	66.60	2.00e-159	555.00
IUUC-Pva-102767	Pteropus vampyrus	59.79	1.00e-134	473.00
IUUC-Rno-106001	Rattus norvegicus	67.21	9.00e-168	583.00
IUUC-Sha-106912	Sarcophilus harrisii	62.54	3.00e-151	528.00
IUUC-Sar-113338	Sorex araneus	59.59	5.00e-139	487.00
IUUC-Ssc-116027	Sus scrofa	67.52	9.00e-170	589.00
IUUC-Tgu-117472	Taeniopygia guttata	55.89	1.00e-142	499.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence