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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047006
UUCD1 version UUC-HoS-00377
Ensembl Protein ID ENSP00000256257.1
UniProt Accession Q9H9V4; Q52LK3; RN122_HUMAN
Genbank Protein ID BAB14115.1; AAH93884.1; AAI01574.1
Protein Name RING finger protein 122
Genbank Nucleotide ID AK022588; BC093884; BC101573
Gene Name RNF122
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000133874.1 ENST00000256257.1 ENSP00000256257.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20553626
Classification
Family E-value Score Start End
E3 activity/RING/RING 9.20e-08 34.2 93 134
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+Cledf  kd++ vlpC+H+fh++Cl kw         +  CP C+
   Q: 93   CAVCLEDFkgKDELGVLPCQHAFHRKCLVKW------LEVRCVCPMCN 134
           ********99778******************......999999****7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May induce necrosis and apoptosis. May play a role in cell viability.
 May induce necrosis and apoptosis. May play a role in cell viability.
Protein Sequence
(Fasta)
MHPFQWCNGC FCGLGLVSTN KSCSMPPISF QDLPLNIYMV IFGTGIFVFM LSLIFCCYFI 60
SKLRNQAQSE RYGYKEVVLK GDAKKLQLYG QTCAVCLEDF KGKDELGVLP CQHAFHRKCL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047006|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTTTCGGAA CCCCAGCCAG CTCACCTCTG CGCCGCTGAA CCCGATCCGA GCCTCCGGCA 60
AAGGTTTTTC CCTCCTCCCC CGGCCGAGGG CTTCTGCAGC CCGGGCACCC CCGCCCCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047006|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:79845
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002066 Ailuropoda melanoleuca 98.06 4.00e-88 316.00
IUUC-Apl-003691 Anas platyrhynchos 83.46 7.00e-65 238.00
IUUC-Aca-004989 Anolis carolinensis 88.39 1.00e-81 294.00
IUUC-Ame-011731 Astyanax mexicanus 81.94 1.00e-76 278.00
IUUC-Bta-012760 Bos taurus 96.60 6.00e-80 289.00
IUUC-Cja-019442 Callithrix jacchus 98.71 9.00e-89 318.00
IUUC-Cfa-021257 Canis familiaris 94.19 8.00e-83 298.00
IUUC-Cpo-021821 Cavia porcellus 90.51 4.00e-81 293.00
IUUC-Csa-023926 Chlorocebus sabaeus 98.71 1.00e-88 318.00
IUUC-Cho-024763 Choloepus hoffmanni 95.74 2.00e-50 189.00
IUUC-Cme-027308 Cyanidioschyzon merolae 36.00 5.00e-09 56.60
IUUC-Dre-028547 Danio rerio 82.58 7.00e-77 278.00
IUUC-Dno-029352 Dasypus novemcinctus 98.06 5.00e-88 316.00
IUUC-Dor-030113 Dipodomys ordii 96.81 1.00e-50 190.00
IUUC-Ete-032590 Echinops telfairi 83.23 1.00e-73 268.00
IUUC-Eca-033808 Equus caballus 97.42 8.00e-88 315.00
IUUC-Eeu-035101 Erinaceus europaeus 96.58 5.00e-80 289.00
IUUC-Fca-035925 Felis catus 98.71 2.00e-88 317.00
IUUC-Gmo-038545 Gadus morhua 87.74 3.00e-79 286.00
IUUC-Gga-041003 Gallus gallus 80.65 3.00e-73 266.00
IUUC-Gac-042633 Gasterosteus aculeatus 62.04 3.00e-41 160.00
IUUC-Itr-048723 Ictidomys tridecemlineatus 96.13 9.00e-86 308.00
IUUC-Loc-052517 Lepisosteus oculatus 89.12 1.00e-74 271.00
IUUC-Laf-053986 Loxodonta africana 96.77 1.00e-85 307.00
IUUC-Mcc-054860 Macaca mulatta 96.69 5.00e-82 296.00
IUUC-Meu-056640 Macropus eugenii 79.86 1.00e-60 224.00
IUUC-Mla-059067 Melampsora laricipopulina 38.30 1.00e-08 55.50
IUUC-Mmr-061260 Microcebus murinus 97.22 6.00e-78 282.00
IUUC-Mdo-062793 Monodelphis domestica 90.48 2.00e-76 277.00
IUUC-Mmu-063949 Mus musculus 96.77 2.00e-87 313.00
IUUC-Mpu-066068 Mustela putorius furo 98.71 2.00e-88 317.00
IUUC-Mlu-067176 Myotis lucifugus 98.06 9.00e-88 315.00
IUUC-Nle-069924 Nomascus leucogenys 97.42 2.00e-87 313.00
IUUC-Opr-070985 Ochotona princeps 96.13 4.00e-85 306.00
IUUC-Ont-071718 Oreochromis niloticus 63.50 5.00e-43 166.00
IUUC-Oan-073727 Ornithorhynchus anatinus 89.73 7.00e-76 275.00
IUUC-Ocu-074776 Oryctolagus cuniculus 96.05 8.00e-84 301.00
IUUC-Obr-076171 Oryza brachyantha 44.26 4.00e-12 64.70
IUUC-Ome-081273 Oryza meridionalis 37.14 2.00e-12 65.50
IUUC-Oni-083042 Oryza nivara 52.27 3.00e-11 62.00
IUUC-Opu-083509 Oryza punctata 32.89 7.00e-13 66.60
IUUC-Oru-084685 Oryza rufipogon 52.27 3.00e-11 62.00
IUUC-Ola-087147 Oryzias latipes 87.10 3.00e-79 286.00
IUUC-Oga-087917 Otolemur garnettii 98.06 3.00e-88 316.00
IUUC-Oar-089739 Ovis aries 94.16 6.00e-83 299.00
IUUC-Ptr-090619 Pan troglodytes 100.00 2.00e-89 321.00
IUUC-Pan-092854 Papio anubis 98.71 1.00e-88 318.00
IUUC-Psi-093254 Pelodiscus sinensis 91.20 3.00e-66 244.00
IUUC-Pma-094708 Petromyzon marinus 66.23 2.00e-24 103.00
IUUC-Pfo-096899 Poecilia formosa 87.10 6.00e-79 286.00
IUUC-Pab-097858 Pongo abelii 99.35 6.00e-89 319.00
IUUC-Pca-100210 Procavia capensis 97.42 2.00e-87 313.00
IUUC-Pva-102677 Pteropus vampyrus 96.77 1.00e-85 308.00
IUUC-Rno-105488 Rattus norvegicus 81.68 9.00e-58 215.00
IUUC-Sha-107332 Sarcophilus harrisii 90.54 4.00e-77 280.00
IUUC-Sja-107935 Schizosaccharomyces japonicus 33.93 1.00e-10 60.80
IUUC-Sar-113175 Sorex araneus 94.44 6.00e-57 211.00
IUUC-Ssc-115896 Sus scrofa 98.06 2.00e-86 310.00
IUUC-Tru-118255 Takifugu rubripes 78.71 7.00e-68 249.00
IUUC-Tsy-119575 Tarsius syrichta 98.06 3.00e-88 316.00
IUUC-Tni-120329 Tetraodon nigroviridis 76.13 1.00e-65 241.00
IUUC-Ttr-128649 Tursiops truncatus 98.06 1.00e-87 315.00
Created Date 25-Jun-2017

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