iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Position(s)	Description	Evidence
125	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
128	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
302		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 118  YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekqtsvadLLASFNDQSTSD 206
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 207  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHIFPEGS-E 291
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 292  PKVYLLYRPGHYDILYK 308
           ***************96 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MCGVEGCCQG GATRRGSLPG GRQLATRKRS VVRRCLKMAA EEPQQQKQEP LGSDSEGVNC 60
LAYDEAIMAQ QDRIQQEIAV QNPLVSERLE LSVLYKEYAE DDNIYQQKIK DLHKKYSYIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGTGGGG TGGAGGTGCG GATCTGGGGC GCCCGGCCTC TCCTACAGGT CTCAGGTCCG 60
CAGGCCTGGC GTGCCAGCAC CTGCCACGGG ACTGGAAGCC CATTCCTTGA CAACGCCTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	97.67	1.00e-171	594.00
IUUC-Apl-003233	Anas platyrhynchos	58.46	1.00e-18	84.00
IUUC-Aca-004648	Anolis carolinensis	85.40	5.00e-137	479.00
IUUC-Aly-005710	Arabidopsis lyrata	42.12	6.00e-52	197.00
IUUC-Ath-007112	Arabidopsis thaliana	43.24	7.00e-51	194.00
IUUC-Afl-008439	Aspergillus flavus	34.18	3.00e-08	52.00
IUUC-Ame-010662	Astyanax mexicanus	82.89	1.00e-129	455.00
IUUC-Bta-013533	Bos taurus	98.89	1.00e-152	531.00
IUUC-Bol-016100	Brassica oleracea	42.05	2.00e-50	192.00
IUUC-Bra-017705	Brassica rapa	39.15	3.00e-45	175.00
IUUC-Cel-018295	Caenorhabditis elegans	34.42	1.00e-41	162.00
IUUC-Cja-019190	Callithrix jacchus	98.05	1.00e-173	601.00
IUUC-Cfa-020430	Canis familiaris	100.00	1.00e-149	521.00
IUUC-Cpo-022355	Cavia porcellus	99.63	6.00e-154	536.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	38.80	2.00e-46	179.00
IUUC-Csa-023286	Chlorocebus sabaeus	96.79	2.00e-151	528.00
IUUC-Cin-025507	Ciona intestinalis	43.33	3.00e-44	171.00
IUUC-Csv-026273	Ciona savignyi	49.80	8.00e-69	253.00
IUUC-Dre-027843	Danio rerio	79.32	3.00e-126	444.00
IUUC-Dno-029165	Dasypus novemcinctus	99.00	1.00e-117	414.00
IUUC-Dor-030943	Dipodomys ordii	99.63	6.00e-154	536.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	2.00e-78	285.00
IUUC-Ete-032296	Echinops telfairi	96.23	2.00e-89	322.00
IUUC-Eca-033695	Equus caballus	98.81	4.00e-148	516.00
IUUC-Fca-036441	Felis catus	100.00	2.00e-149	521.00
IUUC-Gmo-038908	Gadus morhua	78.83	1.00e-126	445.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.41	6.00e-33	135.00
IUUC-Gga-040460	Gallus gallus	81.55	4.00e-133	466.00
IUUC-Gac-042417	Gasterosteus aculeatus	81.20	2.00e-122	431.00
IUUC-Gma-043712	Glycine max	41.13	1.00e-51	196.00
IUUC-Ggo-044552	Gorilla gorilla	100.00	2.00e-92	331.00
IUUC-Hsa-046766	Homo sapiens	100.00	5.00e-154	536.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	99.63	6.00e-154	536.00
IUUC-Lch-050602	Latimeria chalumnae	81.35	5.00e-119	420.00
IUUC-Laf-053705	Loxodonta africana	99.63	6.00e-154	536.00
IUUC-Mcc-055745	Macaca mulatta	93.77	2.00e-150	524.00
IUUC-Meu-056569	Macropus eugenii	85.61	5.00e-135	473.00
IUUC-Mtr-057712	Medicago truncatula	43.49	1.00e-46	179.00
IUUC-Mvi-060358	Microbotryum violaceum	33.94	3.00e-15	75.90
IUUC-Mmr-061123	Microcebus murinus	99.57	9.00e-128	449.00
IUUC-Mdo-062613	Monodelphis domestica	87.13	3.00e-124	437.00
IUUC-Mmu-063658	Mus musculus	99.63	6.00e-154	536.00
IUUC-Mac-065274	Musa acuminata	37.60	6.00e-39	154.00
IUUC-Mpu-066172	Mustela putorius furo	100.00	5.00e-154	536.00
IUUC-Mlu-066966	Myotis lucifugus	98.01	1.00e-169	588.00
IUUC-Nle-069519	Nomascus leucogenys	88.17	3.00e-93	334.00
IUUC-Ont-071901	Oreochromis niloticus	82.47	8.00e-125	439.00
IUUC-Ola-087331	Oryzias latipes	80.90	7.00e-86	309.00
IUUC-Oga-088064	Otolemur garnettii	100.00	5.00e-154	536.00
IUUC-Oar-089251	Ovis aries	98.42	2.00e-147	514.00
IUUC-Psi-093823	Pelodiscus sinensis	87.74	6.00e-134	469.00
IUUC-Pma-094366	Petromyzon marinus	72.01	2.00e-103	368.00
IUUC-Pfo-096734	Poecilia formosa	80.88	5.00e-114	403.00
IUUC-Pab-097919	Pongo abelii	100.00	9.00e-127	445.00
IUUC-Pop-099401	Populus trichocarpa	41.24	2.00e-48	185.00
IUUC-Ppe-101977	Prunus persica	42.38	1.00e-51	197.00
IUUC-Pva-102499	Pteropus vampyrus	100.00	3.00e-149	520.00
IUUC-Rno-105233	Rattus norvegicus	99.63	6.00e-154	536.00
IUUC-Sha-107081	Sarcophilus harrisii	93.31	4.00e-156	543.00
IUUC-Sly-111640	Solanum lycopersicum	42.01	3.00e-49	188.00
IUUC-Ssc-116202	Sus scrofa	100.00	5.00e-154	536.00
IUUC-Tru-117664	Takifugu rubripes	76.53	1.00e-122	432.00
IUUC-Tca-121467	Theobroma cacao	41.54	1.00e-50	192.00
IUUC-Tbe-128116	Tupaia belangeri	98.76	3.00e-93	334.00
IUUC-Ttr-128622	Tursiops truncatus	99.26	2.00e-151	527.00
IUUC-Vvi-131389	Vitis vinifera	43.75	7.00e-53	200.00
IUUC-Xma-134191	Xiphophorus maculatus	81.27	6.00e-115	406.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence