iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000030254.16	ENSMUST00000077088.10	ENSMUSP00000076341.4
ENSMUSG00000030254.16	ENSMUST00000113182.7	ENSMUSP00000108807.1
ENSMUSG00000030254.16	ENSMUST00000113180.7	ENSMUSP00000108805.1
ENSMUSG00000030254.16	ENSMUST00000068487.11	ENSMUSP00000070619.5
ENSMUSG00000030254.16	ENSMUST00000142079.1	ENSMUSP00000117582.1
ENSMUSG00000030254.16	ENSMUST00000156063.1	ENSMUSP00000138558.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	miRTarBase	microRNA
TRANSFAC	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/UBZ	UBZ	17720710

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.015	16.9	25	63
UBD/ZnF/UBZ	1.40e-07	32.7	201	224

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC+e f   +++ +C H ++  C+ k+       s + +CP+C
   Q: 25   CGICFEYFNIAVIIPQCSHNYCSLCIRKF------LSYKTQCPTC 63
           9*******88677666**********999......777888**** PP

UBD/ZnF/UBZ

   S: 1    llvCPvCqkmvdqtdfeeHlDeCl 24
           +++CPvC+  ++++++++HlD+Cl
   Q: 201  KVSCPVCGVSIPENHINKHLDSCL 224
           69*********************8 PP

Organism

Mus musculus

Functional Description
(View)

Homodimer. Interacts with UBE2A and UBE2B, one homodimer binding one molecule of UBE2B. Interacts with HLTF. Interacts with SHPRH. Interacts with SPRTN; leading to enhance chromatin association of RAD18 and RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. Interacts (via C-terminus and phosphorylated form) with SLF1 (via BRCT domains); this interaction is required for efficient repair of UV-induced DNA damage. Interacts with SLF2. Interacts with SMC5; this interaction is increased in a SLF1 or SLF2-dependent manner.

Protein Sequence
(Fasta)

MEVLAEPRWP PGLAVMKTID DLLRCGICFE YFNIAVIIPQ CSHNYCSLCI RKFLSYKTQC 60
PTCCVAVTEP DLRNNRLLDE LVKSMNFART HLLQFALESP PISPVSSTSK KVVVKVHNAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCACGTAGC TGACGTACGG TGTAGCGCGG GGAATTTCGA GTAGAGGAGC TGCGTGGCGG 60
GCCGGTAGCT GGCGGTCTCA TCAGGTGCGG CCATGGAGGT CCTGGCCGAG CCGCGATGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02037--SAP

SMART

SM00184--RING
SM00513--SAP
SM00734--ZnF_Rad18

Gene Ontology

GO:0005813--C:centrosome
GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0042405--C:nuclear inclusion body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0005657--C:replication fork
GO:0035861--C:site of double-strand break
GO:0001741--C:XY body
GO:0042802--F:identical protein binding
GO:0031593--F:polyubiquitin binding
GO:0032403--F:protein complex binding
GO:0043142--F:single-stranded DNA-dependent ATPase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000403--F:Y-form DNA binding
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0060548--P:negative regulation of cell death
GO:0045910--P:negative regulation of DNA recombination
GO:0051984--P:positive regulation of chromosome segregation
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0009411--P:response to UV
GO:0007283--P:spermatogenesis

KEGG

mmu:58186

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002086	Ailuropoda melanoleuca	61.69	0.00e+00	637.00
IUUC-Apl-003657	Anas platyrhynchos	54.47	6.00e-105	374.00
IUUC-Aca-005369	Anolis carolinensis	71.13	4.00e-59	219.00
IUUC-Ago-007876	Ashbya gossypii	23.96	3.00e-12	66.20
IUUC-Acl-008246	Aspergillus clavatus	26.89	3.00e-29	122.00
IUUC-Afl-008666	Aspergillus flavus	25.49	9.00e-29	121.00
IUUC-Afu-009052	Aspergillus fumigatus	26.17	2.00e-27	117.00
IUUC-Ani-009488	Aspergillus nidulans	27.62	1.00e-32	134.00
IUUC-Ang-009681	Aspergillus niger	24.05	3.00e-27	116.00
IUUC-Aor-010037	Aspergillus oryzae	24.01	2.00e-27	116.00
IUUC-Ate-010516	Aspergillus terreus	39.29	2.00e-13	68.90
IUUC-Ame-010630	Astyanax mexicanus	43.67	4.00e-76	278.00
IUUC-Bgr-012178	Blumeria graminis	29.44	1.00e-15	77.40
IUUC-Bta-012976	Bos taurus	77.39	3.00e-132	465.00
IUUC-Bci-013680	Botrytis cinerea	26.10	4.00e-29	122.00
IUUC-Cja-019453	Callithrix jacchus	63.27	2.00e-174	605.00
IUUC-Cfa-020856	Canis familiaris	63.57	6.00e-169	587.00
IUUC-Cpo-021950	Cavia porcellus	62.62	5.00e-173	600.00
IUUC-Csa-023997	Chlorocebus sabaeus	64.19	2.00e-171	595.00
IUUC-Cho-024771	Choloepus hoffmanni	73.68	7.00e-83	301.00
IUUC-Cgl-026668	Colletotrichum gloeosporioides	26.86	2.00e-16	80.50
IUUC-Cme-027202	Cyanidioschyzon merolae	36.47	3.00e-13	69.70
IUUC-Dre-028479	Danio rerio	45.55	5.00e-74	271.00
IUUC-Dno-028943	Dasypus novemcinctus	64.37	2.00e-168	585.00
IUUC-Dor-031046	Dipodomys ordii	72.01	1.00e-112	399.00
IUUC-Dse-031235	Dothistroma septosporum	27.51	7.00e-14	72.00
IUUC-Ete-032503	Echinops telfairi	52.47	3.00e-109	388.00
IUUC-Eca-033725	Equus caballus	67.35	2.00e-178	619.00
IUUC-Eeu-034573	Erinaceus europaeus	68.63	3.00e-113	402.00
IUUC-Fca-036495	Felis catus	68.39	3.00e-175	607.00
IUUC-Fal-036791	Ficedula albicollis	53.85	2.00e-93	335.00
IUUC-Fox-037868	Fusarium oxysporum	31.82	2.00e-12	67.00
IUUC-Fso-038144	Fusarium solani	28.49	2.00e-16	79.70
IUUC-Gmo-039152	Gadus morhua	43.02	5.00e-65	241.00
IUUC-Ggr-039737	Gaeumannomyces graminis	26.77	2.00e-15	77.00
IUUC-Gga-040788	Gallus gallus	54.84	2.00e-108	385.00
IUUC-Gac-041993	Gasterosteus aculeatus	44.00	2.00e-78	286.00
IUUC-Ggo-044889	Gorilla gorilla	64.25	5.00e-170	590.00
IUUC-Hsa-045957	Homo sapiens	64.04	7.00e-171	593.00
IUUC-Itr-048998	Ictidomys tridecemlineatus	64.43	0.00e+00	628.00
IUUC-Kpa-049300	Komagataella pastoris	35.87	9.00e-09	54.30
IUUC-Lch-050172	Latimeria chalumnae	52.48	3.00e-66	245.00
IUUC-Loc-052609	Lepisosteus oculatus	49.16	2.00e-81	296.00
IUUC-Lma-053037	Leptosphaeria maculans	24.26	6.00e-19	89.00
IUUC-Laf-053889	Loxodonta africana	65.64	3.00e-143	501.00
IUUC-Mcc-055853	Macaca mulatta	64.04	2.00e-168	585.00
IUUC-Meu-056866	Macropus eugenii	51.59	3.00e-81	295.00
IUUC-Mor-057071	Magnaporthe oryzae	26.50	3.00e-31	129.00
IUUC-Mpo-057628	Magnaporthe poae	25.49	2.00e-14	73.60
IUUC-Mla-058953	Melampsora laricipopulina	23.94	4.00e-22	99.80
IUUC-Mga-059687	Meleagris gallopavo	53.83	9.00e-103	367.00
IUUC-Mvi-060412	Microbotryum violaceum	20.56	4.00e-12	66.20
IUUC-Mmr-061563	Microcebus murinus	66.36	3.00e-179	621.00
IUUC-Mdo-062655	Monodelphis domestica	65.23	5.00e-123	434.00
IUUC-Mpu-065778	Mustela putorius furo	65.49	0.00e+00	634.00
IUUC-Mlu-068205	Myotis lucifugus	62.59	2.00e-160	559.00
IUUC-Nfi-068501	Neosartorya fischeri	27.54	2.00e-26	113.00
IUUC-Ncr-068917	Neurospora crassa	25.51	6.00e-17	82.00
IUUC-Nle-068990	Nomascus leucogenys	64.79	5.00e-172	597.00
IUUC-Opr-071146	Ochotona princeps	59.88	9.00e-144	503.00
IUUC-Ont-071835	Oreochromis niloticus	42.72	8.00e-74	270.00
IUUC-Oan-072827	Ornithorhynchus anatinus	41.35	4.00e-42	164.00
IUUC-Ocu-073986	Oryctolagus cuniculus	61.75	1.00e-161	563.00
IUUC-Ola-086997	Oryzias latipes	39.60	8.00e-61	227.00
IUUC-Olu-087771	Ostreococcus lucimarinus	32.00	1.00e-10	60.80
IUUC-Oga-088092	Otolemur garnettii	64.68	0.00e+00	645.00
IUUC-Oar-089651	Ovis aries	63.03	3.00e-155	541.00
IUUC-Ptr-091103	Pan troglodytes	64.61	6.00e-172	597.00
IUUC-Pan-092478	Papio anubis	63.45	2.00e-169	588.00
IUUC-Psi-093356	Pelodiscus sinensis	59.19	2.00e-118	419.00
IUUC-Pfo-096663	Poecilia formosa	41.34	3.00e-63	236.00
IUUC-Pab-098515	Pongo abelii	64.61	7.00e-173	600.00
IUUC-Pca-100588	Procavia capensis	53.42	6.00e-116	410.00
IUUC-Pva-102377	Pteropus vampyrus	64.04	2.00e-173	602.00
IUUC-Pgr-103556	Puccinia graminis	26.26	8.00e-10	58.90
IUUC-Pte-104362	Pyrenophora teres	32.14	8.00e-10	58.50
IUUC-Pyt-104823	Pyrenophora triticirepentis	25.82	9.00e-10	58.20
IUUC-Rno-105866	Rattus norvegicus	80.57	0.00e+00	748.00
IUUC-Sce-106454	Saccharomyces cerevisiae	40.00	5.00e-12	65.90
IUUC-Sha-107515	Sarcophilus harrisii	56.60	7.00e-124	437.00
IUUC-Sja-107689	Schizosaccharomyces japonicus	40.00	1.00e-11	64.70
IUUC-Spo-108248	Schizosaccharomyces pombe	42.50	3.00e-14	72.80
IUUC-Ssl-108430	Sclerotinia sclerotiorum	25.07	5.00e-26	112.00
IUUC-Sre-115123	Sporisorium reilianum	23.01	2.00e-13	70.10
IUUC-Ssc-115992	Sus scrofa	65.98	1.00e-133	469.00
IUUC-Tgu-117286	Taeniopygia guttata	52.62	8.00e-100	357.00
IUUC-Tru-117959	Takifugu rubripes	42.93	4.00e-66	244.00
IUUC-Tsy-119286	Tarsius syrichta	47.75	1.00e-114	406.00
IUUC-Tni-120570	Tetraodon nigroviridis	45.68	3.00e-71	261.00
IUUC-Tre-121893	Trichoderma reesei	24.16	3.00e-13	69.70
IUUC-Tvi-122405	Trichoderma virens	24.79	2.00e-25	110.00
IUUC-Tbe-127758	Tupaia belangeri	69.91	2.00e-72	266.00
IUUC-Ttr-128841	Tursiops truncatus	65.54	2.00e-172	598.00
IUUC-Vda-130021	Verticillium dahliae	30.77	2.00e-15	76.30
IUUC-Vpa-130169	Vicugna pacos	63.73	2.00e-131	462.00
IUUC-Xtr-132308	Xenopus tropicalis	53.48	9.00e-108	383.00
IUUC-Xma-133868	Xiphophorus maculatus	40.99	5.00e-66	244.00
IUUC-Yli-134474	Yarrowia lipolytica	31.52	1.00e-14	73.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence