iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028245

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

WW domain-containing E3 ubiquitin protein ligase 1

Genbank Nucleotide ID

FP102273

Gene Name

wwp1; si:zfos-281c7.3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000097537.2	ENSDART00000153854.2	ENSDARP00000128654.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.20e-133	444.3	487	819

Active Site

Position(s)	Description	Evidence
788	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 487  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 574
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl l+dle++dpe+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk++G+n++Vt+eNkeeY+ l++e
   Q: 575  GFSLPFYKRMLSKKLILKDLESIDPEFYNSLIWIRDN---NIEECGLEMFFSVDMEILGKISSHDLKEDGANVQVTEENKEEYIGLMAE 660
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g+++q++af +Gfnev+pl++l++F+e+ele+++cG++e+d++d++++t y++ yt++s++i+wFw+ ++e+++e r +++qFv
   Q: 661  WRFSRGVESQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRH-YTRNSKQIIWFWQLVKEVDNEVRLRLMQFV 748
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s e+lkekLl+Aieet+gF++
   Q: 749  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQ 819
           *********************************************************************96 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

XNIAPHAPLE FRVWSHHALK ADALLGRAAL DLIGTLRKHD GKLENVREVL PLTAEGKHGV 60
VSTGELTVFL DGLSLDPQLL HSSNTPTASK VHQNGDALHE DADDSSARPQ HRSVNGSDGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATATAGCT CCACACGCGC CGCTGGAGTT CCGGGTCTGG AGTCATCACG CTCTGAAGGC 60
GGATGCGCTG CTGGGTCGAG CCGCACTGGA CCTGATTGGG ACCCTCCGCA AACATGATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	72.72	0.00e+00	1216.00
IUUC-Apl-003310	Anas platyrhynchos	91.98	0.00e+00	1140.00
IUUC-Aca-005388	Anolis carolinensis	71.21	0.00e+00	1216.00
IUUC-Bta-012857	Bos taurus	73.59	0.00e+00	1228.00
IUUC-Cel-018299	Caenorhabditis elegans	67.01	0.00e+00	832.00
IUUC-Cja-019448	Callithrix jacchus	72.45	0.00e+00	1227.00
IUUC-Cfa-020728	Canis familiaris	73.19	0.00e+00	1236.00
IUUC-Cpo-021635	Cavia porcellus	70.76	0.00e+00	1216.00
IUUC-Csa-023805	Chlorocebus sabaeus	89.65	0.00e+00	1110.00
IUUC-Cin-025212	Ciona intestinalis	72.88	0.00e+00	902.00
IUUC-Csv-026256	Ciona savignyi	72.49	0.00e+00	898.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	46.64	1.00e-151	530.00
IUUC-Dno-029618	Dasypus novemcinctus	72.31	0.00e+00	1229.00
IUUC-Dme-032041	Drosophila melanogaster	69.24	0.00e+00	886.00
IUUC-Ete-032779	Echinops telfairi	88.20	0.00e+00	1043.00
IUUC-Eca-033313	Equus caballus	71.98	0.00e+00	1204.00
IUUC-Eeu-035259	Erinaceus europaeus	65.42	0.00e+00	1071.00
IUUC-Fca-035420	Felis catus	72.26	0.00e+00	1231.00
IUUC-Fal-037335	Ficedula albicollis	73.95	0.00e+00	1244.00
IUUC-Fso-038393	Fusarium solani	45.67	4.00e-150	525.00
IUUC-Gmo-039172	Gadus morhua	89.24	0.00e+00	1071.00
IUUC-Gga-040246	Gallus gallus	73.30	0.00e+00	1235.00
IUUC-Gac-042211	Gasterosteus aculeatus	95.38	0.00e+00	1192.00
IUUC-Ggo-045001	Gorilla gorilla	71.67	0.00e+00	1167.00
IUUC-Hsa-046544	Homo sapiens	71.75	0.00e+00	1218.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	72.72	0.00e+00	1237.00
IUUC-Lch-050398	Latimeria chalumnae	92.32	0.00e+00	1139.00
IUUC-Loc-052116	Lepisosteus oculatus	94.24	0.00e+00	1187.00
IUUC-Laf-053551	Loxodonta africana	90.51	0.00e+00	1118.00
IUUC-Mla-058996	Melampsora laricipopulina	45.41	1.00e-149	523.00
IUUC-Mga-059986	Meleagris gallopavo	73.68	0.00e+00	1240.00
IUUC-Mmr-060945	Microcebus murinus	69.67	0.00e+00	1154.00
IUUC-Mdo-063024	Monodelphis domestica	91.32	0.00e+00	1070.00
IUUC-Mmu-063202	Mus musculus	71.85	0.00e+00	1210.00
IUUC-Mpu-065773	Mustela putorius furo	72.63	0.00e+00	1225.00
IUUC-Nle-069188	Nomascus leucogenys	71.79	0.00e+00	1226.00
IUUC-Opr-070965	Ochotona princeps	71.33	0.00e+00	1199.00
IUUC-Ont-072226	Oreochromis niloticus	95.61	0.00e+00	1212.00
IUUC-Oan-073497	Ornithorhynchus anatinus	91.46	0.00e+00	1140.00
IUUC-Ocu-073891	Oryctolagus cuniculus	68.66	0.00e+00	1129.00
IUUC-Ola-087438	Oryzias latipes	94.29	0.00e+00	1195.00
IUUC-Oga-087922	Otolemur garnettii	71.66	0.00e+00	1221.00
IUUC-Oar-089429	Ovis aries	72.77	0.00e+00	1220.00
IUUC-Ptr-090484	Pan troglodytes	71.75	0.00e+00	1218.00
IUUC-Pan-092117	Papio anubis	72.45	0.00e+00	1225.00
IUUC-Psi-093338	Pelodiscus sinensis	73.41	0.00e+00	1248.00
IUUC-Pma-094279	Petromyzon marinus	70.46	0.00e+00	829.00
IUUC-Pfo-096171	Poecilia formosa	95.42	0.00e+00	1199.00
IUUC-Pab-098654	Pongo abelii	87.27	0.00e+00	1073.00
IUUC-Pva-102811	Pteropus vampyrus	69.11	0.00e+00	1156.00
IUUC-Rno-106125	Rattus norvegicus	72.26	0.00e+00	1211.00
IUUC-Sha-107243	Sarcophilus harrisii	91.00	0.00e+00	1121.00
IUUC-Ssc-115368	Sus scrofa	72.24	0.00e+00	1214.00
IUUC-Tgu-117079	Taeniopygia guttata	73.71	0.00e+00	1236.00
IUUC-Tru-118062	Takifugu rubripes	95.61	0.00e+00	1210.00
IUUC-Tsy-119507	Tarsius syrichta	68.00	0.00e+00	1118.00
IUUC-Tni-120151	Tetraodon nigroviridis	95.58	0.00e+00	1190.00
IUUC-Tvi-122595	Trichoderma virens	44.54	8.00e-148	517.00
IUUC-Uma-129332	Ustilago maydis	45.42	5.00e-142	498.00
IUUC-Xtr-132877	Xenopus tropicalis	65.27	0.00e+00	1054.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence