iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046544

UUCD1 version

UUC-HoS-00358

Ensembl Protein ID

ENSP00000427793.1

UniProt Accession

Q9H0M0; O00307; Q5YLC1; Q96BP4; WWP1_HUMAN

Genbank Protein ID

CAB66673.1; AAK94668.1; AAQ22764.1; AAH15380.2; AAH36065.1; AAC51324.1

Protein Name

NEDD4-like E3 ubiquitin-protein ligase WWP1; Atrophin-1-interacting protein 5; HECT-type E3 ubiquitin transferase WWP1; TGIF-interacting ubiquitin ligase 1; WW domain-containing protein 1

Genbank Nucleotide ID

AL136739; AY043361; AY345857; AC083845; BC036065; U96113

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000123124.13	ENST00000517970.5	ENSP00000427793.1
ENSG00000123124.13	ENST00000520453.5	ENSP00000429076.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	19561640; 19047365; 20157612; 20951678; 18806757; 19307600; 17050664; 20694673

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	2.00e-134	449.9	589	921

Active Site

Position(s)	Description	Evidence
890	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+ +s
   Q: 589  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFS 679
           6799*******************************************************98.89**************************** PP
   S: 94   ksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkeg 185
            +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e+r+ +g
   Q: 680  LPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRG 768
           ********************************99...9****************************************************** PP
   S: 186  ikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlg 277
           ++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFvTg++rlPlg
   Q: 769  VQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLG 859
           **************************************************99.*************************************** PP
   S: 278  Gfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Gfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 860  GFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 921
           ************************************************************96 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Protein Sequence
(Fasta)

MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI TKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF QVWSHRTLKA DALLGKATID LKQALLIHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGAGCTCC GCGTGCGGGT TCCGAGTGGC TGCTGGCGGC CTGGGCTGCC GGGGCCGACG 60
CCTGGGTGGC TGCTGCCGCC GCGCCTGCTG CGAGATGGCG ATCTTGGGCG CGGAAGGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0472--Membrane
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007417--P:central nervous system development
GO:0034220--P:ion transmembrane transport
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0007165--P:signal transduction
GO:0046718--P:viral entry into host cell

KEGG

hsa:11059

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	94.58	0.00e+00	1778.00
IUUC-Apl-003310	Anas platyrhynchos	83.21	0.00e+00	1554.00
IUUC-Aca-005388	Anolis carolinensis	80.34	0.00e+00	1467.00
IUUC-Ame-010992	Astyanax mexicanus	90.38	0.00e+00	804.00
IUUC-Bta-012857	Bos taurus	93.49	0.00e+00	1725.00
IUUC-Cja-019448	Callithrix jacchus	97.83	0.00e+00	1849.00
IUUC-Cfa-020728	Canis familiaris	95.23	0.00e+00	1777.00
IUUC-Cpo-021635	Cavia porcellus	89.42	0.00e+00	1687.00
IUUC-Csa-023805	Chlorocebus sabaeus	98.83	0.00e+00	1393.00
IUUC-Cho-024943	Choloepus hoffmanni	84.50	0.00e+00	1221.00
IUUC-Cin-025212	Ciona intestinalis	73.70	0.00e+00	884.00
IUUC-Csv-026256	Ciona savignyi	72.66	0.00e+00	879.00
IUUC-Dre-028245	Danio rerio	70.77	0.00e+00	1183.00
IUUC-Dno-029618	Dasypus novemcinctus	94.90	0.00e+00	1779.00
IUUC-Dor-030665	Dipodomys ordii	78.82	0.00e+00	1189.00
IUUC-Dme-032041	Drosophila melanogaster	71.02	0.00e+00	877.00
IUUC-Ete-032779	Echinops telfairi	94.89	0.00e+00	1120.00
IUUC-Eca-033313	Equus caballus	92.19	0.00e+00	1694.00
IUUC-Eeu-035259	Erinaceus europaeus	85.14	0.00e+00	1574.00
IUUC-Fca-035420	Felis catus	93.82	0.00e+00	1768.00
IUUC-Fal-037335	Ficedula albicollis	82.58	0.00e+00	1535.00
IUUC-Gmo-039172	Gadus morhua	86.44	0.00e+00	1020.00
IUUC-Gga-040246	Gallus gallus	83.01	0.00e+00	1541.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.11	0.00e+00	1129.00
IUUC-Ggo-045001	Gorilla gorilla	99.63	0.00e+00	1667.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	92.57	0.00e+00	1717.00
IUUC-Lch-050398	Latimeria chalumnae	77.32	0.00e+00	1393.00
IUUC-Loc-052116	Lepisosteus oculatus	75.70	0.00e+00	1362.00
IUUC-Laf-053551	Loxodonta africana	92.96	0.00e+00	1709.00
IUUC-Meu-056455	Macropus eugenii	67.30	0.00e+00	823.00
IUUC-Mga-059986	Meleagris gallopavo	82.76	0.00e+00	1544.00
IUUC-Mmr-060945	Microcebus murinus	93.28	0.00e+00	1749.00
IUUC-Mdo-063024	Monodelphis domestica	82.44	0.00e+00	1491.00
IUUC-Mmu-063202	Mus musculus	90.56	0.00e+00	1647.00
IUUC-Mpu-065773	Mustela putorius furo	94.37	0.00e+00	1759.00
IUUC-Mlu-067373	Myotis lucifugus	68.70	0.00e+00	1131.00
IUUC-Nle-069188	Nomascus leucogenys	99.02	0.00e+00	1869.00
IUUC-Opr-070965	Ochotona princeps	88.61	0.00e+00	1642.00
IUUC-Ont-072226	Oreochromis niloticus	91.62	0.00e+00	1135.00
IUUC-Oan-073497	Ornithorhynchus anatinus	85.48	0.00e+00	1550.00
IUUC-Ocu-073891	Oryctolagus cuniculus	89.82	0.00e+00	1647.00
IUUC-Ola-087438	Oryzias latipes	89.11	0.00e+00	1134.00
IUUC-Oga-087922	Otolemur garnettii	94.37	0.00e+00	1761.00
IUUC-Oar-089317	Ovis aries	92.42	0.00e+00	1692.00
IUUC-Ptr-090484	Pan troglodytes	99.89	0.00e+00	1896.00
IUUC-Pan-092117	Papio anubis	98.48	0.00e+00	1863.00
IUUC-Psi-093338	Pelodiscus sinensis	83.53	0.00e+00	1558.00
IUUC-Pma-094279	Petromyzon marinus	74.91	0.00e+00	847.00
IUUC-Pfo-096171	Poecilia formosa	92.47	0.00e+00	1137.00
IUUC-Pab-098654	Pongo abelii	96.62	0.00e+00	1352.00
IUUC-Pca-100501	Procavia capensis	74.32	0.00e+00	933.00
IUUC-Pva-102811	Pteropus vampyrus	80.37	0.00e+00	1435.00
IUUC-Rno-106125	Rattus norvegicus	90.46	0.00e+00	1662.00
IUUC-Sha-107243	Sarcophilus harrisii	85.02	0.00e+00	1564.00
IUUC-Ssc-115368	Sus scrofa	93.41	0.00e+00	1730.00
IUUC-Tgu-117079	Taeniopygia guttata	82.44	0.00e+00	1519.00
IUUC-Tru-118062	Takifugu rubripes	70.79	0.00e+00	1315.00
IUUC-Tsy-119507	Tarsius syrichta	90.56	0.00e+00	1684.00
IUUC-Tni-120151	Tetraodon nigroviridis	91.31	0.00e+00	1122.00
IUUC-Ttr-129260	Tursiops truncatus	84.38	0.00e+00	1519.00
IUUC-Uma-129332	Ustilago maydis	45.93	6.00e-145	508.00
IUUC-Vpa-130390	Vicugna pacos	82.87	0.00e+00	941.00
IUUC-Xtr-132877	Xenopus tropicalis	69.33	0.00e+00	1207.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence