iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ang-009703

Ensembl Protein ID

CAK43937

UniProt Accession

A2Q9N1; CREB_ASPNC

Genbank Protein ID

CAK43937.1

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase creB; Carbon catabolite repression protein B; Deubiquitinating enzyme creB; Ubiquitin thioesterase creB; Ubiquitin-hydrolyzing enzyme creB; Ubiquitin-specific-processing protease creB

Genbank Nucleotide ID

AM269976

Gene Name

creB; An01g08470

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
An01g08470	CAK43937	CAK43937

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.70e-82	275.4	90	483

Active Site

Position(s)	Description	Evidence
66	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
419	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 18   cLsnipelrellle........kkkeklneenp.................................................................... 42
           cL+   ++re++l+        +                                                                              
   Q: 90   CLYYSVPFREAVLNyptrtpieS---------Leaalaknlryqnfaanqeaeaqaekqrlanaqrpgappaqppkpedkdsseykkkialqslplletkn 181
           89999999999999555444440.........344455555566666666677888888999999999999999999999999999999999999999988 PP
   S: 43   ....kepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk...eknkpkeeeeeedkselsdeaeekk 134
                +++++l +sl+++fe+++  +s+ + v p+++l++l++e+e+f++ ++qDa+Efl+ +l+++  +++    ++  p     ++++s+++++++ +k
   Q: 182  nagsYGMSESLFTSLKDIFESVVasQSRIGIVRPQHFLDVLRRENEMFRSAMHQDAHEFLNLVLNEVVANVEAeamKQPIPSLPPADTTDSSRQSISSGSK 282
           888889999*************98899999****************************************97765555555556666777788888999** PP
   S: 135  kkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLk 235
           +  ++ ++++lF+g+l+s+++cl+c+nvs+r+e fldls+++++++     s+++cL++f++ee+l+++nk++c++c ++qeaek++k+k+lP++L lhLk
   Q: 283  TPNTTRWVHELFEGTLTSETQCLTCENVSQRDEIFLDLSVDLEQHS-----SVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLK 378
           **********************************************.....9************************************************* PP
   S: 236  RfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.....sta 330
           Rf+++e+ ++ +k++ +v +p +L l  f+t+++ ++  ++ YeL+avvvH G ++ +GHYv+++k ++++WllfdD+ V++v+++ v ++ g     + a
   Q: 379  RFKYTEDLQRLQKLFHRVVYPYHLRL--FNTTDDAED-PDRLYELYAVVVHIGgGPYHGHYVSIIKTQDRGWLLFDDEMVEPVDKNYVRNFFGdkpglACA 476
           *********************88887..566645544.49**************************************************999******** PP
   S: 331  YvlfYkr 337
           YvlfY++
   Q: 477  YVLFYQE 483
           *****97 PP

Organism

Aspergillus niger

Functional Description
(View)

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).

Protein Sequence
(Fasta)

MGSFLRSFRR DVGSSTPSVG ATPAKKEPLA LPITPLEKML QEMGSDSVRQ DGSDKFFGME 60
NVSWPILQPI PRFIGIANSG FSYSVRKYLC LYYSVPFREA VLNYPTRTPI ESLEAALAKN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTCTT TTCTGAGGAG TTTCCGAAGA GATGTGGTAA GTCCTTCGAT TTGCTGGCTT 60
GGCCGCGCTT CTTTTGCCTT GAAGTATGCT GTGGCCTTCA ACGTCCTTGG GGCATATAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0045013--P:carbon catabolite repression of transcription
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ang:ANI_1_1130014

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000193	Aegilops tauschii	46.15	2.00e-81	294.00
IUUC-Aml-001964	Ailuropoda melanoleuca	49.49	9.00e-85	305.00
IUUC-Atr-002650	Amborella trichopoda	47.94	3.00e-81	293.00
IUUC-Apl-003411	Anas platyrhynchos	49.16	2.00e-84	303.00
IUUC-Aca-005212	Anolis carolinensis	49.83	1.00e-84	305.00
IUUC-Aly-005830	Arabidopsis lyrata	46.71	3.00e-76	276.00
IUUC-Ath-006663	Arabidopsis thaliana	47.51	3.00e-79	286.00
IUUC-Ago-007871	Ashbya gossypii	42.20	1.00e-65	243.00
IUUC-Acl-008239	Aspergillus clavatus	71.79	0.00e+00	838.00
IUUC-Afl-008602	Aspergillus flavus	74.90	0.00e+00	920.00
IUUC-Afu-008816	Aspergillus fumigatus	79.68	0.00e+00	809.00
IUUC-Ani-009137	Aspergillus nidulans	67.88	0.00e+00	823.00
IUUC-Aor-009901	Aspergillus oryzae	73.46	0.00e+00	840.00
IUUC-Ate-010431	Aspergillus terreus	71.84	0.00e+00	883.00
IUUC-Ame-011015	Astyanax mexicanus	50.17	2.00e-85	307.00
IUUC-Bgr-012071	Blumeria graminis	53.37	9.00e-148	515.00
IUUC-Bta-012981	Bos taurus	49.83	3.00e-85	306.00
IUUC-Bci-013837	Botrytis cinerea	52.21	5.00e-154	536.00
IUUC-Bdi-014008	Brachypodium distachyon	47.08	1.00e-80	291.00
IUUC-Bol-015138	Brassica oleracea	47.51	5.00e-77	279.00
IUUC-Bra-016956	Brassica rapa	48.03	2.00e-79	287.00
IUUC-Cel-018379	Caenorhabditis elegans	40.77	7.00e-73	265.00
IUUC-Cja-018831	Callithrix jacchus	50.17	3.00e-85	306.00
IUUC-Cfa-020534	Canis familiaris	49.16	3.00e-84	303.00
IUUC-Cpo-021703	Cavia porcellus	50.17	7.00e-85	305.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	45.21	2.00e-65	241.00
IUUC-Csa-023841	Chlorocebus sabaeus	47.14	2.00e-80	291.00
IUUC-Cho-024902	Choloepus hoffmanni	38.38	7.00e-56	209.00
IUUC-Cin-025659	Ciona intestinalis	39.22	3.00e-69	253.00
IUUC-Csv-025828	Ciona savignyi	55.33	1.00e-63	235.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	54.77	2.00e-155	540.00
IUUC-Cne-026900	Cryptococcus neoformans	40.51	1.00e-65	242.00
IUUC-Cme-027339	Cyanidioschyzon merolae	31.97	5.00e-34	137.00
IUUC-Dre-027845	Danio rerio	50.51	4.00e-86	309.00
IUUC-Dno-029460	Dasypus novemcinctus	49.16	4.00e-84	303.00
IUUC-Dor-030972	Dipodomys ordii	50.97	4.00e-74	269.00
IUUC-Dse-031470	Dothistroma septosporum	48.72	8.00e-157	545.00
IUUC-Dme-032038	Drosophila melanogaster	57.07	2.00e-68	250.00
IUUC-Ete-032659	Echinops telfairi	54.24	8.00e-55	205.00
IUUC-Eca-033439	Equus caballus	49.49	7.00e-85	305.00
IUUC-Eeu-034916	Erinaceus europaeus	47.43	9.00e-66	241.00
IUUC-Fca-035524	Felis catus	48.82	3.00e-84	303.00
IUUC-Fal-036833	Ficedula albicollis	49.16	2.00e-84	304.00
IUUC-Fox-037682	Fusarium oxysporum	57.08	6.00e-151	526.00
IUUC-Fso-038299	Fusarium solani	55.18	5.00e-150	523.00
IUUC-Gmo-038763	Gadus morhua	50.17	1.00e-84	305.00
IUUC-Ggr-039806	Gaeumannomyces graminis	57.06	8.00e-155	538.00
IUUC-Gga-041151	Gallus gallus	49.16	3.00e-84	303.00
IUUC-Gac-041967	Gasterosteus aculeatus	50.51	1.00e-84	304.00
IUUC-Gma-043101	Glycine max	47.74	8.00e-82	295.00
IUUC-Ggo-044659	Gorilla gorilla	47.14	2.00e-80	290.00
IUUC-Hsa-045700	Homo sapiens	50.17	3.00e-85	306.00
IUUC-Hvu-047692	Hordeum vulgare	46.93	5.00e-80	289.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	49.49	8.00e-85	305.00
IUUC-Kpa-049250	Komagataella pastoris	51.08	3.00e-95	340.00
IUUC-Lch-050435	Latimeria chalumnae	49.83	3.00e-83	300.00
IUUC-Lpe-051368	Leersia perrieri	45.54	4.00e-78	283.00
IUUC-Loc-051968	Lepisosteus oculatus	49.16	2.00e-84	304.00
IUUC-Lma-053300	Leptosphaeria maculans	54.18	8.00e-168	582.00
IUUC-Laf-053887	Loxodonta africana	49.49	8.00e-85	305.00
IUUC-Mcc-055701	Macaca mulatta	50.17	4.00e-85	306.00
IUUC-Mor-057072	Magnaporthe oryzae	58.17	4.00e-156	543.00
IUUC-Mpo-057424	Magnaporthe poae	57.11	2.00e-154	538.00
IUUC-Mtr-057715	Medicago truncatula	47.78	8.00e-81	291.00
IUUC-Mla-059142	Melampsora laricipopulina	55.63	2.00e-100	358.00
IUUC-Mga-059195	Meleagris gallopavo	49.16	4.00e-84	303.00
IUUC-Mvi-060357	Microbotryum violaceum	54.39	2.00e-84	305.00
IUUC-Mmr-060751	Microcebus murinus	49.49	8.00e-85	305.00
IUUC-Mdo-062735	Monodelphis domestica	49.49	8.00e-85	305.00
IUUC-Mmu-063263	Mus musculus	49.83	3.00e-84	303.00
IUUC-Mac-065323	Musa acuminata	48.04	3.00e-79	286.00
IUUC-Mpu-066038	Mustela putorius furo	47.14	8.00e-81	292.00
IUUC-Mlu-068128	Myotis lucifugus	49.49	7.00e-85	305.00
IUUC-Nfi-068611	Neosartorya fischeri	70.95	0.00e+00	816.00
IUUC-Ncr-068699	Neurospora crassa	55.45	3.00e-158	550.00
IUUC-Nle-069767	Nomascus leucogenys	50.17	3.00e-85	306.00
IUUC-Opr-070980	Ochotona princeps	47.14	2.00e-80	290.00
IUUC-Ont-072658	Oreochromis niloticus	50.51	1.00e-84	305.00
IUUC-Oan-073372	Ornithorhynchus anatinus	48.82	2.00e-83	300.00
IUUC-Ocu-074322	Oryctolagus cuniculus	49.83	1.00e-84	305.00
IUUC-Oba-075220	Oryza barthii	45.54	3.00e-78	283.00
IUUC-Obr-076208	Oryza brachyantha	46.91	9.00e-75	271.00
IUUC-Ogl-077216	Oryza glaberrima	45.54	3.00e-78	283.00
IUUC-Ogu-078836	Oryza glumaepatula	45.54	3.00e-78	283.00
IUUC-Oin-079522	Oryza indica	45.54	3.00e-78	283.00
IUUC-Olo-080882	Oryza longistaminata	45.54	3.00e-78	283.00
IUUC-Ome-081549	Oryza meridionalis	45.54	3.00e-78	283.00
IUUC-Oni-082982	Oryza nivara	45.54	3.00e-78	283.00
IUUC-Opu-083532	Oryza punctata	45.54	4.00e-78	283.00
IUUC-Oru-084568	Oryza rufipogon	45.54	3.00e-78	283.00
IUUC-Osa-085299	Oryza sativa	45.54	3.00e-78	283.00
IUUC-Ola-087418	Oryzias latipes	50.51	9.00e-85	305.00
IUUC-Olu-087809	Ostreococcus lucimarinus	45.45	8.00e-65	238.00
IUUC-Oga-088298	Otolemur garnettii	49.49	1.00e-84	304.00
IUUC-Oar-090269	Ovis aries	49.83	9.00e-85	305.00
IUUC-Ptr-090467	Pan troglodytes	50.17	3.00e-85	306.00
IUUC-Pan-092437	Papio anubis	50.00	5.00e-84	302.00
IUUC-Psi-092993	Pelodiscus sinensis	48.82	1.00e-84	304.00
IUUC-Pma-094388	Petromyzon marinus	47.83	2.00e-81	294.00
IUUC-Pno-095044	Phaeosphaeria nodorum	56.97	2.00e-165	574.00
IUUC-Ppa-095275	Physcomitrella patens	49.50	7.00e-84	301.00
IUUC-Pfo-097052	Poecilia formosa	50.51	1.00e-84	305.00
IUUC-Pab-097797	Pongo abelii	50.17	3.00e-85	306.00
IUUC-Pop-099016	Populus trichocarpa	48.25	1.00e-82	298.00
IUUC-Pca-100835	Procavia capensis	51.05	2.00e-69	253.00
IUUC-Ppe-101474	Prunus persica	48.10	1.00e-81	295.00
IUUC-Pva-102878	Pteropus vampyrus	48.81	3.00e-83	300.00
IUUC-Pgr-103306	Puccinia graminis	54.75	8.00e-103	367.00
IUUC-Pte-104356	Pyrenophora teres	53.48	3.00e-167	580.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	52.51	3.00e-151	527.00
IUUC-Rno-106060	Rattus norvegicus	50.17	1.00e-84	304.00
IUUC-Sce-106367	Saccharomyces cerevisiae	41.59	4.00e-72	264.00
IUUC-Sha-107087	Sarcophilus harrisii	49.49	8.00e-85	305.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	55.22	2.00e-89	321.00
IUUC-Spo-108095	Schizosaccharomyces pombe	45.15	3.00e-101	360.00
IUUC-Smo-108674	Selaginella moellendorffii	49.66	4.00e-84	303.00
IUUC-Sit-110819	Setaria italica	46.50	1.00e-80	291.00
IUUC-Sly-111210	Solanum lycopersicum	48.06	8.00e-81	291.00
IUUC-Stu-112398	Solanum tuberosum	48.16	6.00e-80	288.00
IUUC-Sar-113216	Sorex araneus	48.48	3.00e-82	296.00
IUUC-Sbi-114724	Sorghum bicolor	47.40	2.00e-82	297.00
IUUC-Sre-115197	Sporisorium reilianum	57.14	9.00e-94	336.00
IUUC-Ssc-116321	Sus scrofa	49.49	2.00e-85	307.00
IUUC-Tgu-117482	Taeniopygia guttata	50.17	4.00e-83	299.00
IUUC-Tru-118613	Takifugu rubripes	50.51	9.00e-85	305.00
IUUC-Tsy-119520	Tarsius syrichta	53.23	6.00e-59	218.00
IUUC-Tni-120293	Tetraodon nigroviridis	50.51	9.00e-85	305.00
IUUC-Tca-121329	Theobroma cacao	49.50	1.00e-81	294.00
IUUC-Tre-122226	Trichoderma reesei	50.65	2.00e-155	540.00
IUUC-Tvi-122330	Trichoderma virens	56.69	2.00e-156	544.00
IUUC-Tae-124807	Triticum aestivum	47.25	4.00e-82	296.00
IUUC-Tur-126563	Triticum urartu	47.25	2.00e-82	297.00
IUUC-Tme-126890	Tuber melanosporum	67.26	1.00e-136	478.00
IUUC-Tbe-127783	Tupaia belangeri	49.49	7.00e-85	305.00
IUUC-Ttr-129083	Tursiops truncatus	49.83	3.00e-85	306.00
IUUC-Uma-129409	Ustilago maydis	56.14	3.00e-94	338.00
IUUC-Vda-129736	Verticillium dahliae	50.84	2.00e-138	484.00
IUUC-Vpa-130391	Vicugna pacos	47.14	1.00e-75	274.00
IUUC-Vvi-131371	Vitis vinifera	48.54	4.00e-83	299.00
IUUC-Xtr-132082	Xenopus tropicalis	48.48	1.00e-81	295.00
IUUC-Xma-133475	Xiphophorus maculatus	50.51	1.00e-84	305.00
IUUC-Yli-134632	Yarrowia lipolytica	59.94	9.00e-125	439.00
IUUC-Zma-134951	Zea mays	46.75	6.00e-81	292.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence