iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041752

UUCD1 version

UUC-GaA-01226

Ensembl Protein ID

ENSGACP00000021863.1

UniProt Accession

G3PW74; G3PW74_GASAC

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000016551.1	ENSGACT00000021904.1	ENSGACP00000021863.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-113	379.7	156	678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++le     +    ++++k +l++s+qkl++ lw k++ ++v p++l++ +k+++++f+gy+
   Q: 156  TGLKNIGNTCYMNAALQALSNCPPLTQFFLE-----CGGMVRTDKKPALCRSYQKLVSDLWhKNRPSYVVPTNLFQGIKAINPMFRGYS 239
           7******************************.....9999999******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde................................................ 129
           qqD+qEfl++l+dql+eelk+ + +p++++++ +  + ++e                                                
   Q: 240  QQDSQEFLRCLMDQLHEELKEAQPEPYDQSNGVTVDDGPEEdnpcescgsseradnevqggnatkedtneaemliteeneiqsnrewqk 328
           *********************99999999999987777777899********************************************* PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 329  eknmindlyrsgvngvmggstgvdmdkdvdtttettpiissqgaikvqgrtsdsfpdiqisnstrpqspvpteghipkmsssppkaasg 417
           ***************************************************************************************** PP
   S: 130  .................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke................ 185
                             ++k +kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+d+slp+pgke+ +k+                
   Q: 418  wsslipshkkavttfsaPKSKRQKKYRSVISDVFDGTIVSSVQCLTCDRVSVTLENFQDISLPIPGKEDLAKLhssthqtslvkagscg 506
           ****************988999999*******************************************99888**************** PP
   S: 186  .........................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
                                    +lqdcL++f++++el+g+n+y+cekckk+++ +k +k+++lPe+L++hLkRf  ++e ++++ki
   Q: 507  eayapqgwisfvmeyikswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKMQSLPEILCVHLKRF--RHELMFSTKI 593
           *****************************************************************************..9999****** PP
   S: 250  nkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
            ++v+fple Ldl+pf+++++++q  +++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e+ v++   ++aYvlfYk
   Q: 594  CTHVSFPLEgLDLQPFLAKDSSAQ--TTNYDLLSVICHHGTASSGHYIAYCRNDLNNlWYEFDDQSVTEVSESCVQN---AEAYVLFYK 677
           *******************88877..9**************************87778*******************...********9 PP
   S: 337  r 337
           +
   Q: 678  K 678
           8 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MLPASGCDCP HLDCVGEITK EELIQKSHGQ CQDCKVGGPN LWACLENGCA YVGCGESHTD 60
HSTVHSQETR HNLTVNLTTL RVWCYACGKE VFLERKLGPH SPHGTSKPLP SPQNAGQDNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGGGACGG GAACGGGCAA CGGCTATCGT TAATGTGACG GATTGCCCTC TAAAGAATGG 60
CGTTAAAGTC ACGCTGAATC TACGCGTTTA CACATCAACG TACAGCCTCG ATCCTCGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	69.45	0.00e+00	1280.00
IUUC-Apl-003987	Anas platyrhynchos	69.28	0.00e+00	1233.00
IUUC-Aca-004713	Anolis carolinensis	67.73	0.00e+00	1239.00
IUUC-Bta-013132	Bos taurus	69.82	0.00e+00	1293.00
IUUC-Cja-018811	Callithrix jacchus	69.86	0.00e+00	1285.00
IUUC-Cfa-021158	Canis familiaris	69.45	0.00e+00	1279.00
IUUC-Cpo-021910	Cavia porcellus	64.11	0.00e+00	1135.00
IUUC-Csa-023130	Chlorocebus sabaeus	70.17	0.00e+00	1283.00
IUUC-Cho-024383	Choloepus hoffmanni	49.47	2.00e-106	380.00
IUUC-Dre-028639	Danio rerio	80.31	0.00e+00	1451.00
IUUC-Dno-029416	Dasypus novemcinctus	69.60	0.00e+00	1259.00
IUUC-Ete-032994	Echinops telfairi	58.71	4.00e-123	435.00
IUUC-Eca-034248	Equus caballus	70.08	0.00e+00	1297.00
IUUC-Eeu-035357	Erinaceus europaeus	54.03	0.00e+00	873.00
IUUC-Fca-036013	Felis catus	67.86	0.00e+00	1234.00
IUUC-Fal-037509	Ficedula albicollis	69.67	0.00e+00	1264.00
IUUC-Gmo-038944	Gadus morhua	82.93	0.00e+00	1490.00
IUUC-Gga-040647	Gallus gallus	69.68	0.00e+00	1244.00
IUUC-Hsa-045694	Homo sapiens	70.00	0.00e+00	1273.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	69.67	0.00e+00	1278.00
IUUC-Lch-050400	Latimeria chalumnae	68.04	0.00e+00	1217.00
IUUC-Loc-052616	Lepisosteus oculatus	76.90	0.00e+00	1406.00
IUUC-Laf-053493	Loxodonta africana	69.41	0.00e+00	1284.00
IUUC-Mcc-055542	Macaca mulatta	70.17	0.00e+00	1287.00
IUUC-Meu-056645	Macropus eugenii	60.82	0.00e+00	1055.00
IUUC-Mmr-061241	Microcebus murinus	66.99	0.00e+00	1244.00
IUUC-Mmu-063786	Mus musculus	69.61	0.00e+00	1272.00
IUUC-Mlu-067732	Myotis lucifugus	68.64	0.00e+00	1279.00
IUUC-Nle-069528	Nomascus leucogenys	69.42	0.00e+00	1277.00
IUUC-Opr-070606	Ochotona princeps	65.87	0.00e+00	1157.00
IUUC-Ont-071495	Oreochromis niloticus	91.12	0.00e+00	1655.00
IUUC-Ocu-074457	Oryctolagus cuniculus	68.47	0.00e+00	1281.00
IUUC-Ola-086739	Oryzias latipes	86.88	0.00e+00	1647.00
IUUC-Oga-088720	Otolemur garnettii	69.85	0.00e+00	1288.00
IUUC-Oar-089921	Ovis aries	69.97	0.00e+00	1297.00
IUUC-Ptr-090526	Pan troglodytes	70.00	0.00e+00	1275.00
IUUC-Pan-092396	Papio anubis	69.99	0.00e+00	1287.00
IUUC-Psi-092971	Pelodiscus sinensis	69.84	0.00e+00	1293.00
IUUC-Pfo-097415	Poecilia formosa	85.12	0.00e+00	1569.00
IUUC-Pab-098740	Pongo abelii	70.11	0.00e+00	1291.00
IUUC-Pca-100598	Procavia capensis	65.47	0.00e+00	717.00
IUUC-Pva-102820	Pteropus vampyrus	66.54	0.00e+00	1055.00
IUUC-Rno-104894	Rattus norvegicus	68.50	0.00e+00	1263.00
IUUC-Sha-107244	Sarcophilus harrisii	65.67	0.00e+00	1156.00
IUUC-Sar-113665	Sorex araneus	67.61	0.00e+00	1274.00
IUUC-Ssc-115793	Sus scrofa	70.07	0.00e+00	1264.00
IUUC-Tgu-117487	Taeniopygia guttata	70.53	0.00e+00	1227.00
IUUC-Tru-117694	Takifugu rubripes	83.73	0.00e+00	1599.00
IUUC-Tsy-119598	Tarsius syrichta	61.78	0.00e+00	1054.00
IUUC-Tni-120189	Tetraodon nigroviridis	81.86	0.00e+00	1513.00
IUUC-Tbe-128125	Tupaia belangeri	73.26	2.00e-78	287.00
IUUC-Ttr-128269	Tursiops truncatus	68.27	0.00e+00	1209.00
IUUC-Vpa-130598	Vicugna pacos	68.26	0.00e+00	1253.00
IUUC-Xtr-132044	Xenopus tropicalis	68.65	0.00e+00	1223.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence