iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164087.7	ENST00000296484.6	ENSP00000296484.2
ENSG00000164087.7	ENST00000394970.6	ENSP00000378421.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.40e-58	192.0	144	182
UBD/Beta-Prp	9.90e-81	272.8	16	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H ++v+c +f +d +l+vs+sdD+t+k+WD ++  +++s
   Q: 144  HINWVRCAKFsPDgRLIVSASDDKTVKLWDKSSRECVHS 182
           999********999****************999888875 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           kg h + +tcv+fs ++++la+gs+d+++ vw +++++   ++ gh+++vt+v+fsp+g +l++gs+D+t+++w ++      ++++h+++v
   Q: 16   KG-HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATV 106
           44.5557777***999999*******************************************************7775555567899***** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfd 189
           +s++f+ +g+++v++s+d+t++vw ++ ++ l   ls+h  +v+c++++pdg+l+vs+s+D+tv+lWd ++ ++++   + h + v+ ++f+
   Q: 107  RSVHFCSDGQSFVTASDDKTVKVWATHRQKFLF-SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFH 196
           ************************999999998.9*******************************************98.*********** PP
   S: 190  sngkelvsgsldgtvklwdlqtgecvrtl 218
           ++g++++++++d+tvk+wd++t + ++ +
   Q: 197  PSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
           *********************99988876 PP

Organism

Homo sapiens

Functional Description
(View)

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.

Protein Sequence
(Fasta)

MAAPCAEDPS LERHFKGHRD AVTCVDFSIN TKQLASGSMD SCLMVWHMKP QSRAYRFTGH 60
KDAVTCVNFS PSGHLLASGS RDKTVRIWVP NVKGESTVFR AHTATVRSVH FCSDGQSFVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCTGGTGG GGTGAACCCT TCATCCTGGG TCTTTTAATT TCTCAGGCGG AACGAGTGGC 60
GGCGGACAGA GGCTTTTGGC TGCGCTGTCT GTGGGTTGTC TGGGCTTGGG GAACTGGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-1186--Ciliopathy
KW-0970--Cilium biogenesis/degradation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0242--Dwarfism
KW-1063--Hypotrichosis
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0000922--C:spindle pole
GO:0003431--P:growth plate cartilage chondrocyte development
GO:0007052--P:mitotic spindle organization
GO:1905515--P:non-motile cilium assembly
GO:0010825--P:positive regulation of centrosome duplication
GO:0007283--P:spermatogenesis

KEGG

hsa:25886

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001513	Ailuropoda melanoleuca	94.76	0.00e+00	761.00
IUUC-Apl-003466	Anas platyrhynchos	77.75	0.00e+00	647.00
IUUC-Aca-004323	Anolis carolinensis	70.95	0.00e+00	631.00
IUUC-Bta-012484	Bos taurus	93.61	0.00e+00	793.00
IUUC-Cja-019067	Callithrix jacchus	95.30	0.00e+00	797.00
IUUC-Cfa-020439	Canis familiaris	93.37	0.00e+00	794.00
IUUC-Cpo-021403	Cavia porcellus	91.27	0.00e+00	781.00
IUUC-Cre-022724	Chlamydomonas reinhardtii	50.89	2.00e-112	399.00
IUUC-Csa-023479	Chlorocebus sabaeus	98.10	0.00e+00	717.00
IUUC-Cho-024354	Choloepus hoffmanni	88.18	4.00e-115	407.00
IUUC-Cin-025258	Ciona intestinalis	72.31	9.00e-142	496.00
IUUC-Csv-025955	Ciona savignyi	64.38	1.00e-146	512.00
IUUC-Dno-029467	Dasypus novemcinctus	78.40	7.00e-129	452.00
IUUC-Dor-030399	Dipodomys ordii	89.93	0.00e+00	768.00
IUUC-Eca-034425	Equus caballus	93.77	0.00e+00	755.00
IUUC-Eeu-034607	Erinaceus europaeus	81.33	0.00e+00	644.00
IUUC-Fca-035627	Felis catus	95.26	0.00e+00	775.00
IUUC-Fal-037381	Ficedula albicollis	74.20	0.00e+00	630.00
IUUC-Gmo-038489	Gadus morhua	68.01	1.00e-160	558.00
IUUC-Gga-040559	Gallus gallus	75.00	1.00e-180	625.00
IUUC-Gac-041453	Gasterosteus aculeatus	69.78	1.00e-171	596.00
IUUC-Ggo-044773	Gorilla gorilla	99.26	0.00e+00	801.00
IUUC-Itr-048560	Ictidomys tridecemlineatus	93.27	0.00e+00	795.00
IUUC-Lch-050558	Latimeria chalumnae	68.58	2.00e-177	615.00
IUUC-Loc-052836	Lepisosteus oculatus	69.20	2.00e-176	612.00
IUUC-Laf-053974	Loxodonta africana	84.62	0.00e+00	681.00
IUUC-Mcc-055494	Macaca mulatta	96.06	0.00e+00	769.00
IUUC-Meu-056646	Macropus eugenii	75.17	9.00e-131	460.00
IUUC-Mga-059295	Meleagris gallopavo	67.56	6.00e-173	600.00
IUUC-Mmr-061040	Microcebus murinus	94.35	0.00e+00	803.00
IUUC-Mdo-062519	Monodelphis domestica	78.05	4.00e-176	610.00
IUUC-Mmu-063759	Mus musculus	94.00	4.00e-172	597.00
IUUC-Mpu-066442	Mustela putorius furo	93.37	0.00e+00	771.00
IUUC-Mlu-068163	Myotis lucifugus	92.12	0.00e+00	773.00
IUUC-Nle-070160	Nomascus leucogenys	98.77	0.00e+00	803.00
IUUC-Opr-070192	Ochotona princeps	90.32	0.00e+00	672.00
IUUC-Ont-072539	Oreochromis niloticus	72.17	1.00e-148	519.00
IUUC-Oan-072834	Ornithorhynchus anatinus	61.59	6.00e-113	400.00
IUUC-Ocu-074624	Oryctolagus cuniculus	92.68	0.00e+00	719.00
IUUC-Ola-087268	Oryzias latipes	62.88	2.00e-159	555.00
IUUC-Oga-088964	Otolemur garnettii	87.07	0.00e+00	740.00
IUUC-Oar-090202	Ovis aries	93.77	0.00e+00	752.00
IUUC-Ptr-091164	Pan troglodytes	100.00	0.00e+00	796.00
IUUC-Pan-092805	Papio anubis	97.29	0.00e+00	712.00
IUUC-Psi-093359	Pelodiscus sinensis	81.54	4.00e-163	566.00
IUUC-Pma-094425	Petromyzon marinus	63.24	9.00e-165	573.00
IUUC-Ppa-095677	Physcomitrella patens	46.05	4.00e-81	294.00
IUUC-Pfo-096741	Poecilia formosa	59.21	1.00e-155	542.00
IUUC-Pab-098376	Pongo abelii	99.02	0.00e+00	843.00
IUUC-Pca-101122	Procavia capensis	89.43	0.00e+00	759.00
IUUC-Pva-103104	Pteropus vampyrus	72.97	1.00e-168	585.00
IUUC-Rno-105282	Rattus norvegicus	87.03	0.00e+00	663.00
IUUC-Sha-106840	Sarcophilus harrisii	80.75	2.00e-117	414.00
IUUC-Smo-108731	Selaginella moellendorffii	44.52	3.00e-78	285.00
IUUC-Sar-113262	Sorex araneus	64.62	7.00e-146	510.00
IUUC-Ssc-115392	Sus scrofa	92.86	0.00e+00	656.00
IUUC-Tgu-117340	Taeniopygia guttata	73.75	2.00e-177	614.00
IUUC-Tsy-119404	Tarsius syrichta	86.53	0.00e+00	723.00
IUUC-Tni-120713	Tetraodon nigroviridis	69.91	5.00e-136	478.00
IUUC-Tbe-127788	Tupaia belangeri	68.30	1.00e-157	549.00
IUUC-Ttr-128608	Tursiops truncatus	89.68	0.00e+00	722.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence