iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055898

UUCD1 version

UUC-MaM-00077

Ensembl Protein ID

ENSMMUP00000049515.1

UniProt Accession

F7H3H2; F7H3H2_MACMU

Genbank Protein ID

AFJ71419.1; EHH17982.1

Protein Name

E3 ubiquitin-protein ligase RNF144B

Genbank Nucleotide ID

JSUE03030356; CM001256

Gene Name

RNF144B; EGK_14508

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000045541.1	ENSMMUT00000074274.1	ENSMMUP00000049515.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	2.40e-51	175.1	30	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpek..leeseikellveeelykryekllleevveadaal 88
           Ck+Cl+e+sv+++t+l+eC+++fC++Clkqy++l+i+eg+ + i+cp++ c ++  l+e+ei++ lv  ++++ y++l++e++v+ d+ +
   Q: 30   CKLCLCEQSVDKMTTLQECRCIFCTACLKQYMQLAIREGCGSPITCPDMVCLNHgtLQEAEIAC-LVPVDQFQLYQRLKFEREVHLDPYR 118
           ***************************************************9988899******.6999********************* PP
   S: 89   kwcpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyiekneg 176
           +wcp +dC++v+ +++++  + + vec++c+ +fC++Ck++wH+++sC++ +  +  te   ++a   + +ea +k+Cp C+vyie+neg
   Q: 119  TWCPVADCQTVCPVASSDpgQPVLVECPSCHLKFCSCCKDAWHAEVSCRDNQPVVLPTE---HRALFGTDAEAPIKQCPVCRVYIERNEG 205
           *************9998877899999****************************99999...99************************** PP
   S: 177  CnhmtCakCkaefCwlC 193
           C++m+C++Ck++fCw+C
   Q: 206  CAQMMCKNCKHTFCWYC 222
           ***************** PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MGSAGRLHYL AMTAENPAPG DLAPAPLITC KLCLCEQSVD KMTTLQECRC IFCTACLKQY 60
MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF QLYQRLKFER EVHLDPYRTW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTCGGAGG AGGGGTCCGA GACGCGCCAA AGGGTTGGTA GTTAGGCGAC CTGAATGCCT 60
TTGATACCTG AAGCCGCAAC CTGCAGAAGC TGATAGCGGA CCCCGAGCGT GCGCGCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0031966--C:mitochondrial membrane
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mcc:705099

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001257	Ailuropoda melanoleuca	93.40	2.00e-170	591.00
IUUC-Apl-004112	Anas platyrhynchos	81.85	2.00e-130	458.00
IUUC-Aca-004533	Anolis carolinensis	75.91	1.00e-136	479.00
IUUC-Bta-012641	Bos taurus	93.75	1.00e-168	585.00
IUUC-Cja-019626	Callithrix jacchus	81.52	7.00e-144	503.00
IUUC-Cfa-020702	Canis familiaris	94.72	2.00e-172	597.00
IUUC-Cpo-022147	Cavia porcellus	94.39	3.00e-169	587.00
IUUC-Csa-023473	Chlorocebus sabaeus	100.00	3.00e-180	623.00
IUUC-Cho-024298	Choloepus hoffmanni	90.66	2.00e-140	491.00
IUUC-Dre-028099	Danio rerio	65.41	2.00e-91	328.00
IUUC-Dno-029122	Dasypus novemcinctus	87.50	1.00e-156	545.00
IUUC-Dor-030669	Dipodomys ordii	95.71	6.00e-133	466.00
IUUC-Ete-033141	Echinops telfairi	80.20	3.00e-131	461.00
IUUC-Eca-034360	Equus caballus	95.71	1.00e-173	602.00
IUUC-Eeu-034538	Erinaceus europaeus	73.24	5.00e-85	306.00
IUUC-Fca-036055	Felis catus	92.74	3.00e-168	583.00
IUUC-Fal-037339	Ficedula albicollis	79.93	7.00e-132	462.00
IUUC-Gmo-038780	Gadus morhua	60.81	4.00e-86	310.00
IUUC-Gga-040256	Gallus gallus	80.07	6.00e-133	466.00
IUUC-Gac-042127	Gasterosteus aculeatus	62.24	5.00e-94	337.00
IUUC-Ggo-044867	Gorilla gorilla	98.02	9.00e-178	615.00
IUUC-Hsa-046928	Homo sapiens	98.35	3.00e-178	617.00
IUUC-Hvu-047484	Hordeum vulgare	30.14	2.00e-17	83.60
IUUC-Itr-048250	Ictidomys tridecemlineatus	96.37	2.00e-109	387.00
IUUC-Lch-050168	Latimeria chalumnae	73.11	1.00e-131	462.00
IUUC-Lpe-051649	Leersia perrieri	29.56	1.00e-16	82.00
IUUC-Loc-052150	Lepisosteus oculatus	60.57	1.00e-86	313.00
IUUC-Laf-053967	Loxodonta africana	94.39	4.00e-170	590.00
IUUC-Meu-056628	Macropus eugenii	97.44	3.00e-43	168.00
IUUC-Mtr-057989	Medicago truncatula	25.82	4.00e-18	85.10
IUUC-Mga-059820	Meleagris gallopavo	79.00	5.00e-131	460.00
IUUC-Mmr-060680	Microcebus murinus	94.06	4.00e-170	590.00
IUUC-Mdo-062839	Monodelphis domestica	86.18	2.00e-154	537.00
IUUC-Mmu-063339	Mus musculus	86.80	2.00e-147	514.00
IUUC-Mac-065414	Musa acuminata	27.96	3.00e-19	89.00
IUUC-Mpu-065973	Mustela putorius furo	93.40	3.00e-171	593.00
IUUC-Mlu-067112	Myotis lucifugus	93.73	7.00e-162	562.00
IUUC-Nle-069795	Nomascus leucogenys	98.02	2.00e-178	618.00
IUUC-Opr-070390	Ochotona princeps	89.44	4.00e-155	540.00
IUUC-Ont-072329	Oreochromis niloticus	60.92	1.00e-90	325.00
IUUC-Oan-072980	Ornithorhynchus anatinus	78.57	4.00e-137	480.00
IUUC-Ocu-073845	Oryctolagus cuniculus	93.73	1.00e-169	588.00
IUUC-Ola-086872	Oryzias latipes	61.80	5.00e-86	310.00
IUUC-Oga-088954	Otolemur garnettii	95.05	3.00e-172	597.00
IUUC-Oar-089879	Ovis aries	94.41	1.00e-169	588.00
IUUC-Ptr-090685	Pan troglodytes	98.35	3.00e-178	617.00
IUUC-Pan-092086	Papio anubis	99.67	5.00e-180	623.00
IUUC-Psi-093481	Pelodiscus sinensis	81.19	4.00e-138	484.00
IUUC-Pfo-096065	Poecilia formosa	64.77	5.00e-92	330.00
IUUC-Pab-098031	Pongo abelii	98.02	2.00e-177	613.00
IUUC-Pca-100936	Procavia capensis	92.08	1.00e-165	575.00
IUUC-Pva-102864	Pteropus vampyrus	84.16	7.00e-148	516.00
IUUC-Rno-105503	Rattus norvegicus	86.80	3.00e-147	514.00
IUUC-Sha-107425	Sarcophilus harrisii	86.18	1.00e-154	538.00
IUUC-Stu-112736	Solanum tuberosum	28.30	4.00e-19	88.60
IUUC-Ssc-115458	Sus scrofa	93.49	1.00e-158	551.00
IUUC-Tgu-117226	Taeniopygia guttata	78.85	1.00e-131	461.00
IUUC-Tru-118362	Takifugu rubripes	65.04	7.00e-95	340.00
IUUC-Tsy-119255	Tarsius syrichta	96.04	2.00e-173	601.00
IUUC-Tni-120140	Tetraodon nigroviridis	61.73	2.00e-88	318.00
IUUC-Tae-124420	Triticum aestivum	31.82	3.00e-18	86.70
IUUC-Tbe-127306	Tupaia belangeri	93.73	9.00e-170	588.00
IUUC-Ttr-128923	Tursiops truncatus	94.41	5.00e-158	550.00
IUUC-Vpa-130148	Vicugna pacos	94.72	1.00e-170	591.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence